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学者姓名：罗芳
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Abstract ：
Detecting of hyaluronidase (HAase) activity is vital in oncology as it drives tumor invasion and metastasis by degrading hyaluronic acid (HA) in the extracellular matrix. In this study, combining a target-responsive hydrogel with magnetic nanozymes, a novel colorimetric sensor was designed for HAase quantification. The composite of Fe₃O₄ and MoS₂ (Fe3O4@MoS2) has magnetism activity and strong peroxidase-like activity, simultaneously has embedded in a hydrogel matrix format from HA, the presence of HAase can specific hydrolysis HA, and caused the rupture of the hydrogel and results in the releasing of the Fe3O4@MoS2. The released Fe3O4@MoS2 can be collected through magnetic separation easily and then applied to catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2, producing a distinct color change, which can be detected by naked eyes easily. The absorbance of the system had a good linear response with HAase concentration within the range of 2.5–90 U/mL, with a limit of detection (LOD) of 1.4 U/mL (S/N = 3). The proposed sensor was successfully applied to detect HAase in serum samples from healthy individuals and pancreatic cancer patients, yielding satisfactory results. © 2025 Elsevier B.V.
Keyword ：
Colorimetric sensor Colorimetric sensor Fe3O4@MoS2 Fe3O4@MoS2 Hyaluronidase Hyaluronidase Target responsive system Target responsive system
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| GB/T 7714 | Yang, J. , Deng, Y. , Chen, Z. et al. Colorimetric sensor for hyaluronidase activity detection based on target-responsive hydrogel embedded with magnetic nanozyme [J]. | Microchemical Journal , 2025 , 216 . |
| MLA | Yang, J. et al. "Colorimetric sensor for hyaluronidase activity detection based on target-responsive hydrogel embedded with magnetic nanozyme" . | Microchemical Journal 216 (2025) . |
| APA | Yang, J. , Deng, Y. , Chen, Z. , Lin, Y. , Chen, D. , Lin, C. et al. Colorimetric sensor for hyaluronidase activity detection based on target-responsive hydrogel embedded with magnetic nanozyme . | Microchemical Journal , 2025 , 216 . |
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The persistence of T-2 toxin in food and feed matrices renders it a pervasive contaminant, impacting both human and animal health. Traditional detection methods suffer from cumbersome instrumentation and intricate procedures, rendering on-site detection of T-2 toxin unfeasible. Therefore, we have constructed a real-time detection method for T-2 toxin detection by employing a target-responsive DNA hydrogel in conjunction with potassium iodide starch test paper. This method integrates both colorimetric and distance-based signal outputs, offering a streamlined and effective approach for the on-site detection of T-2 toxin. The specific binding of the target to the aptamer in the DNA hydrogel results in the collapse of the hydrogels structure, which changes the viscosity of the system and released horseradish peroxidase in the hydrogel wrapped, and then produces blue-purple marks of different lengths on the starch iodide papers to achieve the specific detection of T-2 toxin. Under optimized conditions, the assay exhibits a detection range spanning from 10 ng/mL to 10 mg/mL for the toxin, with a detection limit of 12.83 ng/mL. The proposed method has been successfully applied for the detection of real corn samples with satisfied result. Such colorimetric-distance dual signal detection method offers notable advantages, including straightforward operation, clear signal interpretation, and practical utility. Its implementation enables rapid, on-the-spot detection of T-2 toxin, particularly beneficial in resource-limited regions and less developed countries.
Keyword ：
Point-of-care testing Point-of-care testing Starch iodide paper Starch iodide paper T-2 toxin T-2 toxin Target-responsive DNA hydrogel Target-responsive DNA hydrogel
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| GB/T 7714 | Deng, Ye , Lin, Jiarong , Wang, Jingxuan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper [J]. | MICROCHEMICAL JOURNAL , 2025 , 210 . |
| MLA | Deng, Ye et al. "Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper" . | MICROCHEMICAL JOURNAL 210 (2025) . |
| APA | Deng, Ye , Lin, Jiarong , Wang, Jingxuan , Lin, Yue , Luo, Fang , Weng, Zuquan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper . | MICROCHEMICAL JOURNAL , 2025 , 210 . |
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Real time detection of hydrogen sulfide (H2S) in deep brain regions is of great significance. Photoelectrochemical (PEC) biosensors hold promise for real-time monitoring but low sensitivity due to the use of small electrode restrained its application. In this study, a miniaturized sensor that integrates organic photoelectrochemical transistors (OPECTs) with optical fiber (OF) microelectrodes was designed for the first time, which can amplify the small PEC signal into large channel current change. A conductive gold layer and cuprous oxide nanoparticles (Cu2O NPs) were sequentially deposited onto the OF, followed by a Nafion polymer coating to enhance anti-interference capabilities. Cu2O reacts with H2S to generate Cu2S. The resulting Cu2O/Cu2S heterojunction induces changes in the PEC signal and channel current. Compared to a conventional PEC system, the OPECT sensor has higher sensitivity and lower detection limit, enabling monitoring of H2S concentration fluctuations within the rat brain, which demonstrates the approach's capability for highly sensitive in vivo biomarker detection.
