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学者姓名：陈国南
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Abstract ：
以鲫鱼为代表性研究对象,采用超高效液相色谱-四极杆飞行时间质谱(UPLC-QTOF-MS)技术,分别研究了3种农药(敌百虫、高效氯氰菊酯和吡虫啉)对其体内代谢的影响.通过Masslynx软件在MSE模式下采集数据,使用UNIFI软件进行自动检测和数据过滤,并将差异性物质与在线代谢组数据库进行比较,鉴定出甘油三酯类(TGs)物质具有明显差异.其中,吡虫啉对TGs代谢的影响最大,且肝脏的代谢差异比大脑更显著,低浓度的急性暴露诱导肝脏中的TGs积累,其含量与暴露浓度之间的关系符合Michaelis-Menten方程的增长趋势.结果表明,TGs可在短时间内(≤2 h)灵敏地反映农药吡虫啉的低浓度(≤2...
Keyword ：
农药污染 农药污染 甘油三酯 甘油三酯 生物标记物 生物标记物 超高效液相色谱-四极杆飞行时间质谱 超高效液相色谱-四极杆飞行时间质谱
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| GB/T 7714 | 何聿 , 夏倩 , 王文莉 et al. UPLC-QTOF-MS法研究甘油三酯作为水生环境中农药污染的潜在生物标志物 [J]. | 高等学校化学学报 , 2020 , 41 (03) : 431-438 . |
| MLA | 何聿 et al. "UPLC-QTOF-MS法研究甘油三酯作为水生环境中农药污染的潜在生物标志物" . | 高等学校化学学报 41 . 03 (2020) : 431-438 . |
| APA | 何聿 , 夏倩 , 王文莉 , 罗芳 , 陈金凤 , 郭雅婷 et al. UPLC-QTOF-MS法研究甘油三酯作为水生环境中农药污染的潜在生物标志物 . | 高等学校化学学报 , 2020 , 41 (03) , 431-438 . |
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A novel electrochemiluminescence (ECL) biosensor was developed for high sensitive and selective detection of miRNA-21 based on the efficient and specific toehold-mediated strand displacement (TMSD) amplification with Ru(phen)(3)(2+) loaded DNA nanoclews (NCs-Ru(phen)(3)(2+)) as signal tags. The stable DNA nanoclews, synthesized by a simple rolling circle amplification reaction, were employed to load with Ru(phen)(3)(2+) efficiently as ECL signal tags to amplify the signals. As for TMSD, the substrate strand (Sub) was initially hybridized with P1 and P2 to form DNA duplex structures with a toehold 1. miRNA-21 could hybridize with the toehold 1 and trigger the TMSD amplification with the help of assist strand, releasing lots of P1 stands from DNA duplex structures. The TMSD technique realized the converting and amplification of the single miRNA-21 input to lots of output DNA (namely P1) with good selectivity, simultaneously. Output P1 were designed to expand the stem-locked region of HP, which were immobilized on the Au electrodes firstly. Subsequently, the opened HP could hybridize with the Ru(phen)(3)(2+), capturing the ECL signal tags closed to the sensing surface. The ECL intensity of the system had a linear relationship with the logarithm of the miRNA-21 concentration in the range of 1.0 fM to 100 pM with a limit of detection of 0.65 fM. The strategy was further applied to detect miRNA-21 in complex samples, and the result was consistent with the qRT-PCR.
