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学者姓名：杨建民
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Abstract ：
Photodynamic therapy (PDT) has emerged as a promising cancer treatment strategy due to its minimally invasive nature and high specificity for malignant tissue. Our previous work has shown that phycocyanobilin (PCB), a natural food coloring derived from Arthrospira Platensis, has the potential to be a photosensitizer. Compared to most reported photosensitizers, PCB is almost non-toxic and readily available. However, its water insolubility and inadequate targeting delivery to cancer cells have been identified as significant obstacles, which compromise its bioavailability and further clinical application. In the present study, Folate-modified pluronic F127 nanoparticle drug delivery system (FF) was developed, which possessed specific tumor targeting, homogeneity, dispersibility and good biocompatibility. This system has been shown to enhance PCB uptake by 4T1 mouse breast carcinoma cells, increase the intracellular ROS production, induce 4T1 cell apoptosis in a concentration-dependent manner, and significantly improve the anticancer activity of PCB. The IC50 value of Phycocyanobilin-Folate acid-pluronic F127 nanoparticle drug delivery system (PFF) under light irradiation was determined to be 42.75 +/- 0.78 mu mol/L, which was 26.62 % higher than that of PCB alone. Zn-Phthalocyanine is a typical second-generation photosensitizer. The therapeutic index (TI) value of PFF was found to be 8.09 under light irradiation, which was significantly higher than that of Zn-Phthalocyanine (TI = 1.08). In vivo studies have shown the efficacy of PFF in delivering PCB to tumor sites, resulting in a significant inhibition rate of tumor growth inhibition (96.15 +/- 3.70 %). Furthermore, PFF has been demonstrated to exhibit excellent biocompatibility, suggesting its potential for use in clinical treatments.
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| GB/T 7714 | Cai, Xuxiang , Hu, Yuhui , Xiao, Siqi et al. Pluronic F127 nanoparticles modified with folate and loaded with phycocyanobilin for tumor-targeted photodynamic therapy [J]. | DYES AND PIGMENTS , 2026 , 245 . |
| MLA | Cai, Xuxiang et al. "Pluronic F127 nanoparticles modified with folate and loaded with phycocyanobilin for tumor-targeted photodynamic therapy" . | DYES AND PIGMENTS 245 (2026) . |
| APA | Cai, Xuxiang , Hu, Yuhui , Xiao, Siqi , Zheng, Yunquan , Yang, Jianmin , Shi, Xianai et al. Pluronic F127 nanoparticles modified with folate and loaded with phycocyanobilin for tumor-targeted photodynamic therapy . | DYES AND PIGMENTS , 2026 , 245 . |
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| GB/T 7714 | Yang, Jianmin , Cai, Fengying , Lv, Yicheng et al. Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024) [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
| MLA | Yang, Jianmin et al. "Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024)" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 297 (2025) . |
| APA | Yang, Jianmin , Cai, Fengying , Lv, Yicheng , Jiang, Ting , Zhao, Xingkai , Hu, Xueli et al. Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024) . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
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Rubropunctatin is a natural and harmless secondary metabolite of the fungus Monascus with promising anticancer properties. However, its water insolubility affects its distribution and absorption in vivo, its bioavailability and further application in the clinic is limited. Herein, a core-shell nano-micelle Rubropunctatin Deoxycholate Sodium/Poloxamer 188/Phospholipid nano-micelle (RDPP-MNPs) was prepared by the film evaporation. RDPP-MNPs exhibited uniform size (152.73 f 1.55 nm), low CMC (0.027 f 0.010 mg/mL) and pHsensitive sustained release, which effectively prolonged the circulation time of the drugs in vivo. The results of CCK-8 cytotoxicity experiment showed that RDPP-MNPs could significantly inhibit the activity of Hela and 4T1 cells (IC50 = 7.73 f 0.09 mu g/mL, IC50 = 9.25 f 0.19 mu g/mL), respectively. In addition, RDPP-MNPs have a greater ability to induce apoptosis of Hela cells by promoting the uptake of drugs into cells in a concentrationdependent manner. Finally, we verified the tumor inhibitory effect and biosafety of RDPP-MNPs by tumorbearing mouse model. The tumor inhibition rate was up to 71.49 f 3.53 % with no systemic toxicity, validated by organ histology. These results showed that the therapeutic efficacy of Rubropunctatin could be significantly enhanced by DPP-MNPs. And based on its good anti-cancer activity, bioavailability and biosafety, it has potential in gentle chemotherapy and can reference other natural compounds in cancer therapy.