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| GB/T 7714 | Zeng, Yulan , Wang, Xinyang , Chen, Zhonghui et al. Target-Induced Chemical Reaction Modulated Optical Fiber-Gated Organic Photoelectrochemical Transistor for in Vivo H2S Detection [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (13) : 7467-7475 . |
| MLA | Zeng, Yulan et al. "Target-Induced Chemical Reaction Modulated Optical Fiber-Gated Organic Photoelectrochemical Transistor for in Vivo H2S Detection" . | ANALYTICAL CHEMISTRY 97 . 13 (2025) : 7467-7475 . |
| APA | Zeng, Yulan , Wang, Xinyang , Chen, Zhonghui , Luo, Fang , Qiu, Bin , Fu, Fengfu et al. Target-Induced Chemical Reaction Modulated Optical Fiber-Gated Organic Photoelectrochemical Transistor for in Vivo H2S Detection . | ANALYTICAL CHEMISTRY , 2025 , 97 (13) , 7467-7475 . |
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Filling the microchannel with negatively charged hydrogel can exhibit microsacle ion current rectification (ICR) behavior, which is attributed to the space negative charge and structural asymmetry of hydrogel. In this study, this character had been applied to develop a trypsin sensor for the first time. A hydrogel synthesized with bovine serum albumin (BSA) and glyoxal (BSAG hydrogel) was filled at the tip of microchannel firstly. Subsequently, the BSAG hydrogel-filled microchannel was immersed in a trypsin solution to hydrolyze the BSA within the BSAG hydrogel. This process changes the space charge density and pore size of the BSAG hydrogel-filled microchannel, leading to a change in microscale ICR, which can be used for quantifying trypsin. Then the key parameters affecting the sensing performance such as the concentration of BSA, strength of the electrolyte, pH and reaction time were optimized. The detection range was from 10.0 ng/mL to 100 mu g/mL with a detection limit as low as 2.55 ng/mL (S/N = 3). Due to the distinctive three-dimensional pore structure of the hydrogel and the specificity of trypsin for BSA hydrolysis, the sensor exhibits high sensitivity and specificity, as well as remarkable reproducibility and stability. This sensor has been effectively used to measure trypsin levels in human serum samples.
Keyword ：
Hydrogel Hydrogel Microchannel Microchannel Microscale ionic current rectification Microscale ionic current rectification Space negtive charge Space negtive charge Trypsin Trypsin
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| GB/T 7714 | Cai, Huabin , Yuan, Runhao , Huang, Shaokun et al. Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel [J]. | TALANTA , 2025 , 285 . |
| MLA | Cai, Huabin et al. "Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel" . | TALANTA 285 (2025) . |
| APA | Cai, Huabin , Yuan, Runhao , Huang, Shaokun , Huang, Yanling , Lin, Cuiying , Lin, Yue et al. Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel . | TALANTA , 2025 , 285 . |
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Multifunctional hydrogels hold significant promise for promoting the healing of infected wounds but often fall short in inhibiting antibiotic-resistant pathogens, and their clinical translation is limited by complex preparation processes and high costs. In this study, a multifunctional hydrogel is developed by combining metal-phenolic networks (MPNs) formed by tannic acid (TA) and gallium ions (Ga3+) with chitosan (CS) through a simple one-step method. The resulting CS-TA-Ga3+ (CTG) hydrogel is cost-effective and exhibits desirable properties, including injectability, self-healing, pH responsiveness, hemostasis, antioxidant, anti-inflammatory, and antibacterial activities. Importantly, the CTG hydrogels are effective against antibiotic-resistant pathogens due to the unique antibacterial mechanism of Ga3+. In vivo studies demonstrate that the CTG hydrogel promotes follicle formation and collagen deposition, accelerating the healing of infected wounds by inhibiting blood loss, suppressing bacterial growth, and modulating the inflammatory microenvironment. These findings highlight the CTG hydrogel's potential as an advanced and translational dressing for enhancing the healing of infected wounds.