Keyword ：
DNA nanoclews DNA nanoclews Electrochemiluminescence biosensor Electrochemiluminescence biosensor miRNA-21 miRNA-21 Ru(phen)(3)(2+) Ru(phen)(3)(2+) Toehold-mediated strand displacement Toehold-mediated strand displacement
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| GB/T 7714 | Zhang, Ying , Xu, Guoyan , Lian, Guili et al. Electrochemiluminescence biosensor for miRNA-21 based on toehold-mediated strand displacement amplification with Ru(phen)(3)(2+) loaded DNA nanoclews as signal tags [J]. | BIOSENSORS & BIOELECTRONICS , 2020 , 147 . |
| MLA | Zhang, Ying et al. "Electrochemiluminescence biosensor for miRNA-21 based on toehold-mediated strand displacement amplification with Ru(phen)(3)(2+) loaded DNA nanoclews as signal tags" . | BIOSENSORS & BIOELECTRONICS 147 (2020) . |
| APA | Zhang, Ying , Xu, Guoyan , Lian, Guili , Luo, Fang , Xie, Qunfang , Lin, Zhenyu et al. Electrochemiluminescence biosensor for miRNA-21 based on toehold-mediated strand displacement amplification with Ru(phen)(3)(2+) loaded DNA nanoclews as signal tags . | BIOSENSORS & BIOELECTRONICS , 2020 , 147 . |
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脑神经相关的各种生理和病理过程需在众多生理活性物质的共同参与下完成.硫化氢(H2 S)作为第三类内源性气体信号分子,在维持中枢神经系统正常的生理机能方面起重要的调节作用.因此,在活体层次实现H2 S的精准定量分析,将极大推动人类揭秘脑神经过程中的分子机制的研究进程.然而,H2 S具有较强的还原性和易挥发性,其物理化学性质与脑内含巯基化合物相似,实现H2 S的高选择性的分离分析成为其检测的关键科学问题.本文综述了近年来各类型H2 S检测方法的设计原理及研究进展,对相关研究的发展前景进行了展望.
Keyword ：
活体检测方法 活体检测方法 硫化氢 硫化氢 评述 评述
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| GB/T 7714 | 陈仲辉 , 陈宇 , 翁爱彬 et al. 气体信号分子硫化氢的活体检测方法研究进展 [J]. | 分析化学 , 2019 , 47 (10) : 1572-1579 . |
| MLA | 陈仲辉 et al. "气体信号分子硫化氢的活体检测方法研究进展" . | 分析化学 47 . 10 (2019) : 1572-1579 . |
| APA | 陈仲辉 , 陈宇 , 翁爱彬 , 罗芳 , 郭隆华 , 邱彬 et al. 气体信号分子硫化氢的活体检测方法研究进展 . | 分析化学 , 2019 , 47 (10) , 1572-1579 . |
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Foodborne contaminants widely exist in foods, which can lead to various foodborne diseases and food safety issues. The development of quick, sensitive and universal analytical approaches for foodborne contaminants is imperative. Electrochemiluminescent functional nucleic acids (ECL FNAs)-based sensors are a series of sensing devices using FNAs as the recognition elements and ECL as the transducer. Contributing to the specific recognition ability of FNA and the high sensitivity of ECL, ECL FNA-based sensors are considered to be of great application potential for foodborne contaminants monitoring. This review mainly presents the applications of ECL FNA-based sensors for foodborne contaminants (including microorganisms, mycotoxins, allergens, antibiotics, heavy metal ions, pesticides and some illegal additives). In general, the application of ECL FNA-based sensors in the field of food analysis is just in its infancy. Although there are several limitations and challenges, it is envisaged that ECL FNA-based sensors will have broad prospects for food analysis in the future.
Keyword ：
electrochemiluminescent (ECL) electrochemiluminescent (ECL) foodborne contaminants foodborne contaminants functional nucleic acids (FNAs) functional nucleic acids (FNAs) sensor sensor
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| GB/T 7714 | Xu, Huifeng , Zhu, Xi , Wang, Jian et al. Electrochemiluminescent functional nucleic acids-based sensors for food analysis [J]. | LUMINESCENCE , 2019 , 34 (3) : 308-315 . |
| MLA | Xu, Huifeng et al. "Electrochemiluminescent functional nucleic acids-based sensors for food analysis" . | LUMINESCENCE 34 . 3 (2019) : 308-315 . |
| APA | Xu, Huifeng , Zhu, Xi , Wang, Jian , Lin, Zhenyu , Chen, Guonan . Electrochemiluminescent functional nucleic acids-based sensors for food analysis . | LUMINESCENCE , 2019 , 34 (3) , 308-315 . |
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A copper(II)-based two-dimensional metal-organic framework with nanosheet structure (CuBDC NS) that possesses peroxidase (POx) mimicking activity was prepared. In the presence of hydrogen peroxide, the system catalyses the oxidation of terephthalic acid to a blue-fluorescent product (excitation=315nm; emission=425nm). Pyrophosphate has a very strong affinity for Cu2 ionand blocks the POx-mimicking activity of theCuBDC NS. If, however, inorganic pyrophosphatase is present, the POx mimicking activity is gradually restored because pyrophosphate is hydrolyzed. The findings were used to design a method for the determination of the activity of inorganic pyrophosphataseby fluorometry. Fluorescence increases linearly in the 1-50mU center dot ml-1inorganic pyrophosphatase activity range. The limit of detection is 0.6mU center dot m-1 (S/N=3).
