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学者姓名：田永奇
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Abstract ：
目的：研究石花菜的成分，为其功能食品的研发提供基础数据。方法：采用薄层色谱、液-质谱联用方法分析石花菜醇提物的化学成分的丰富度。通过硅胶柱、高效液相等色谱方法对其进行分离纯化，并用气-质谱联用、核磁结合文献确证化合物结构；并对部分化合物抗氧化活性进行测定。结果：薄层色谱、液-质谱联用分析表明石花菜醇提物中含有丰富的次级代谢产物，且很可能是甾醇类成分。采用气-质谱联用方法从中鉴定到29个化合物（5个为甾醇类化合物），其中棕榈酸（46.76%）、棕榈酸乙酯（13.82%）、胆甾醇（7.20%）、胆甾-4,6-二烯（4.99%）为含量最高的4个化合物。经色谱分离、核磁鉴定出9个单体化合物，分别为胆甾醇（1）、1,2-二醇植烯（2）、帕格甾醇C(3)、6-羟基-胆甾-4-烯-3-酮（4）、胆甾-5-烯-7-酮（5）、胆甾-5-烯-3β,7α二醇（6）、胆甾-5-烯-3β,7β二醇（7）、胆甾-4-烯-6-酮（8）、3-羟乙基-2-甲基-马来酰亚胺（9）。其中，化合物7清除DPPH自由基和ABTS自由基能力最好，其IC50值分别为180μg/mL和12.2μg/mL。结论：首次系统研究了石花菜醇提物的成分，化合物3、8、9为新天然产物。部分甾醇类化合物具有较好的抗氧化活性。
Keyword ：
成分 成分 抗氧化活性 抗氧化活性 甾体 甾体 石花菜醇提物 石花菜醇提物
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| GB/T 7714 | 田永奇 , 罗海涛 , 丁婷 et al. 石花菜醇提物成分分析 [J]. | 中国食品学报 , 2024 , 24 (02) : 269-280 . |
| MLA | 田永奇 et al. "石花菜醇提物成分分析" . | 中国食品学报 24 . 02 (2024) : 269-280 . |
| APA | 田永奇 , 罗海涛 , 丁婷 , 王奇升 , 邓尚贵 , 汪少芸 . 石花菜醇提物成分分析 . | 中国食品学报 , 2024 , 24 (02) , 269-280 . |
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The purpose of this study was to explore the potential of the development and application of Paecilomyces hepiali, a fungus with edible and medicinal value, as a foodborne antioxidant and anti-aging agent. Its n-butanol extract (PHE) from rice cultures was selected for anti-aging experiment because of significant free radical scavenging activity in vitro. In vivo, PHE could significantly prolong the mean lifespan, 50 % survival days, and the maximum lifespan of Drosophila on a high-fat diet. It is amazing that the mean lifespan increased from 19.1 days to 32.9 days, 50 % survival days increased from 15.7 days to 34.3 days, and the maximum lifespan extended from 44.7 days to 52.7 days, when the high-fat female Drosophila model was fed with 10 mu g/mL PHE. Further research showed that PHE reduced the accumulation of peroxide products and increased the activity of antioxidant enzymes. Then, through antioxidant activity tracking, dimerumic acid (compound 1, the IC50 value of 3.4 mu g/mL on DPPH free radicals scavenging activity), 4,5-dihydroxy-3-methoxypentanoic acid (compound 2, new compound), and thymidine (compound 3) were isolated from PHE. It is worth mentioning that dimerumic acid, the major antioxidant compound of PHE (content up to 3 %), was discovered in P. hepiali for the first time. It was concluded that PHE showed excellent anti-aging activity at a very low concentration on fat diet-induced high fat Drosophila melanogaster, and dimerumic acid may be its main material basis. These results indicated that PHE had the potential to be developed as antioxidant and anti-aging agent in the healthcare industry. (C) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
Keyword ：
Anti-aging Anti-aging Dimerumic acid Dimerumic acid Drosophila Drosophila Paecilomyces hepiali Paecilomyces hepiali
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| GB/T 7714 | Dan, Akang , Chen, Yushi , Tian, Yongqi et al. In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali [J]. | FOOD SCIENCE AND HUMAN WELLNESS , 2023 , 12 (4) : 1204-1211 . |
| MLA | Dan, Akang et al. "In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali" . | FOOD SCIENCE AND HUMAN WELLNESS 12 . 4 (2023) : 1204-1211 . |
| APA | Dan, Akang , Chen, Yushi , Tian, Yongqi , Wang, Shaoyun . In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali . | FOOD SCIENCE AND HUMAN WELLNESS , 2023 , 12 (4) , 1204-1211 . |