Keyword ：
antibacterial antibacterial gallium ions gallium ions infected wound healing infected wound healing metal-phenolic network metal-phenolic network multifunctional hydrogel multifunctional hydrogel
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| GB/T 7714 | Zou, Minglang , Chen, Cuiping , Wang, Mingda et al. Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing [J]. | ADVANCED HEALTHCARE MATERIALS , 2025 , 14 (9) . |
| MLA | Zou, Minglang et al. "Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing" . | ADVANCED HEALTHCARE MATERIALS 14 . 9 (2025) . |
| APA | Zou, Minglang , Chen, Cuiping , Wang, Mingda , Lei, Chen , Wang, Yongming , Luo, Fang et al. Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing . | ADVANCED HEALTHCARE MATERIALS , 2025 , 14 (9) . |
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The intracellular delivery of protein drugs via nanocarriers offers significant potential for expanding their therapeutic applications. However, the unintended activation of innate immune responses and inflammation triggered by the carriers presents a major challenge, often compromising therapeutic efficacy. Here, we present oligoethylenimine-thioketal (OEI-TK), a reactive oxygen species-responsive cationic polymer with intrinsic anti-inflammatory properties, to overcome this challenge. OEI-TK self-assembles electrostatically with bovine serum albumin (BSA) to form stable nanoparticles (OTB NPs) with excellent encapsulation efficiency. In vitro studies confirmed that OTB NPs retained OEI-TK's antioxidant and anti-inflammatory properties, enhanced biocompatibility, and efficiently delivered BSA into cells. Furthermore, OEI-TK facilitated the intracellular delivery of beta-galactosidase while preserving its enzymatic activity, demonstrating its potential for functional protein transport. These findings highlight OEI-TK as a promising platform with dual benefits of inflammation modulation and intracellular protein delivery, holding potential for the synergistic treatment of inflammation-related diseases.
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| GB/T 7714 | Wang, Yongming , Ming, Yangcan , Yu, Zhichao et al. ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery [J]. | BIOMACROMOLECULES , 2025 , 26 (4) : 2268-2281 . |
| MLA | Wang, Yongming et al. "ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery" . | BIOMACROMOLECULES 26 . 4 (2025) : 2268-2281 . |
| APA | Wang, Yongming , Ming, Yangcan , Yu, Zhichao , Xu, Zhenjin , Zou, Minglang , Chen, Cuiping et al. ROS-Responsive Cationic Polymers with Intrinsic Anti-Inflammatory Activity for Intracellular Protein Delivery . | BIOMACROMOLECULES , 2025 , 26 (4) , 2268-2281 . |
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Herein, we present an innovative electrochemiluminescence (ECL) biosensor for the ultrasensitive detection of N-nitrosodimethylamine (NDMA). The biosensor utilizes a triple signal amplification strategy, combining rolling circle amplification (RCA), CRISPR/Cas12a-driven hyperbranched rolling circle amplification (HRCA), and electrostatic repulsion with size exclusion effects from vertically ordered mesoporous silica film (VMSF)/indium tin oxide (ITO) on double-stranded DNA (dsDNA)-Ru(phen)3 2+ complexes. In this system, aptamers and circular DNA undergo RCA reactions, followed by the CRISPR/Cas12a-mediated HRCA process, producing abundant dsDNA. The electropositive ECL indicator, namely Ru(phen)3 2+, was subsequently adsorbed onto the electronegative dsDNA, forming dsDNA-Ru(phen)3 2+ complexes. These complexes are subjected to electrostatic repulsion and size exclusion by the VMSF-modified ITO electrode, resulting in a lower ECL intensity. Upon introducing NDMA, the aptamer preferentially binds to NDMA, thereby preventing the formation of long dsDNA. This process releases free Ru(phen)3 2+, which diffuses to the electrode surface through narrow mesoporous channels via electrostatic adsorption. Consequently, an enhanced and strong ECL signal is observed. The integration of VMSF enhances selectivity and sensitivity by excluding larger impurities and promoting the electrostatic repulsion of dsDNA-Ru(phen)3 2+ complexes near the electrode surface. Additionally, the CRISPR/Cas12a system eliminates the formation of primer dimers and reduces false positives through its unique cis- and trans-cleavage activities. The biosensor demonstrated excellent performance with a linear correlation between the ECL signal and NDMA concentration in the range spanning from 10 pg/mL to 10 mu g/mL, achieving a low limit of detection of 5.33 pg/mL. This platform offers a reliable and robust solution for detecting NDMA in complex matrices, making it a promising tool for environmental monitoring, public health, and safety applications.