Keyword ：
Anticancer Anticancer Gentle chemotherapy Gentle chemotherapy Monascus pigment Monascus pigment Nanomicellar drug delivery system Nanomicellar drug delivery system Rubropunctatin Rubropunctatin
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| GB/T 7714 | Yao, Yuru , Cai, Xuxiang , Zhao, Li et al. Gentler chemotherapy anti-cancer activity based on the Monascus pigment Rubropunctatin loaded in sodium deoxycholate Poloxamer 188 phospholipid micelle nanoparticle drug carrier [J]. | FOOD BIOSCIENCE , 2025 , 69 . |
| MLA | Yao, Yuru et al. "Gentler chemotherapy anti-cancer activity based on the Monascus pigment Rubropunctatin loaded in sodium deoxycholate Poloxamer 188 phospholipid micelle nanoparticle drug carrier" . | FOOD BIOSCIENCE 69 (2025) . |
| APA | Yao, Yuru , Cai, Xuxiang , Zhao, Li , Li, Jiahao , Wang, Beibei , Zheng, Yunquan et al. Gentler chemotherapy anti-cancer activity based on the Monascus pigment Rubropunctatin loaded in sodium deoxycholate Poloxamer 188 phospholipid micelle nanoparticle drug carrier . | FOOD BIOSCIENCE , 2025 , 69 . |
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The inadequate vascularization and abnormal immune microenvironment in the diabetic bone defect region present a significant challenge to osteogenic regulation. Inspired by the distinctive characteristics of healing staged in diabetic bone defects and the structure-function relationship in the natural periosteum, we fabricated an electrospun bilayer biomimetic periosteum (Bilayer@E) to promote regeneration of diabetic bone defects. Here, the inner layer of biomimetic periosteum was fabricated using coaxial electrospinning fibers, with a shell incorporating zinc oxide nanoparticles (ZnO NPs) and a core containing silicon dioxide nanoparticles (SiO2 NPs) mimicking the cambium of periosteum; the outer layer consisted of randomly aligned electrospun fibers loaded with deferoxamine (DFO), simulating the fibrous layer of periosteum; finally, epigallocatechin-3-gallate (EGCG) was coated onto the bilayer membrane to obtain Bilayer@E. The presence of EGCG on the Bilayer@E surface efficiently triggers a phenotypic transition in macrophages, shifting them from an M1 proinflammatory state to an M2 anti-inflammatory state. Moreover, the sequential release of ZnO NPs, DFO, and SiO2 NPs exhibits antimicrobial characteristics while coordinating angiogenesis and promoting osteogenic mineralization in cells. Importantly, the biomimetic periosteum shows strong in vivo bone tissue and periosteal regeneration properties in diabetic rats. The integration of sequential drug release and immunomodulation, tailored to meet the specific healing requirements during bone regeneration, offers new insights for advancing the application of biomaterials in this field.
Keyword ：
biomimetic periosteum biomimetic periosteum bone regeneration bone regeneration diabetesmellitus diabetesmellitus electrospinning electrospinning immunomodulation immunomodulation
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| GB/T 7714 | Zhuang, Yu , Wu, Dingwei , Zhou, Lvyang et al. Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release [J]. | ACS BIOMATERIALS SCIENCE & ENGINEERING , 2025 , 11 (3) : 1690-1704 . |
| MLA | Zhuang, Yu et al. "Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release" . | ACS BIOMATERIALS SCIENCE & ENGINEERING 11 . 3 (2025) : 1690-1704 . |
| APA | Zhuang, Yu , Wu, Dingwei , Zhou, Lvyang , Liu, Boyuan , Zhao, Xingkai , Yang, Jianmin et al. Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release . | ACS BIOMATERIALS SCIENCE & ENGINEERING , 2025 , 11 (3) , 1690-1704 . |
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In anterior cruciate ligament (ACL) repair methods, the continuous enzymatic erosion of synovial fluid can impede healing and potentially lead to repair failure, as well as exacerbate articular cartilage wear, resulting in joint degeneration. Inspired by the blood clot during medial collateral ligament healing, we developed a composite scaffold comprising collagen (1 %, w/v) and polyvinyl alcohol (5 %, w/v) combined with platelet-rich plasma (PRP). The composite scaffold provides a protective barrier against synovial erosion for the ruptured ACL, while simultaneously facilitating tissue repair, thereby enhancing the efficacy of ACL repair techniques. The composite scaffold is primarily formed through hydrogen bonding between molecular chains and physical cross- linking of microcrystalline regions using a simple cyclic freeze-thaw method, resulting in improved mechanical properties and an extended degradation period. The maximum tensile fracture load of the composite scaffold reached 5.99 +/- 0.30 N. The incorporation of PRP facilitates cell migration, proliferation, and blood vessel growth by enabling slow release of various growth factors. In vivo results demonstrate that this composite scaffold promotes rabbit hindlimb rupture ACL healing by stimulating fibroblast proliferation, collagen deposition, microvascular formation, and proprioceptor generation. Furthermore, it effectively reduces meniscus and cartilage wear while mitigating bone arthritis and joint degenerative diseases. Overall, our proposed composite scaffold holds great promise as a candidate for ACL healing.