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On the basis of single factor experiment, the extraction process of Gelidium amansii ethanol extract (GAEE) was optimized by response surface methodology. Then, the GAEE was successively extracted by petroleum ether, ethyl acetate and n-butanol, and the antioxidant and antibacterial activities of different extraction phases were evaluated. The results showed that the optimum extraction conditions were as follows: extraction time was 64 min, ultrasonic power was 350 W, extraction temperature was 55 !, ethanol concentration was 60% and solid-liquid ratio was 1:35. The extraction rate of GAEE was 1.654 g/g, and DPPH radical scavenging rate of GAEE (2 mg/mL) was 58.29% Subsequent experiments proved that the antioxidant and antibacterial activities of different extraction phases were concentration dependent, and the antioxidant and antibacterial activities of ethyl acetate phase were the strongest. IC50 values of ethyl acetate phase against DPPH, ALTS free radicals, and hydroxyl radical were 672.4, 14.1, 599.7 μg/mL respectively. Their minimum in hibitory concentrations (DIC) of ethyl acetate phase against Staphylococcus aureus and Vibrio parahaemolyticus were 156.3, 156.3 μg/mL, and the minimum bactericidal concentrations (DLC) of ethyl acetate phase against Staphylococcus aureus and Vibrio parahaemolyticus were 625, 312.5 μg/mL. © 2023 Chinese Institute of Food Science and Technology. All rights reserved.
Keyword ：
Antioxidants Antioxidants Bacteria Bacteria Ethanol Ethanol Extraction Extraction Free radicals Free radicals
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| GB/T 7714 | Wang, Qisheng , Dan, Akang , Luo, Haitao et al. Studies on the Extraction Process, Antioxidant and Antibacterial Activity of Gelidium amansii Ethanol Extract [J]. | Journal of Chinese Institute of Food Science and Technology , 2023 , 23 (1) : 171-183 . |
| MLA | Wang, Qisheng et al. "Studies on the Extraction Process, Antioxidant and Antibacterial Activity of Gelidium amansii Ethanol Extract" . | Journal of Chinese Institute of Food Science and Technology 23 . 1 (2023) : 171-183 . |
| APA | Wang, Qisheng , Dan, Akang , Luo, Haitao , Tian, Yongqi , Wang, Shaoyun , Deng, Shanggui . Studies on the Extraction Process, Antioxidant and Antibacterial Activity of Gelidium amansii Ethanol Extract . | Journal of Chinese Institute of Food Science and Technology , 2023 , 23 (1) , 171-183 . |
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Abstract ：
The purpose of this study was to explore the potential of the development and application of Paecilomyces hepiali, a fungus with edible and medicinal value, as a foodborne antioxidant and anti-aging agent. Its n-butanol extract (PHE) from rice cultures was selected for anti-aging experiment because of significant free radical scavenging activity in vitro. In vivo, PHE could significantly prolong the mean lifespan, 50％ survival days, and the maximum lifespan of Drosophila on a high-fat diet. It is amazing that the mean lifespan increased from 19.1 days to 32.9 days, 50％ survival days increased from 15.7 days to 34.3 days, and the maximum lifespan extended from 44.7 days to 52.7 days, when the high-fat female Drosophila model was fed with 10 μg/mL PHE. Further research showed that PHE reduced the accumulation of peroxide products and increased the activity of antioxidant enzymes. Then, through antioxidant activity tracking, dimerumic acid (compound 1, the IC50 value of 3.4 μg/mL on DPPH free radicals scavenging activity), 4,5-dihydroxy-3-methoxypentanoic acid (compound 2, new compound), and thymidine (compound 3) were isolated from PHE. It is worth mentioning that dimerumic acid, the major antioxidant compound of PHE (content up to 3％), was discovered in P. hepiali for the first time. It was concluded that PHE showed excellent anti-aging activity at a very low concentration on fat diet-induced high fat Drosophila melanogaster, and dimerumic acid may be its main material basis. These results indicated that PHE had the potential to be developed as antioxidant and anti-aging agent in the healthcare industry.
