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学者姓名：郭翠霞
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Abstract ：
The strong scattering and time variability of dynamic scattering media pose a major challenge to optical focusing and imaging applications. In this paper, a feedback wavefront shaping technology based on digital micromirror devices is proposed, which combines the hardware design and algorithm optimization. Through a new hardware- triggered image acquisition system and dynamic subgroup genetic algorithm, the image acquisition rate and focusing efficiency are significantly improved, and the light is quickly focused in dynamic turbid water. The imaging speed is about 34.89 times that of the traditional method based on a software-triggered image acquisition system and genetic algorithm. The experimental results of focusing through a milk solution show that this technique has a remarkable effect in improving the efficiency of dynamic focusing and the light intensity of focusing region, which provides an effective optimization strategy for optical imaging technology through a dynamic scattering medium in the future. (c) 2025 Optica Publishing Group. All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved.
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| GB/T 7714 | Guo, Cuixia , Zou, Zhanghuang , Liu, Yu et al. Rapid focusing of light through turbid water based on a digital micromirror device [J]. | APPLIED OPTICS , 2025 , 64 (4) : 917-926 . |
| MLA | Guo, Cuixia et al. "Rapid focusing of light through turbid water based on a digital micromirror device" . | APPLIED OPTICS 64 . 4 (2025) : 917-926 . |
| APA | Guo, Cuixia , Zou, Zhanghuang , Liu, Yu , Yu, Min , Huang, Feng . Rapid focusing of light through turbid water based on a digital micromirror device . | APPLIED OPTICS , 2025 , 64 (4) , 917-926 . |
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| GB/T 7714 | Guo, Cuixia , Ye, Ziling , He, Yonghong et al. Thickness and fluorescence-based dual-encoded suspension array and corresponding decoding system for multiplexed detection (vol 388, 133793, 2023) [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 424 . |
| MLA | Guo, Cuixia et al. "Thickness and fluorescence-based dual-encoded suspension array and corresponding decoding system for multiplexed detection (vol 388, 133793, 2023)" . | SENSORS AND ACTUATORS B-CHEMICAL 424 (2025) . |
| APA | Guo, Cuixia , Ye, Ziling , He, Yonghong , Huang, Zeyu , Zhang, Hongjian , Huang, Feng . Thickness and fluorescence-based dual-encoded suspension array and corresponding decoding system for multiplexed detection (vol 388, 133793, 2023) . | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 424 . |
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The demand for accurate and efficient immunoassays calls for the development of precise, high-throughput analysis methods. This paper introduces a novel approach utilizing a weak measurement interface sensor for immunoassays, offering a solution for high throughput analysis. Weak measurement is a precise quantum measurement method that amplifies the weak value of a system in the weak interaction through appropriate pre- and post-selection states. To facilitate the simultaneous analysis of multiple samples, we have developed a chip with six flow channels capable of conducting six immunoassays concurrently. We can perform real-time immunoassay to determine the binding characteristics of spike protein and antibody through real-time analysis of the flow channel images and calculating the relative intensity. The proposed method boasts a simple structure, eliminating the need for intricate nano processes. The spike protein concentration and relative intensity curve were fitted using the Log-Log fitting regression equation, and R2 was 0.91. Utilizing a pre-transformation approach to account for slight variations in detection sensitivity across different flow channels, the present method achieves an impressive limit of detection(LOD) of 0.85 ng/mL for the SARS-CoV-2 the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, with a system standard deviation of 5.61. Furthermore, this method has been successfully verified for monitoring molecular-specific binding processes and differentiating binding capacities. © 2024 by the authors.