Keyword ：
Anterior cruciate ligament Anterior cruciate ligament Biodegradable scaffold Biodegradable scaffold Collagen Collagen Platelet-rich plasma Platelet-rich plasma Polyvinyl alcohol Polyvinyl alcohol
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| GB/T 7714 | Sun, Xiaohan , Zhang, Nanxin , Chen, Longhui et al. Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair [J]. | BIOMATERIALS ADVANCES , 2025 , 169 . |
| MLA | Sun, Xiaohan et al. "Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair" . | BIOMATERIALS ADVANCES 169 (2025) . |
| APA | Sun, Xiaohan , Zhang, Nanxin , Chen, Longhui , Lai, Yuchao , Yang, Shasha , Li, Qiang et al. Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair . | BIOMATERIALS ADVANCES , 2025 , 169 . |
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Conventional cotton fiber hemostatic bandages need to passively absorb a large amount of blood due to their high hydrophilicity, resulting in prolonged hemostasis time and increased susceptibility to infection, thereby impeding wound healing. Hence, it is imperative to develop novel hemostatic bandages that can promptly blood clotting while facilitating wound healing. Here a multifunctional composite hemostatic bandage (PSPC) was prepared through in-situ growth technology to anchor silica nanoparticles (SNP) on the polydopamine (PDA) coated chitosan non-woven fabric (CSNF) and combined with polyphosphate (PP). The strong adhesion ability of PDA ensures robust attachment of SNP to the surface of CSNF, thereby significantly reducing particle shedding rate. The PSPC bandage possessed good flexibility, breathability, and mechanical properties, as well as high cytocompatibility and antibacterial properties. Moreover, the synergistic interplay of its multifunctional components promotes rapid blood cell aggregation and actively accelerates the coagulation cascade, significantly enhancing hemostatic performance. In both rat liver and femoral artery injury models, the PSPC exhibited hemostatic efficacy comparable to that of the commercial QuickClot Combat Gauze (R) bandage. Furthermore, the PSPC demonstrated significant efficacy in promoting full-thickness wound healing. These findings suggested the developed hemostatic bandage holds potential for emergency medical applications in resource-limited settings, including battlefield and remote areas.