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| GB/T 7714 | Akang Dan , Yushi Chen , Yongqi Tian et al. In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali [J]. | 食品科学与人类健康（英文） , 2023 , 12 (4) : 1204-1211 . |
| MLA | Akang Dan et al. "In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali" . | 食品科学与人类健康（英文） 12 . 4 (2023) : 1204-1211 . |
| APA | Akang Dan , Yushi Chen , Yongqi Tian , Shaoyun Wang . In vivo anti-aging properties on fat diet-induced high fat Drosophila melanogaster of n-butanol extract from Paecilomyces hepiali . | 食品科学与人类健康（英文） , 2023 , 12 (4) , 1204-1211 . |
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在单因素实验基础上,通过响应面法优化石花菜醇提物的提取工艺.将石花菜醇提物经石油醚、乙酸乙酯和正丁醇依次萃取,研究不同萃取相的抗氧化和抑菌活性.结果表明,石花菜醇提物的最佳提取工艺为:60％乙醇溶液、料液比1:35、提取时间64 min、超声功率350 W、提取温度55℃.在此条件下,石花菜醇提物得率为0.0165 g/g,DPPH自由基清除率为58.29％(质量浓度2 mg/mL).不同萃取相抗氧化和抗菌活性均具有浓度依赖性,其中乙酸乙酯相活性最强,清除DPPH自由基、ABTS+自由基和羟基自由基的IC50值分别为672.4,14.1,599.7μg/mL.对金黄色葡萄球菌和副溶血性弧菌的最小抑菌浓度(MIC)分别为156.3,156.3μg/mL,最小杀菌浓度(MBC)分别为625,312.5μg/mL.
Keyword ：
抗氧化 抗氧化 抗菌活性 抗菌活性 石花菜 石花菜 醇提物 醇提物
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| GB/T 7714 | 王奇升 , 但阿康 , 罗海涛 et al. 石花菜醇提物提取工艺及抗氧化、抗菌活性研究 [J]. | 中国食品学报 , 2023 , 23 (1) : 171-183 . |
| MLA | 王奇升 et al. "石花菜醇提物提取工艺及抗氧化、抗菌活性研究" . | 中国食品学报 23 . 1 (2023) : 171-183 . |
| APA | 王奇升 , 但阿康 , 罗海涛 , 田永奇 , 汪少芸 , 邓尚贵 . 石花菜醇提物提取工艺及抗氧化、抗菌活性研究 . | 中国食品学报 , 2023 , 23 (1) , 171-183 . |
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For food preservation, the packaging film needs to have higher antibacterial activity in initial phase and keep longer activity. In this study, cinnamaldehyde (CA) and its sulfobutyl ether-beta-cyclodextrin inclusion complex (CA/S) were used to fabricate fish gelatin antibacterial composite films. The addition enhanced the elongation at break and light barrier property of the films. Film forming solution incorporated with CA and CA/S presented the most excellent inhibition ratio against Pseudomonas aeruginosa, which was 98.43 +/- 1.11% in initial period and still 82.97 +/- 4.55% at 72 h. Further, the packaging solution of gelatin combined CA and CA/S effectively inhibited the growth of microorganisms during preservation of grass carp slices. Especially, the total volatile salt-based nitrogen (TVB-N) did not exceed 10 mg/100 g at the end of storage, indicating that the active coating could obviously extend the shelf life of fish muscle. This work provided a promising food packaging system with antimicrobial and environmentally friendly.