Keyword ：
high throughput immunoassay high throughput immunoassay optical biosensor optical biosensor SARS-CoV-2 spike protein SARS-CoV-2 spike protein weak measurement weak measurement
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| GB/T 7714 | Zhang, X. , Zhang, L. , Li, H. et al. Weak Value Amplification Based Optical Sensor for High Throughput Real-Time Immunoassay of SARS-CoV-2 Spike Protein [J]. | Biosensors , 2024 , 14 (7) . |
| MLA | Zhang, X. et al. "Weak Value Amplification Based Optical Sensor for High Throughput Real-Time Immunoassay of SARS-CoV-2 Spike Protein" . | Biosensors 14 . 7 (2024) . |
| APA | Zhang, X. , Zhang, L. , Li, H. , Xu, Y. , Meng, L. , Liang, G. et al. Weak Value Amplification Based Optical Sensor for High Throughput Real-Time Immunoassay of SARS-CoV-2 Spike Protein . | Biosensors , 2024 , 14 (7) . |
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叶黄素是天然的抗氧化剂,对人体健康有多种益处,异养小球藻具有叶黄素纯度和产量均较高的优势,而小球藻叶黄素产量主要取决于生物质产量和叶黄素含量两个因素.传统的光密度法测生物质产量和高效液相色谱法测叶黄素含量存在操作复杂、时效性低等不足.为了快速、无损测定小球藻生长过程中叶黄素含量变化,搭建可见-近红外双模式快照式多光谱成像检测系统,根据光谱响应区域,分别利用可见光相机获取叶黄素光谱信息,近红外相机获取生物质光谱信息,构建含有生物质量和叶黄素含量信息的可见-近红外双模式多光谱数据集.针对系统所使用的快照式多光谱相机光谱范围宽、波长数量少的特征波长选取问题,提出一种结合序列浮动前向选择的改进型连续投影算法(mSPA);将mSPA与常规的连续投影算法、遗传算法及随机蛙跳三种波长选择算法作对比分析后,构建了基于特征波长的多元线性回归和极限学习机模型;最后,利用生物质产量和叶黄素含量的最佳预测模型生成小球藻叶黄素产量的可视化分布图.结果表明,在利用近红外、可见光相机分别检测小球藻生物质、叶黄素量时,mSPA得到的特征波长数均较少,并具有最高的预测精度.生物质量与叶黄素含量的最佳模型均为mSPA筛选特征波长后建立的极限学习机模型,对应的预测集决定系数分别为0.947和0.907,预测集均方根误差分别为0.698 g·L-1和0.077 mg·g-1,剩余预测偏差分别为3.535和3.338,模型的预测能力较好.可视化分布实现了直观监测小球藻叶黄素产量的变化,有助于后续实际生产中在线检测叶黄素产量.mSPA在快照式多光谱检测小球藻生物质含量及叶黄素含量中,通过对排序波长逐个评估以选择出最佳特征波长组合,有效地避免了特征波长的错选、漏选,提高了模型的预测精度,为快照式多光谱成像技术应用提供新的波长选择思路.
Keyword ：
叶黄素产量 叶黄素产量 小球藻 小球藻 快照式多光谱 快照式多光谱 特征波长 特征波长
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| GB/T 7714 | 沈英 , 占秀兴 , 黄春红 et al. 基于快照式多光谱特征波长的小球藻叶黄素产量快速测定 [J]. | 光谱学与光谱分析 , 2024 , 44 (8) : 2216-2223 . |
| MLA | 沈英 et al. "基于快照式多光谱特征波长的小球藻叶黄素产量快速测定" . | 光谱学与光谱分析 44 . 8 (2024) : 2216-2223 . |
| APA | 沈英 , 占秀兴 , 黄春红 , 谢友坪 , 郭翠霞 , 黄峰 . 基于快照式多光谱特征波长的小球藻叶黄素产量快速测定 . | 光谱学与光谱分析 , 2024 , 44 (8) , 2216-2223 . |
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The precise biomolecular detection is crucial in medical diagnosis, biological research, and bioengineering. In this article, a phase multiplexing-based molecularly imprinted polymer biosensor (PM-MIPB) is proposed. It considers the high-throughput and nonlabeling detection mode by multiplexing without increasing the number of scanning and detecting elements, as well as the high specificity and affinity of molecular imprinting technology (MIT), to improve the throughput and accuracy of molecular detection. Phase multiplexing originates from phase-sensitive spectral-domain optical coherence tomography, where the low-coherence interferometric spectra with multiple optical path differences are spectrally analyzed to identify and extract the interferometric phases across these paths. Based on this principle, simultaneous quantitative detection and interaction analysis of multiple analytes can be realized by preparing multiple optical-path difference-encoded (also thickness-encoded) detection channels and simultaneously extracting the phases of the interfering signals. Furthermore, the PM-MIPB utilizes molecularly imprinted polymer as an alternative to antigen-antibody systems, creating selective recognition sites through specific template molecules to achieve highly selective, specific, and stable detection of target molecules. Theoretically, the PM-MIPB can simultaneously measure up to 255 biomolecules, with a detection speed of 0.025 s, recovery rate ranging from 95.65% to 103.41%, and sensitivity of 4.05x10(-3) nm center dot mL/mu g. By integrating phase multiplexing with molecular imprinting, the PM-MIPB meets the high demand for efficient, high throughput, and accurate biomolecular detection in the life science field.
Keyword ：
Biomedical optical imaging Biomedical optical imaging Biosensor Biosensor Biosensors Biosensors Interference Interference molecular imprinting molecular imprinting Multiplexing Multiplexing optical coherence tomography optical coherence tomography Optical interferometry Optical interferometry Optical sensors Optical sensors phase multiplexing phase multiplexing Sensors Sensors
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| GB/T 7714 | Guo, Cuixia , Pan, Zhijie , Huang, Zeyu et al. Phase Multiplexing-Based Molecular Imprint Biosensor [J]. | IEEE SENSORS JOURNAL , 2024 , 24 (20) : 31763-31772 . |
| MLA | Guo, Cuixia et al. "Phase Multiplexing-Based Molecular Imprint Biosensor" . | IEEE SENSORS JOURNAL 24 . 20 (2024) : 31763-31772 . |
| APA | Guo, Cuixia , Pan, Zhijie , Huang, Zeyu , Zou, Zhanghuang , Huang, Feng . Phase Multiplexing-Based Molecular Imprint Biosensor . | IEEE SENSORS JOURNAL , 2024 , 24 (20) , 31763-31772 . |
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In this work, we present a reverse-design method for 1-D disordered waveguide structures which might be used for future terahertz on-chip integrated systems. This method is based on the Anderson localization effect to construct the initial structure of the waveguides. Due to the probability statistical distribution, the waveguides with randomly generated fluctuations have different localization abilities. We optimized the refractive index fluctuations and distributions of the waveguide structure through intelligent reverse-design algorithms and ultimately obtained the optimal structural parameters. Simulation results indicate that the optimized waveguide has a better localization ability, a lower insertion loss, and a good robustness against fabrication errors and defects compared to the initial waveguide.