Keyword ：
Chitosan nonwoven fabric Chitosan nonwoven fabric Hemostatic bandage Hemostatic bandage Polyphosphate Polyphosphate Silica nanoparticles Silica nanoparticles Wound healing Wound healing
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| GB/T 7714 | Cai, Fengying , Liu, Boyuan , Jiang, Ting et al. Chitosan-based hemostatic bandage with in-situ formed silica nanoparticles for rapid bleeding control and wound healing promotion [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2025 , 255 . |
| MLA | Cai, Fengying et al. "Chitosan-based hemostatic bandage with in-situ formed silica nanoparticles for rapid bleeding control and wound healing promotion" . | COLLOIDS AND SURFACES B-BIOINTERFACES 255 (2025) . |
| APA | Cai, Fengying , Liu, Boyuan , Jiang, Ting , Li, Zhendong , Yang, Jianmin , Zheng, Rong . Chitosan-based hemostatic bandage with in-situ formed silica nanoparticles for rapid bleeding control and wound healing promotion . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2025 , 255 . |
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Pressure ulcers, resulting from prolonged external pressure or shear forces on skin and underlying tissues over bony prominences, lead to tissue ischemia and impaired lymphatic drainage. Without timely intervention, these wounds can progress to severe complications including cellulitis, chronic infections, and osteomyelitis. In this study, we developed a chitosan/sodium (3-glycerophosphate/gelatin (CS/(3-GP/GEL) thermosensitive hydrogel system to enhance the therapeutic efficacy of adipose-derived mesenchymal stem cells (ADSCs) in pressure ulcer healing. The incorporation of gelatin addresses the limitations of conventional CS/(3-GP hydrogels, such as low mechanical strength and poor biocompatibility. The optimized CS/(3-GP/GEL hydrogel exhibits good inject-ability, suitable gel formation time and pH, facilitating efficient ADSCs encapsulation. Furthermore, the hydrogel demonstrates good water absorption capacity, degradability, and rheological properties, making it suitable for biomedical applications. In vitro studies confirmed the hydrogel's high cytocompatibility, supporting ADSCs viability and proliferation. Additionally, the CS/(3-GP/GEL@ADSC composite demonstrated pro-angiogenic properties, suppressed reactive oxygen species-mediated apoptosis, and facilitated the accumulation of M2-type macrophages. In vivo evaluations revealed that the CS/(3-GP/GEL@ADSC composite had high histocompatibility and accelerated pressure ulcer healing in a rat model, mediated through enhanced angiogenesis, M2-dominant macrophage polarization, and improved extracellular matrix remodeling. These findings highlight the potential of CS/(3-GP/GEL@ADSC as a promising therapeutic strategy for pressure ulcer management.
Keyword ：
Chitosan Chitosan Mesenchymal stem cell Mesenchymal stem cell Pressure ulcer Pressure ulcer Thermosensitive hydrogel Thermosensitive hydrogel Wound healing Wound healing
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| GB/T 7714 | He, Simeng , Lin, Bin , Zhang, Chenhong et al. Injectable chitosan-based thermosensitive hydrogel loaded with adipose-derived mesenchymal stem cells promotes pressure ulcer healing [J]. | COLLOIDS AND SURFACES B-BIOINTERFACES , 2025 , 256 . |
| MLA | He, Simeng et al. "Injectable chitosan-based thermosensitive hydrogel loaded with adipose-derived mesenchymal stem cells promotes pressure ulcer healing" . | COLLOIDS AND SURFACES B-BIOINTERFACES 256 (2025) . |
| APA | He, Simeng , Lin, Bin , Zhang, Chenhong , He, Shuzhen , Zheng, Yunquan , Shi, Xianai et al. Injectable chitosan-based thermosensitive hydrogel loaded with adipose-derived mesenchymal stem cells promotes pressure ulcer healing . | COLLOIDS AND SURFACES B-BIOINTERFACES , 2025 , 256 . |
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The redox homeostasis defense mechanism of tumor cells is one of the prime reasons for the unsatisfactory effect of photodynamic therapy (PDT). So far, little attention has been paid to this obstacle. In this work, we reported a synthesizing simple yet versatile nanogel (BCPS), synthesized by cystamine dihydrochloride functionalized sodium carboxymethylcellulose (CMC-SS), bovine serum albumin, and Phycocyanobilin self-assembly. The BCPS reduced the levels of glutathione molecules by reacting with glutathione, thereby interfering with intracellular redox homeostasis and enhancing the sensitivity of tumor cells to PDT. The BCPS was shown to possess excellent serum stability, high blood compatibility, low toxic side effects, and higher reactive oxygen species (ROS) utilization. After irradiation, the BCPS could significantly increase intracellular ROS level by approximately 1.6-fold and decrease the IC50 to HeLa cells by approximately 1.5-fold, compared to the pre-functional drugs BCP. This proposed strategy, based on increasing the utilization rate of ROS in tumor cells is promising for application potentials in tumor therapy.