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| GB/T 7714 | Zheng, Zhenjie , Qian, Zhuozhen , Huang, Da et al. Ultrasensitive Homogeneous Electrochemiluminescence Biosensor for N-Nitrosodimethylamine Detection Based on Vertically-Ordered Mesoporous Silica Film-Modified Electrode and CRISPR/Cas12a-Driven HRCA with Triple Signal Amplification [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (10) : 5828-5835 . |
| MLA | Zheng, Zhenjie et al. "Ultrasensitive Homogeneous Electrochemiluminescence Biosensor for N-Nitrosodimethylamine Detection Based on Vertically-Ordered Mesoporous Silica Film-Modified Electrode and CRISPR/Cas12a-Driven HRCA with Triple Signal Amplification" . | ANALYTICAL CHEMISTRY 97 . 10 (2025) : 5828-5835 . |
| APA | Zheng, Zhenjie , Qian, Zhuozhen , Huang, Da , Weng, Zuquan , Wang, Jian , Lin, Cuiying et al. Ultrasensitive Homogeneous Electrochemiluminescence Biosensor for N-Nitrosodimethylamine Detection Based on Vertically-Ordered Mesoporous Silica Film-Modified Electrode and CRISPR/Cas12a-Driven HRCA with Triple Signal Amplification . | ANALYTICAL CHEMISTRY , 2025 , 97 (10) , 5828-5835 . |
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Combined the electrostatic interaction of the negatively charged gold nanorods (AuNRs) (as acceptor) and Ru(bpy)(3)(2+) (as donor), an electrochemiluminescence resonance energy transfer (ECL-RET) sensor was constructed and applied for the detection of organophosphorus pesticides (OPs). Negatively charged AuNRs were synthesized by modifying AuNRs with polystyrene sulfonate (PSS) firstly, which can bind to Ru(bpy)(3)(2+) through electrostatic interaction so that the luminophore was absorbed by the acceptor, the resonance energy transfer occurred and only low ECL signal had been detected. Thiocholine can be produced by the hydrolysis process of acetylthiocholine (ATCh) with the help of acetylcholinesterase (AChE), which can bond with PSS-modified AuNRs (PSS-AuNRs) through gold-sulfur interaction, this caused the releasing of the adsorbed Ru(bpy)(3)(2+) into the solution and resulting in the restoration of the ECL intensity. However, the activity of AChE was inhibited by OPs, and the recovery process of the ECL signal was thus suppressed as well. In this study, chlorpyrifos was chosen as model target, the results indicated that the correlation between the ECL intensity and the logarithm of chlorpyrifos concentration showed remarkable linearity across 1 ng/mL to 1 mg/mL, achieving a detection limit of 0.51 ng/mL. The proposed system has been utilized for detecting OPs in real samples with satisfied results.