Keyword ：
CuBDC nanosheet CuBDC nanosheet Hydrogen peroxide Hydrogen peroxide Inhibitors Inhibitors Peroxidase mimicking activity Peroxidase mimicking activity Two-dimensional metal-organic frameworks Two-dimensional metal-organic frameworks
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| GB/T 7714 | Hu, Shuisheng , Zhu, Lin , Lam, Cheong Wing et al. Fluorometric determination of the activity of inorganic pyrophosphatase and its inhibitors by exploiting the peroxidase mimicking properties of a two-dimensional metal organic framework [J]. | MICROCHIMICA ACTA , 2019 , 186 (3) . |
| MLA | Hu, Shuisheng et al. "Fluorometric determination of the activity of inorganic pyrophosphatase and its inhibitors by exploiting the peroxidase mimicking properties of a two-dimensional metal organic framework" . | MICROCHIMICA ACTA 186 . 3 (2019) . |
| APA | Hu, Shuisheng , Zhu, Lin , Lam, Cheong Wing , Guo, Longhua , Lin, Zhenyu , Qiu, Bin et al. Fluorometric determination of the activity of inorganic pyrophosphatase and its inhibitors by exploiting the peroxidase mimicking properties of a two-dimensional metal organic framework . | MICROCHIMICA ACTA , 2019 , 186 (3) . |
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Thermometers, one of the most commonly used instruments at home, are normally adapted to measure temperature directly with high accuracy but rarely adopted to act as readout in the biosensors. It is necessary to find some ways to establish a relationship between the concentration of the target and the temperature change. In this study, a common thermometer was used as readout to develop a convenient immunosensor. The designed immunosensor comprises three components, including target recognition area, water flow system, and exothermic reaction bottle. The capture antibody for the target [carcinoembryonic antigen (CEA) was selected as a model target] was preloaded on the bottom of the recognition area. In the presence of CEA, a sandwich-type structure was formed between the capture antibody, CEA, and biotinylated detection antibody. Then, the streptavidin-functionalized platinum nanoparticles were labeled on the detection antibody due to biotin-avidin interaction. The captured platinum nanoparticles can effectively catalyze the decomposition of H2O2 into O-2. The continuous production of gas resulted in pressure increment inside the reaction bottle and further pushed the water flow into the exothermic reaction bottle. Finally, the water reacted with calcium oxide to generate a large amount of heat in the exothermic reaction bottle; thereby the temperature inside the bottle was enhanced and recorded by a common thermometer easily. The temperature enhancement has a linear relationship with the CEA concentration in the range of 7.81-500 pg/mL with a detection limit of 0.6 pg/mL. Furthermore, by taking advantage of simplicity, compatibility, stability, and high sensitivity, our temperature-based immunoassay has been applied to detect CEA in human serum samples with satisfactory results.
