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学者姓名：陈兆委
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Abstract ：
Pickering emulsions are dispersions of two immiscible liquids stabilized by surface-active colloidal nano-/microparticles. Their compartmentalized structures closely resemble the characteristics of cellular and subcellular systems, enabling the development of biomimetic microreactors that enhance catalytic processes. By enlarging interfacial areas while effectively partitioning reactants into their preferred phases, Pickering emulsion-based microreactors improve kinetic parameters and prevent unwanted interactions. The adaptability of Pickering emulsions is further augmented through modifications to the properties and composition of the particle emulsifiers, rendering them multifunctional and facilitating efficient reactions between immiscible phases, such as oil and water, especially when the emulsifiers themselves act as catalysts. This review summarizes recent advances in Pickering emulsion-based biomimetic microreactors, focusing on the versatile choice of various particles, design principles, and their applications in facilitating biphasic catalysis in a biomimetic way. We also discuss the challenges and future perspectives for further refining these microreactors for enhanced biphasic catalytic processes.
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| GB/T 7714 | Xu, Xiao , Zhou, Min , Wu, Ting et al. Pickering emulsion-based biomimetic microreactors [J]. | MATERIALS CHEMISTRY FRONTIERS , 2025 , 9 (8) : 1290-1311 . |
| MLA | Xu, Xiao et al. "Pickering emulsion-based biomimetic microreactors" . | MATERIALS CHEMISTRY FRONTIERS 9 . 8 (2025) : 1290-1311 . |
| APA | Xu, Xiao , Zhou, Min , Wu, Ting , Chen, Zhaowei , Yang, Huanghao . Pickering emulsion-based biomimetic microreactors . | MATERIALS CHEMISTRY FRONTIERS , 2025 , 9 (8) , 1290-1311 . |
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Treating brain tumors requires a nuanced understanding of the brain, a vital and delicate organ. Location, size, tumor type, and surrounding tissue health are crucial in developing treatment plans. This review comprehensively summarizes various treatment options that are available or could be potentially available for brain tumors, including physical therapies (radiotherapy, ablation therapy, photodynamic therapy, tumor-treating field therapy, and cold atmospheric plasma therapy) and non-physical therapies (surgical resection, chemotherapy, targeted therapy, and immunotherapy). Mechanisms of action, potential side effects, indications, and latest developments, as well as their limitations, are highlighted. Furthermore, the requirements for personalized, multi-modal treatment approaches in this rapidly evolving field are discussed, emphasizing the balance between efficacy and patient safety. The review summarizes various treatment options for brain tumors, focusing on their mechanisms, potential side effects, and recent developments. It emphasizes the need for personalized, multi-modal treatment approaches in this rapidly evolving field, balancing efficacy and patient safety. The complexity and diversity of brain tumor treatments are highlighted, advocating for ongoing research and technological advancements to improve patient outcomes. image
Keyword ：
brain tumor brain tumor cold atmospheric plasma therapy cold atmospheric plasma therapy radiotherapy radiotherapy
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| GB/T 7714 | Bai, Fan , Deng, Yueyang , Li, Long et al. Advancements and challenges in brain cancer therapeutics [J]. | EXPLORATION , 2024 , 4 (6) . |
| MLA | Bai, Fan et al. "Advancements and challenges in brain cancer therapeutics" . | EXPLORATION 4 . 6 (2024) . |
| APA | Bai, Fan , Deng, Yueyang , Li, Long , Lv, Ming , Razzokov, Jamoliddin , Xu, Qingnan et al. Advancements and challenges in brain cancer therapeutics . | EXPLORATION , 2024 , 4 (6) . |
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Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity. However, traditional disposal strategies have limitations, including high energy consumption, use of aggressive reagents and generation of toxic byproducts. Here, inspired by the compartmentalized architecture and detoxification mechanism of bacterial micro-compartments, we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant (2-chloroethyl ethyl sulfide, CEES) under sweet conditions. Two exemplified droplet systems were developed with two-enzyme (glucose oxidase/chloroperoxidase) and three-enzyme (invertase/glucose oxidase/chloroperoxidase) cascades, both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and >99% selectivity towards non-toxic sulfoxide. We found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination efficacy. More importantly, the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles, following long-term storage and in far-field locations.