Keyword ：
Green self-assembly Green self-assembly Long-circulating Long-circulating Photodynamic therapy Photodynamic therapy Redox-responsive Redox-responsive Tumor-targeted drug delivery Tumor-targeted drug delivery
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| GB/T 7714 | Liao, Wenqiang , Xiao, Siqi , Yang, Jianmin et al. Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy [J]. | CARBOHYDRATE POLYMERS , 2024 , 323 . |
| MLA | Liao, Wenqiang et al. "Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy" . | CARBOHYDRATE POLYMERS 323 (2024) . |
| APA | Liao, Wenqiang , Xiao, Siqi , Yang, Jianmin , Shi, Xianai , Zheng, Yunquan . Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy . | CARBOHYDRATE POLYMERS , 2024 , 323 . |
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Currently, cisplatin resistance has been recognized as a multistep cascade process for its clinical chemotherapy failure. Hitherto, it remains challenging to develop a feasible and promising strategy to overcome the cascade drug resistance (CDR) issue for achieving fundamentally improved chemotherapeutic efficacy. Herein, a novel self-assembled nanoagent is proposed, which is constructed by Pt(IV) prodrug, cyanine dye (cypate), and gadolinium ion (Gd3+), for systematically conquering the cisplatin resistance by employing near-infrared (NIR) light activated mild-temperature hyperthermia in tumor targets. The proposed nanoagents exhibit high photostability, GSH/H+-responsive dissociation, preferable photothermal conversion, and enhanced cellular uptake performance. In particular, upon 785-nm NIR light irradiation, the generated mild temperature of approximate to 43 degrees C overtly improves the cell membrane permeability and drug uptake, accelerates the disruption of intracellular redox balance, and apparently enhances the formation of Pt-DNA adducts, thereby effectively overcoming the CDR issue and achieves highly improved therapeutic efficacy for cisplatin-resistant tumor ablation. A novel self-assembled nanoagent (Cy-Pt@HA NP) is developed to conquer the cascade drug resistance (CDR) issue of cisplatin. The proposed nanoagent presents NIR light-triggered mild hyperthermia, superior cellular uptake, and tumor-microenvironment-responsive dissociation for effective ablation of drug-resistant tumors, thereby opening a new avenue for addressing CDR issue and maximizing the platinum-based therapeutic efficacy for cancer treatment.image
Keyword ：
cascade cisplatin resistance cascade cisplatin resistance coordination self-assembly coordination self-assembly improved synergistic therapy improved synergistic therapy mild-temperature hyperthermia mild-temperature hyperthermia NIR light-responsive NIR light-responsive
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| GB/T 7714 | Chen, Mingmao , Fu, Yulei , Liu, Yan et al. NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
| MLA | Chen, Mingmao et al. "NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy" . | ADVANCED HEALTHCARE MATERIALS 13 . 11 (2024) . |
| APA | Chen, Mingmao , Fu, Yulei , Liu, Yan , Zhang, Baihe , Song, Xiaorong , Chen, Xinchun et al. NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
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The management of severe full-thickness skin defect wounds remains a challenge due to their irregular shape, uncontrollable bleeding, high risk of infection, and prolonged healing period. Herein, an all-in-one OD/GM/QCS@Exo hydrogel was prepared with catechol-modified oxidized hyaluronic acid (OD), methylacrylylated gelatin (GM), and quaternized chitosan (QCS) and loaded with adipose mesenchymal stem cell-derived exosomes (Exos). Cross-linking of the hydrogel was achieved using visible light instead of ultraviolet light irradiation, providing injectability and good biocompatibility. Notably, the incorporation of catechol groups and multicross-linked networks in the hydrogels conferred strong adhesion properties and mechanical strength against external forces such as tensile and compressive stress. Furthermore, our hydrogel exhibited antibacterial, anti-inflammatory, and antioxidant properties along with wound-healing promotion effects. Our results demonstrated that the hydrogel-mediated release of Exos significantly promotes cellular proliferation, migration, and angiogenesis, thereby accelerating skin structure reconstruction and functional recovery during the wound-healing process. Overall, the all-in-one OD/GM/QCS@Exo hydrogel provided a promising therapeutic strategy for the treatment of full-thickness skin defect wounds through actively participating in the entire process of wound healing.
Keyword ：
all-in-one all-in-one exosomes exosomes multifunctionalhydrogel multifunctionalhydrogel quaternized chitosan quaternized chitosan visible light cross-linkable visible light cross-linkable
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| GB/T 7714 | Lv, Yicheng , Li, Liang , Zhang, Jingyuan et al. Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (20) : 25923-25937 . |
| MLA | Lv, Yicheng et al. "Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process" . | ACS APPLIED MATERIALS & INTERFACES 16 . 20 (2024) : 25923-25937 . |
| APA | Lv, Yicheng , Li, Liang , Zhang, Jingyuan , Li, Jingsi , Cai, Fengying , Huang, Yufeng et al. Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (20) , 25923-25937 . |
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