Keyword ：
biosensor biosensor cancer diagnosis cancer diagnosis carcinoembryonic antigen carcinoembryonic antigen immunosensor immunosensor temperature temperature thermometer thermometer
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| GB/T 7714 | Ma, Xiaoming , Wang, Zhen , He, Shan et al. Development of an Immunosensor Based on the Exothermic Reaction between H2O and CaO Using a Common Thermometer as Readout [J]. | ACS SENSORS , 2019 , 4 (9) : 2375-2380 . |
| MLA | Ma, Xiaoming et al. "Development of an Immunosensor Based on the Exothermic Reaction between H2O and CaO Using a Common Thermometer as Readout" . | ACS SENSORS 4 . 9 (2019) : 2375-2380 . |
| APA | Ma, Xiaoming , Wang, Zhen , He, Shan , Chen, Chaoqun , Luo, Fang , Guo, Longhua et al. Development of an Immunosensor Based on the Exothermic Reaction between H2O and CaO Using a Common Thermometer as Readout . | ACS SENSORS , 2019 , 4 (9) , 2375-2380 . |
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Lead ions (Pb2+) cause harm to human health. Therefore, the development of fast, effective, and convenient sensors for Pb2+ monitoring has received great attention. In this study, a portable method has been proposed for Pb2+ detection using normal electronic balance as a readout. Magnetic bead-catalytic strand is hybridized with platinum nanoparticles (Pt NPs) functioned substrate strand (Pt-Sub) to form double-stranded DNA first. In the presence of Pb2+, the DNAzyme is activated and cleaved at the ribo-adenosine site of the substrate strand and hence causes Pt NPs to be released into the supernatant, which can be easily separated from the Pt-Sub by a magnet. The separated Pt NPs can effectively catalyze the decomposition of H2O2 to produce O-2. In a sealed bottle, the pressure inside the bottle is increased by the generation of oxygen so that the water is discharged from the drainage device, and the weight of the water can be easily and precisely measured by a normal electronic balance. The weighting water has a linear relationship with the concentration of Pb2+ in the range of 2.5-100 nM and the detection limit of 0.83 nM (S/N = 3). The proposed method has been applied to detect Pb2+ in water with satisfactory results. Because the electronic balance is one of the most commonly used analytical tools for the laboratory, it is very practical and convenient without the need for expensive instruments and complicated data processing.
Keyword ：
electronic balance electronic balance lead ions lead ions magnetic beads magnetic beads platinum nanoparticles platinum nanoparticles portable sensor portable sensor
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| GB/T 7714 | Huang, Yaying , Lin, Cuiying , Luo, Fang et al. Ultrasensitive and Portable Assay for Lead(II) Ions by Electronic Balance as a Readout [J]. | ACS SENSORS , 2019 , 4 (9) : 2465-2470 . |
| MLA | Huang, Yaying et al. "Ultrasensitive and Portable Assay for Lead(II) Ions by Electronic Balance as a Readout" . | ACS SENSORS 4 . 9 (2019) : 2465-2470 . |
| APA | Huang, Yaying , Lin, Cuiying , Luo, Fang , Qiu, Bin , Guo, Longhua , Lin, Zhenyu et al. Ultrasensitive and Portable Assay for Lead(II) Ions by Electronic Balance as a Readout . | ACS SENSORS , 2019 , 4 (9) , 2465-2470 . |
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A surface-enhanced Raman scattering (SERS) substrate with good flexibility and high water absorbing capacity is reported. It consists of a calcium alginate sponge incorporating gold nanoparticles. These are in close contactwith thesponge without the need for amino or sulfhydryl modification. The substrate is capable of detecting the dyes crystal violet (CV) and malachite green (MG) in water directly and rapidly by immersing it into the liquid sample. Preconcentration and separation are not required. The dyes absorbed on the sponge can be detected without drying and thus the whole analytical process can be completed within 3min. The results show that the lowest detectable concentrations are 0.1 and 0.25gL(-1) for CV and MG, respectively. This is lower than the minimum required performance limits set by the European Commission and the US EPA. Moreover, MG and CV can be simultaneously detected in liquid samples due to their different SERS bands (at 1216 and 1534cm(-1), respectively). It should be noted that the molecular structures of MG and CV are very similar. Therefore, the method has a large potential for determination of several analytes simultaneously even in complex sample metrics.