Keyword ：
Cinnamaldehyde Cinnamaldehyde Film and coating Film and coating Grass carp Grass carp Inclusion complex Inclusion complex Silver carp skin gelatin Silver carp skin gelatin
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| GB/T 7714 | Wu, Jiulin , Song, Gaojie , Huang, Ruyang et al. Fish gelatin films incorporated with cinnamaldehyde and its sulfobutyl ether-beta-cyclodextrin inclusion complex and their application in fish preservation [J]. | FOOD CHEMISTRY , 2023 , 418 . |
| MLA | Wu, Jiulin et al. "Fish gelatin films incorporated with cinnamaldehyde and its sulfobutyl ether-beta-cyclodextrin inclusion complex and their application in fish preservation" . | FOOD CHEMISTRY 418 (2023) . |
| APA | Wu, Jiulin , Song, Gaojie , Huang, Ruyang , Yan, Yongyong , Li, Qingxiang , Guo, Xiaoban et al. Fish gelatin films incorporated with cinnamaldehyde and its sulfobutyl ether-beta-cyclodextrin inclusion complex and their application in fish preservation . | FOOD CHEMISTRY , 2023 , 418 . |
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Obesity has become an increasingly serious public health problem. Pancreatic lipase (PL) is identified as a ideal target for the prevention and treatment of obesity. Orlistat, the only approved PL inhibitor (PLI), is a powerful weight loss drug but has many side effects. Therefore, there is an urgent need to discover powerful PLIs with high safety. Protein hydrolysate has been demonstrated to be a treasure trove of PLIs, but recognizing responsible functional peptides from them is like looking for a needle in a haystack. In this work, we synthesized and optimized a PL ligand fishing model (PLLFM) using magnetic nanoparticles (MNPs), then PLLFM was used to quickly fish out potential PLIs from the Cod meat hydrolysate (CMH). Finally, two new PLIs, GSPPPSG and KLEGDLK were identified with IC50 of 0.60 and 1.08 mg/mL, respectively. The Lineweaver-Burk diagram showed that GSPPPSG is a non-competitively dominant mixed-type PLI, whereas KLEGDLK is a competitive inhibitory-type PLI. Moreover, molecular docking suggested that both peptides can stably bind to the key amino acid residues of the PL active site, mainly through hydrogen bonding, hydrophobic, and electrostatic interactions. In general, we not only established a method to rapidly fish out potential PLIs from protein hydrolysate, but also provided safe and efficient lead compounds for the development of novel diet foods or drugs.
Keyword ：
inhibition mechanism inhibition mechanism ligand fishing ligand fishing molecular docking molecular docking pancreatic lipase inhibitor pancreatic lipase inhibitor protein hydrolysate protein hydrolysate
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| GB/T 7714 | Tian, Yongqi , Liu, Cuicui , Wang, Shaoyun et al. Efficient screening of pancreatic lipase inhibitors from cod meat hydrolysate through ligand fishing strategy [J]. | FRONTIERS IN NUTRITION , 2022 , 9 . |
| MLA | Tian, Yongqi et al. "Efficient screening of pancreatic lipase inhibitors from cod meat hydrolysate through ligand fishing strategy" . | FRONTIERS IN NUTRITION 9 (2022) . |
| APA | Tian, Yongqi , Liu, Cuicui , Wang, Shaoyun , Du, Ming , Zhu, Beiwei . Efficient screening of pancreatic lipase inhibitors from cod meat hydrolysate through ligand fishing strategy . | FRONTIERS IN NUTRITION , 2022 , 9 . |
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Gelidium amansii (GA) is a kind of red alga homologous to medicine and food and is distributed all over the world. Studies on GA are mainly focused on its polysaccharides, with little research on the ethanol extract. The ethanol extract of Gelidium amansii (GAE) was subjected to a reverse-phase column to obtain 7 components. Among them, 100% methanol solution (GAM), enriched with phytene-1,2-diol, exhibited the strongest DPPH free radical scavenging activity (IC50 = 0.17 mg mL(-1)). Subsequently, high-fat male flies (HMFs) were used as a model to explore the antioxidant and anti-aging effects of GAM in vivo. Studies showed that GAM can effectively prolong the lifespan of HMFs. When GAM concentrations were 0.2 and 1.0 mg mL(-1), the average lifespan of HMFs was increased by 28.7 and 40.7%, respectively, while the longest lifespan of HMFs was increased by 20.55% and 32.88%, respectively. Further research revealed that GAM can significantly downregulate the levels of malondialdehyde (MDA) and protein carbonyl (PCO), and can significantly upregulate the levels of catalase (CAT) and total superoxide dismutase (T-SOD). In addition, by analyzing differential metabolites, we found that GAM relieves aging caused by oxidative stress by regulating amino acid, lipid, sugar, and energy metabolism. The GAM group significantly regulated the levels of adenine, cholic acid, glutamate, l-proline, niacin, and stachyose which tend to recover to the levels of the normal diet male fly (NMF) group. In general, our research provides ideas for the high-value utilization of GA and provides a lead compound for the research and development of anti-aging food or medicine.