Keyword ：
bacterial microcompartment bacterial microcompartment biocatalysis biocatalysis biomimetics biomimetics chemical warfare agent chemical warfare agent Pickering emulsion Pickering emulsion
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| GB/T 7714 | Xu, Xiao , Xie, Wenqi , Wu, Ting et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions [J]. | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) : 3039-3049 . |
| MLA | Xu, Xiao et al. "Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions" . | SCIENCE CHINA-CHEMISTRY 67 . 9 (2024) : 3039-3049 . |
| APA | Xu, Xiao , Xie, Wenqi , Wu, Ting , Chen, Chen , Chen, Xiaoning , Yang, Yuheng et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions . | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) , 3039-3049 . |
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Androgenetic alopecia (AGA) is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment, leading to cell apoptosis and eventual loss of hair follicles (HFs). Traditional therapeutic formulations, such as Minoxidil (MXD) tincture, have limitations in reshaping the perifollicular microenvironment and exhibit limited effectiveness. Here, we report a multi-synergistic therapeutic platform for high-performance hair regeneration therapy. The platform combines microneedle (MN) patches loaded with MXD-encapsulated nanostructured lipid carriers (MXD-NLC-MNs) and cold atmospheric plasma (CAP). The MNs' mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells, promoting cell proliferation. Furthermore, in collaboration with MXD, the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor, leading to neoangiogenesis. Meanwhile, the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAP-generated nitric oxide (NO) to the sites of HF lesions, whereby the synergistic interaction between MXD and NO boosts perifollicular vasodilation. Consequently, the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine models. This multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.
Keyword ：
androgenetic alopecia androgenetic alopecia cold atmospheric plasma cold atmospheric plasma drug delivery drug delivery microneedle microneedle nanomedicine nanomedicine
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| GB/T 7714 | Chen, Hao , Tang, Xianzhe , Huang, Yueye et al. Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia [J]. | NANO RESEARCH , 2024 , 17 (7) : 6411-6419 . |
| MLA | Chen, Hao et al. "Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia" . | NANO RESEARCH 17 . 7 (2024) : 6411-6419 . |
| APA | Chen, Hao , Tang, Xianzhe , Huang, Yueye , Chen, Chen , Yang, Yuheng , Hao, Chaojie et al. Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia . | NANO RESEARCH , 2024 , 17 (7) , 6411-6419 . |
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Bacterial biofilm infection is a serious obstacle to clinical therapeutics. Photodynamic therapy (PDT) plays a dynamic role in combating biofilm infection by utilizing reactive oxygen species (ROS)-induced bacterial oxidation injury, showing advantages of mild side effects, spatiotemporal controllability and little drug resistance. However, superfluous glutathione (GSH) present in biofilm and bacteria corporately reduces ROS levels and seriously affects PDT efficiency. Herein, we have constructed a Cu2+-infused porphyrin metal-organic framework (MOF@Cu2+) for the enhanced photodynamic combating of biofilm infection by the maximum depletion of GSH. Our results show that the released Cu2+ from porphyrin MOF@Cu2+ could not only oxidize GSH in biofilm but also consume GSH leaked from ROS-destroyed bacteria, thus greatly weakening the antioxidant system in biofilm and bacteria and dramatically improving the ROS levels. As expected, our dual-enhanced PDT nanoplatform exhibits a strong biofilm eradication ability both in vitro and in an in vivo biofilm-infected mouse model. In addition, Cu2+ can promote biofilm-infected wound closing by provoking cell immigration, collagen sediment and angiogenesis. Besides, no apparent toxicity was detected after treatment with MOF@Cu2+. Overall, our design offers a new paradigm for photodynamic combating biofilm infection.
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| GB/T 7714 | Zhang, Yaoxin , Li, Linpei , Liu, Hui et al. Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (5) : 1317-1329 . |
| MLA | Zhang, Yaoxin et al. "Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm" . | JOURNAL OF MATERIALS CHEMISTRY B 12 . 5 (2024) : 1317-1329 . |
| APA | Zhang, Yaoxin , Li, Linpei , Liu, Hui , Zhang, Haixia , Wei, Menghao , Zhang, Junqing et al. Copper(ii)-infused porphyrin MOF: maximum scavenging GSH for enhanced photodynamic disruption of bacterial biofilm . | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (5) , 1317-1329 . |
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Tumor whole cell, carrying a complete set of tumor-associated antigens and tumor-specific antigens, has shown great potential in the construction of tumor vaccines but is hindered by the complex engineering means and limited efficacy to cause immunity. Herein, we provided a strategy for the self-mineralization of autologous tumor cells with palladium ions in microfluidic droplets, which endowed the engineered cells with both immune and catalytic functions, to establish a bioorthogonally catalytic tumor whole-cell vaccine. This vaccine showed strong inhibition both in the occurrence and recurrence of tumor by invoking the immediate antitumor immunity and building a long-term immunity.