Keyword ：
Crystal violet Crystal violet Gold nanorods Gold nanorods Good flexibility Good flexibility High water absorbing capacity High water absorbing capacity Liquid samples Liquid samples Malachite green Malachite green Metallic nanoparticles Metallic nanoparticles On-site detection On-site detection Rapid analysis Rapid analysis Surface-enhance Raman scattering Surface-enhance Raman scattering
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| GB/T 7714 | Fu, Huiping , Chen, Jiaming , Chen, Lijuan et al. A calcium alginate sponge with embedded gold nanoparticles as a flexible SERS substrate for direct analysis of pollutant dyes [J]. | MICROCHIMICA ACTA , 2019 , 186 (2) . |
| MLA | Fu, Huiping et al. "A calcium alginate sponge with embedded gold nanoparticles as a flexible SERS substrate for direct analysis of pollutant dyes" . | MICROCHIMICA ACTA 186 . 2 (2019) . |
| APA | Fu, Huiping , Chen, Jiaming , Chen, Lijuan , Zhu, Xi , Chen, Zhuling , Qiu, Bin et al. A calcium alginate sponge with embedded gold nanoparticles as a flexible SERS substrate for direct analysis of pollutant dyes . | MICROCHIMICA ACTA , 2019 , 186 (2) . |
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Poly(procaterol hydrochloride) (p-ProH) polymeric film was successfully deposited onto the carboxyl multi-walled carbon nanotube (CMWCNT) modified glass carbon electrode (GCE) to construct a p-ProH/CMWCNT composite modified GCE. Due to the synergistic effect of p-ProH and CMWCNT in the composite, the developed sensor can enormously enhance the oxidation peak current of bromhexine hydrochloride (BrH) at ca. + 0.90 V. Based on this appearance, an electrochemical method was established for the sensitive and selective determination of BrH with differential pulse voltammetry (DPV). Various conditions affecting the peak current response of BrH were studied and optimized. Under the best conditions, the oxidation peak current of BrH is linear to its concentration in two linear dynamic ranges of 0.2-1.0 mol L-1 (R = 0.9948) and 1.0-8.0 mol L-1 (R = 0.9956), with a detection limit of 0.1 mol L-1 (S/N = 3). Interference experiment indicated that the as-prepared electrochemical sensor showed wonderful selectivity to the recognition of BrH and was free from disturbance of many other electro-active substances such as dopamine, ascorbic and uric acid. Finally, the practicability of the BrH sensor was verified by the satisfactory results acquired from the BrH determination in pharmaceutical preparation and human serum.
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| GB/T 7714 | Kong, Dexian , Han, Libin , Wang, Zeming et al. An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi-walled carbon nanotube for the determination of bromhexine hydrochloride [J]. | RSC ADVANCES , 2019 , 9 (21) : 11901-11911 . |
| MLA | Kong, Dexian et al. "An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi-walled carbon nanotube for the determination of bromhexine hydrochloride" . | RSC ADVANCES 9 . 21 (2019) : 11901-11911 . |
| APA | Kong, Dexian , Han, Libin , Wang, Zeming , Jiang, Lili , Zhang, Qian , Wu, Qiong et al. An electrochemical sensor based on poly(procaterol hydrochloride)/carboxyl multi-walled carbon nanotube for the determination of bromhexine hydrochloride . | RSC ADVANCES , 2019 , 9 (21) , 11901-11911 . |
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The quantitative analysis for neurochemistry in living biosystems has drawn extensive attention, because the physiological active substance participates in the transmission of information and relates to physiology and pathology in the brain. Hydrogen sulfide (H2S), as the third gasotransmitter, plays a significant role in the neurophysiology and neuropathology in brain. In vivo detection of H2S will greatly promote the molecular mechanism in the physiology and pathology process. However, H2S have strong reducibility and volatility, and its properties are similar to those of sulfhydryl compounds in the brain. Therefore, selective separation and recognition of H2S from sulfhydryl compounds in the brain is the key scientific issue in the detection of H2S. Herein, the design principle and research progress of various types of H2S detection methods in recent year were reviewed, and an outlook for the future of H2S detection method was propected.
Keyword ：
Hydrogen sulfide Hydrogen sulfide In vivo detection methods In vivo detection methods Review Review
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| GB/T 7714 | Chen Zhong-Hui , Chen Yu , Weng Ai-Bin et al. Research Progress of in Vivo Detection Methods for Gasotransmitter Hydrogen Sulfide [J]. | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2019 , 47 (10) : 1572-1579 . |
| MLA | Chen Zhong-Hui et al. "Research Progress of in Vivo Detection Methods for Gasotransmitter Hydrogen Sulfide" . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 47 . 10 (2019) : 1572-1579 . |
| APA | Chen Zhong-Hui , Chen Yu , Weng Ai-Bin , Luo Fang , Guo Long-Hua , Qiu Bin et al. Research Progress of in Vivo Detection Methods for Gasotransmitter Hydrogen Sulfide . | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY , 2019 , 47 (10) , 1572-1579 . |
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