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| GB/T 7714 | Chen, Yushi , Wang, Qishen , Luo, Haitao et al. Mechanisms of the ethanol extract of Gelidium amansii for slow aging in high-fat male Drosophila by metabolomic analysis [J]. | FOOD & FUNCTION , 2022 , 13 (19) : 10110-10120 . |
| MLA | Chen, Yushi et al. "Mechanisms of the ethanol extract of Gelidium amansii for slow aging in high-fat male Drosophila by metabolomic analysis" . | FOOD & FUNCTION 13 . 19 (2022) : 10110-10120 . |
| APA | Chen, Yushi , Wang, Qishen , Luo, Haitao , Deng, Shanggui , Tian, Yongqi , Wang, Shaoyun . Mechanisms of the ethanol extract of Gelidium amansii for slow aging in high-fat male Drosophila by metabolomic analysis . | FOOD & FUNCTION , 2022 , 13 (19) , 10110-10120 . |
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To study the chemical constituents from the the deep-sea fungus Alternaria sp. F49. Seven compounds were isolated from the EtOAc extract by using silica gel, Sephadex LH-20, ODS and HPLC methods. Based on the spectroscopic analysis, their structures were identified as (8R)-5-O-methyl-orcinotriol (1), orcinotriol (2), α-acety-lorcinol (3), 3'-hydroxyalternariol 5-O-methyl ether (4), altenusiol (5), altenusin (6), and 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (7). (8R)-5-O-Methyl-orcinotriol (1) is a new phenolic compound which has never been reported in the literature. Compounds 4-7 showed strong DPPH free radical scavenging activity; whereas compounds 1-7 showed strong ABTS free radical scavenging activity. © 2022, Chinese Pharmaceutical Association. All rights reserved.
Keyword ：
ABTS free radical scavenging activity; Alternaria sp ABTS free radical scavenging activity; Alternaria sp F49; DPPH free radical scavenging activity; secondary metabolite; sponge-derived fungus F49; DPPH free radical scavenging activity; secondary metabolite; sponge-derived fungus
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| GB/T 7714 | Chen, Y.-S. , Leng, J.-R. , Lin, S.-T. et al. Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp. F49 [J]. | Yaoxue Xuebao , 2022 , 57 (7) : 2120-2125 . |
| MLA | Chen, Y.-S. et al. "Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp. F49" . | Yaoxue Xuebao 57 . 7 (2022) : 2120-2125 . |
| APA | Chen, Y.-S. , Leng, J.-R. , Lin, S.-T. , Wang, S.-Y. , Tian, Y.-Q. . Research on the antioxidant activity of metabolites from a sponge-derived fungus Alternaria sp. F49 . | Yaoxue Xuebao , 2022 , 57 (7) , 2120-2125 . |
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Insight is provided into the mechanism of peptide gelation, a self-assembled process of particular interest, due to its wide existence in natural events and broad applications in food and biomaterials field, but hard to control as minor alterations in the peptide sequence. Here, we design a family of pentapeptides and control their selfassembly behaviors, from micro- and nanoparticles to nanofibers and hydrogels. Furthermore, based on the thermodynamics, the gelation kinetics and the ionization status of terminal groups, the peptide assembly goes through five stages as varying the pH value and the assembly structures are highly dependent on the charging status of the terminal groups. The gelation rules of these peptides are further investigated. Besides, we also load hydrophobic functional molecule (curcumin) into different self-assembly nanostructures with high encapsulation efficiency and remarkable thermal and light protection on curcumin. These peptides assemblies with tunable structures, encapsulation ability and photothermal stabilization could become promising candidates for hydrophobic function factor delivery in food industry.
Keyword ：
Curcumin Curcumin Hydrogel Hydrogel Nanoparticle Nanoparticle Peptide Peptide Self-assembly Self-assembly
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| GB/T 7714 | Chen, Huimin , Zhang, Tianrui , Tian, Yongqi et al. Novel self-assembling peptide hydrogel with pH-tunable assembly microstructure, gel mechanics and the entrapment of curcumin [J]. | FOOD HYDROCOLLOIDS , 2022 , 124 . |
| MLA | Chen, Huimin et al. "Novel self-assembling peptide hydrogel with pH-tunable assembly microstructure, gel mechanics and the entrapment of curcumin" . | FOOD HYDROCOLLOIDS 124 (2022) . |
| APA | Chen, Huimin , Zhang, Tianrui , Tian, Yongqi , You, Lijun , Huang, Yan , Wang, Shaoyun . Novel self-assembling peptide hydrogel with pH-tunable assembly microstructure, gel mechanics and the entrapment of curcumin . | FOOD HYDROCOLLOIDS , 2022 , 124 . |
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