Keyword ：
Bioorthogonal chemistry Bioorthogonal chemistry Immunotherapy Immunotherapy Microfluidics Microfluidics Palladiumnanocatalyst Palladiumnanocatalyst Self-mineralization Self-mineralization
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| GB/T 7714 | Zeng, Fei , Pan, Yongchun , Wu, Mengnan et al. Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy [J]. | ACS NANO , 2024 , 18 (11) : 7923-7936 . |
| MLA | Zeng, Fei et al. "Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy" . | ACS NANO 18 . 11 (2024) : 7923-7936 . |
| APA | Zeng, Fei , Pan, Yongchun , Wu, Mengnan , Lu, Qianglan , Qin, Shurong , Gao, Yanfeng et al. Self-Metallized Whole Cell Vaccines Prepared by Microfluidics for Bioorthogonally Catalyzed Antitumor Immunotherapy . | ACS NANO , 2024 , 18 (11) , 7923-7936 . |
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The physicochemical differences between DNA and other molecules pose a challenge to the construction of DNA based nanostructures. Herein, we propose a straightforward approach for preparing multifunctional DNA-based nanospheres through direct self-assembly of 2'-fluoro-substituted single-stranded DNA (2'F-DNA) with various small molecules. Molecular dynamics simulation revealed that 2'F substitution in DNA can cause the repulsion of adjacent PO(4)(3-)group, leading to local stretching of the DNA structure. Moreover, 2'F substituent induced the regular polarization of H2O nearby F to form the hydration layer, which interrupts inherent interactions among bases. In this way, the bases of 2'F-DNA chain have fewer constraints and more flexibility in conformation, facilitating their non-covalent interactions with other molecules and enhancing the self-assembly capacity of 2'F-DNA. Consequently, 2'F-DNA can bind to more molecules, tending to spontaneously form hybrid DNA nano spheres. Following this approach, a chemo-gene therapy 2'F-DNA/doxorubicin model was designed, showing the significant synergistic anti-tumor therapeutic efficacy. Taken together, this study provides an expandable approach for constructing engineering hybrid nanospheres using DNA and other small molecules, which holds great potential for further biological applications.
Keyword ：
2'F-DNA 2'F-DNA Chemo-gene therapy Chemo-gene therapy Dynamics simulation Dynamics simulation Self-assembly Self-assembly
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| GB/T 7714 | Wang, Haihui , Jiang, Yifan , Liu, Yichang et al. 20.625pt'0.625pt-Fluoro-substituted DNA-induced self-assembly strategy for engineering hybrid nanospheres [J]. | CHEMICAL ENGINEERING JOURNAL , 2023 , 471 . |
| MLA | Wang, Haihui et al. "20.625pt'0.625pt-Fluoro-substituted DNA-induced self-assembly strategy for engineering hybrid nanospheres" . | CHEMICAL ENGINEERING JOURNAL 471 (2023) . |
| APA | Wang, Haihui , Jiang, Yifan , Liu, Yichang , Zhu, Xiaohui , Liu, Yongfei , Chen, Minle et al. 20.625pt'0.625pt-Fluoro-substituted DNA-induced self-assembly strategy for engineering hybrid nanospheres . | CHEMICAL ENGINEERING JOURNAL , 2023 , 471 . |
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The abundant intracellular glutathione (GSH) in cancer cells severely undermines the therapeutic efficacy of different treatments due to their role in protecting cancer cells from the associated oxidative stress. Developing a highly integrated system to consume GSH would help to improve the therapeutic outcomes. In this study, supramolecular prodrug self-assemblies (SPSAs) with IR825 loaded inside were developed to consume GSH via two-pronged pathways while augmenting the therapeutic potency of chemo/photothermal treatment. SPSAs were prepared using water-soluble pillar[6]arene (WP[6]) as host units and H2O2-responsive nitrogen mustard prodrug, chlorambucil-(phenylboronic acid pinacol ester) conjugates (Cb-BE), as the guests. When SPSAs were internalized by cancer cells, the generation of quinone methide (QM) from Cb-BE and singlet oxygen (O-1(2)) from irradiation-activated IR825 could consume GSH in a concerted way. As such, the therapeutic efficacies of the released chlorambucil and the accompanied hyperthermia were augmented toward synergistically inhibiting tumor growth.