Keyword ：
Acetylcholinesterase Acetylcholinesterase Electrochemiluminescence Electrochemiluminescence Gold nanorods Gold nanorods Organophosphorus pesticides Organophosphorus pesticides Resonance energy transfer Resonance energy transfer
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| GB/T 7714 | Li, Zixin , Lin, Zeyu , Chen, Lifen et al. Electrochemiluminescence sensor for organophosphorus pesticides based on the regulation of resonance energy transfer between negative charged gold nanorods and Ru(bpy)32+ [J]. | TALANTA , 2025 , 281 . |
| MLA | Li, Zixin et al. "Electrochemiluminescence sensor for organophosphorus pesticides based on the regulation of resonance energy transfer between negative charged gold nanorods and Ru(bpy)32+" . | TALANTA 281 (2025) . |
| APA | Li, Zixin , Lin, Zeyu , Chen, Lifen , Lin, Yue , Luo, Fang , Lin, Cuiying et al. Electrochemiluminescence sensor for organophosphorus pesticides based on the regulation of resonance energy transfer between negative charged gold nanorods and Ru(bpy)32+ . | TALANTA , 2025 , 281 . |
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Histamine is a kind of biogenic amine released in spoiled food, which can serve as a key indicator for assessing the freshness of seafood. It is important to develop some efficient methods for histamine detection. In this work, a dual-emission europium-metal-organic framework (Eu-MOF) was designed and applied to design a ratiometric fluorescence sensing strategy for histamine detection. The MOF was synthesized in one step using two ligands: 5-boronoisophthalic acid (5-BOP) and 2-hydroxyterephthalic acid (BDC-OH). Eu3+ was sensitized by 5-BOP through the antenna effect and exhibited red emission at 618 nm, while the BDC-OH exhibited bright blue emission at 434 nm. The MOF displayed dual-emission responses to histamine, characterized by an increase in 434 nm and a concomitant decrease at 618 nm, so the ratio of I 618/I 434 decreased with a pronounced fluorescence color shift from purple to blue. I 618/I 434 exhibited a linear range with histamine from 0 to 200 mg/L with a detection limit of 0.17 mg/L (LOD = 3 sigma/KSV). The synthesized Eu-BOP/BDC-OH was integrated with carrageenan to fabricate a hydrogel composite film for portable detection of histamine, and the changing of color can be utilized for semiquantitative freshness detection. The proposed method provided a reliable and efficient portable strategy for histamine detection in seafood.
Keyword ：
histamine histamine hydrogel composite film hydrogel composite film MOF MOF ratiometric fluorescence sensor ratiometric fluorescence sensor seafood freshness seafood freshness
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| GB/T 7714 | Cheng, Mengxin , Cao, Ying , Chen, Lifen et al. Portable Fluorescence Histamine Sensor for Assessing Freshness Utilizing Hydrogel Embedded with Dual-Ligand Europium Metal-Organic Framework [J]. | ACS SENSORS , 2025 , 10 (6) : 4580-4588 . |
| MLA | Cheng, Mengxin et al. "Portable Fluorescence Histamine Sensor for Assessing Freshness Utilizing Hydrogel Embedded with Dual-Ligand Europium Metal-Organic Framework" . | ACS SENSORS 10 . 6 (2025) : 4580-4588 . |
| APA | Cheng, Mengxin , Cao, Ying , Chen, Lifen , Lin, Yue , Luo, Fang , Guo, Longhua et al. Portable Fluorescence Histamine Sensor for Assessing Freshness Utilizing Hydrogel Embedded with Dual-Ligand Europium Metal-Organic Framework . | ACS SENSORS , 2025 , 10 (6) , 4580-4588 . |
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Detection of glutathione (GSH) in the brain provides critical support for investigating the role of GSH in regulating brain function and the mechanism of related diseases. Regulation of the current going through the microchannel can regulate the electrochemiluminescence (ECL) response of the microchannel-based ECL system. In this study, an ECL sensor based on the regulation of wettability of the microchannel was constructed for the first time and successfully applied to detect GSH in the rat brain. The hydrophobic compound bis(triethoxysilylpropyl)disulfide (BTSD) was modified inside the microchannel, and the wettability of the microchannel interface was regulated by the reduction of disulfide bonds in BTSD by GSH, which in turn altered the ionic current and ECL signal of the microchannel-based ECL system. Under optimal conditions, the sensor showed good detection of GSH in the range of 100 nM-10 mM, with a detection limit of 22.4 nM. The sensor has good selectivity and is also reusable. It has been applied to detect GSH in the rat hippocampus with satisfied results.
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| GB/T 7714 | Cai, Huabin , Wu, Peng , Huang, Yanling et al. High Sensitivity and Selectivity Electrochemiluminescence Sensor Based on the Regulation of Wettability in the Microchannel for the Detection of Glutathione in the Rat Brain [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (34) : 18630-18637 . |
| MLA | Cai, Huabin et al. "High Sensitivity and Selectivity Electrochemiluminescence Sensor Based on the Regulation of Wettability in the Microchannel for the Detection of Glutathione in the Rat Brain" . | ANALYTICAL CHEMISTRY 97 . 34 (2025) : 18630-18637 . |
| APA | Cai, Huabin , Wu, Peng , Huang, Yanling , Shou, Jian , Luo, Fang , Lin, Zhenyu et al. High Sensitivity and Selectivity Electrochemiluminescence Sensor Based on the Regulation of Wettability in the Microchannel for the Detection of Glutathione in the Rat Brain . | ANALYTICAL CHEMISTRY , 2025 , 97 (34) , 18630-18637 . |
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