Keyword ：
chemo/photothermal therapy chemo/photothermal therapy glutathione consumption glutathione consumption pillar[6]arene pillar[6]arene supramolecular self-assemblies supramolecular self-assemblies
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| GB/T 7714 | Bai, Yang , Li, Xihua , Song, Sijie et al. Pillar[6]arene-based supramolecular self-assemblies for two-pronged GSH-consumption-augmented chemo/photothermal therapy [J]. | NANO RESEARCH , 2023 , 16 (7) : 9921-9929 . |
| MLA | Bai, Yang et al. "Pillar[6]arene-based supramolecular self-assemblies for two-pronged GSH-consumption-augmented chemo/photothermal therapy" . | NANO RESEARCH 16 . 7 (2023) : 9921-9929 . |
| APA | Bai, Yang , Li, Xihua , Song, Sijie , Yang, Jing , Liu, Xia , Chen, Zhaowei . Pillar[6]arene-based supramolecular self-assemblies for two-pronged GSH-consumption-augmented chemo/photothermal therapy . | NANO RESEARCH , 2023 , 16 (7) , 9921-9929 . |
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Bioorthogonal catalysis, a class of catalytic reactions that are mediated by abiotic metals and proceed in biological environments without interfering with native biochemical reactions, has gained ever-increasing momentum in prodrug delivery over the past few decades. Albeit great progress has been attained in developing new bioorthogonal catalytic reactions and optimizing the catalytic performance of transition metal catalysts (TMCs), the use of TMCs to activate chemotherapeutics at the site of interest in vivo remains a challenging endeavor. To translate the bioorthogonal catalysis-mediated prodrug activation paradigm from flasks to animals, TMCs with targeting capability and stimulus-responsive behavior have been well-designed to perform chemical transformations in a controlled manner within highly complex biochemical systems, rendering on-demand drug activation to mitigate off-target toxicity. Here, we review the recent advances in the development of controllable bioorthogonal catalysis systems, with an emphasis on different strategies for engineering TMCs to achieve precise control over prodrug activation. Furthermore, we outline the envisaged challenges and discuss future directions of controllable bioorthogonal catalysis for disease therapy. This Feature Article summarizes the recent progress in prodrug activation mediated by controllable bioorthogonal catalysis.
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| GB/T 7714 | Liu, Xia , Huang, Tingjing , Chen, Zhaowei et al. Progress in controllable bioorthogonal catalysis for prodrug activation [J]. | CHEMICAL COMMUNICATIONS , 2023 , 59 (84) : 12548-12559 . |
| MLA | Liu, Xia et al. "Progress in controllable bioorthogonal catalysis for prodrug activation" . | CHEMICAL COMMUNICATIONS 59 . 84 (2023) : 12548-12559 . |
| APA | Liu, Xia , Huang, Tingjing , Chen, Zhaowei , Yang, Huanghao . Progress in controllable bioorthogonal catalysis for prodrug activation . | CHEMICAL COMMUNICATIONS , 2023 , 59 (84) , 12548-12559 . |
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Apoptosis has gained increasing attention in cancer therapy as an intrinsic signaling pathway, which leads to minimal leakage of waste products from a dying cell to neighboring normal cells. Among various stimuli to trigger apoptosis, mild hyperthermia is attractive but confronts limitations of non-specific heating and acquired resistance from elevated expression of heat shock proteins. Here, a dual-stimulation activated turn-on T-1 imaging-based nanoparticulate system (DAS) is developed for mild photothermia (& AP;43 & DEG;C)-mediated precise apoptotic cancer therapy. In the DAS, a superparamagnetic quencher (ferroferric oxide nanoparticles, Fe3O4 NPs) and a paramagnetic enhancer (Gd-DOTA complexes) are connected via the N6-methyladenine (m(6)A)-caged, Zn2+-dependent DNAzyme molecular device. The substrate strand of the DNAzyme contains one segment of Gd-DOTA complex-labeled sequence and another one of HSP70 antisense oligonucleotide. When the DAS is taken up by cancer cells, overexpressed fat mass and obesity-associated protein (FTO) specifically demethylates the m(6)A group, thereby activating DNAzymes to cleave the substrate strand and simultaneously releasing Gd-DOTA complex-labeled oligonucleotides. The restored T-1 signal from the liberated Gd-DOTA complexes lights up the tumor to guide the location and time of deploying 808 nm laser irradiation. Afterward, locally generated mild photothermia works in concert with HSP70 antisense oligonucleotides to promote apoptosis of tumor cells. This highly integrated design provides an alternative strategy for mild hyperthermia-mediated precise apoptotic cancer therapy.
Keyword ：
apoptosis apoptosis DNAzymes DNAzymes gene therapy gene therapy MRI MRI photothermal therapy photothermal therapy
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| GB/T 7714 | Song, Sijie , Wang, Qi , Xie, Jiangao et al. Dual-Responsive Turn-On T-1 Imaging-Guided Mild Photothermia for Precise Apoptotic Cancer Therapy [J]. | ADVANCED HEALTHCARE MATERIALS , 2023 , 12 (28) . |
| MLA | Song, Sijie et al. "Dual-Responsive Turn-On T-1 Imaging-Guided Mild Photothermia for Precise Apoptotic Cancer Therapy" . | ADVANCED HEALTHCARE MATERIALS 12 . 28 (2023) . |
| APA | Song, Sijie , Wang, Qi , Xie, Jiangao , Dai, Junduan , Ouyang, Dilan , Huang, Guoming et al. Dual-Responsive Turn-On T-1 Imaging-Guided Mild Photothermia for Precise Apoptotic Cancer Therapy . | ADVANCED HEALTHCARE MATERIALS , 2023 , 12 (28) . |
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