Keyword ：
Anderson localization Anderson localization Biomedical optical imaging Biomedical optical imaging Electric fields Electric fields Fluctuations Fluctuations Location awareness Location awareness Optical fibers Optical fibers Optical waveguides Optical waveguides Refractive index Refractive index reverse-design reverse-design terahertz terahertz waveguide waveguide
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| GB/T 7714 | Chen, Yanqing , Qin, Binhua , Liang, Beiyuan et al. Reverse Design of Terahertz Waveguide Structures Based on Anderson Localization [J]. | IEEE TRANSACTIONS ON PLASMA SCIENCE , 2024 . |
| MLA | Chen, Yanqing et al. "Reverse Design of Terahertz Waveguide Structures Based on Anderson Localization" . | IEEE TRANSACTIONS ON PLASMA SCIENCE (2024) . |
| APA | Chen, Yanqing , Qin, Binhua , Liang, Beiyuan , Ju, Xuewei , Guo, Cuixia , Huang, Feng et al. Reverse Design of Terahertz Waveguide Structures Based on Anderson Localization . | IEEE TRANSACTIONS ON PLASMA SCIENCE , 2024 . |
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In this work, magnetic nanocomposite films were prepared using magnetorheological fluids and were characterized by time-domain terahertz spectroscopy. Applying magnetic field during the curing process of magnetorheological fluids makes Fe nanoparticles align into a chain-like structure. Permanent anisotropy is solidified in the films, resulting in a birefringence coefficient as high as 0.37 in a frequency range from 0.4 to 2.0 THz. The polarization state of terahertz wave can be converted by rotating the film at room temperature without external magnetic field. When the rotation angle is at 50 degrees- 60 degrees, the ellipticity is greater than 0.8 in the frequency range of 1.19-1.6 THz, indicating that the film can be used as a quarter waveplate.
Keyword ：
Birefringence coefficient Birefringence coefficient magnetorheologicalfluid (MRF) magnetorheologicalfluid (MRF) nanocomposite nanocomposite time-domain terahertz spectroscopy time-domain terahertz spectroscopy
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| GB/T 7714 | Chen, Yanqing , Zhu, Guofeng , Huang, Feng et al. Large Terahertz Birefringence in Nanocomposite Films Made From Magnetorheological Fluid [J]. | IEEE TRANSACTIONS ON PLASMA SCIENCE , 2024 . |
| MLA | Chen, Yanqing et al. "Large Terahertz Birefringence in Nanocomposite Films Made From Magnetorheological Fluid" . | IEEE TRANSACTIONS ON PLASMA SCIENCE (2024) . |
| APA | Chen, Yanqing , Zhu, Guofeng , Huang, Feng , Ju, Xuewei , Wang, Jiaxun , Guo, Cuixia et al. Large Terahertz Birefringence in Nanocomposite Films Made From Magnetorheological Fluid . | IEEE TRANSACTIONS ON PLASMA SCIENCE , 2024 . |
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TmFeO3 具有磁光效应、多铁性和自旋重取向等丰富的物理特性,在凝聚态物理和材料物理领域具有重要的研究价值.本文利用时域太赫兹低温磁光谱,研究 TmFeO3 单晶在 1.6 K温度下自旋共振频率随外加磁场的变化规律,并表征其内部复杂的相互作用.结果表明,随磁场增加TmFeO3 单晶的准铁磁共振向高频移动,而准反铁磁共振在临界磁场(2.2-3.6 T)转变为准铁磁共振,通过磁结构分析和理论拟合,证实单晶磁矩发生了磁场诱导的自旋重取向.本研究有助于深入理解稀土正铁氧体在外磁场、温度场综合作用下,内部磁结构的调控机制,开发相关的自旋电子学器件.
Keyword ：
太赫兹 太赫兹 稀土正铁氧体 稀土正铁氧体 自旋重取向 自旋重取向 铁磁共振 铁磁共振
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| GB/T 7714 | 王宁 , 黄峰 , 陈盈 et al. 磁场诱导的TmFeO3单晶自旋重取向 [J]. | 物理学报 , 2024 , 73 (1) : 298-304 . |
| MLA | 王宁 et al. "磁场诱导的TmFeO3单晶自旋重取向" . | 物理学报 73 . 1 (2024) : 298-304 . |
| APA | 王宁 , 黄峰 , 陈盈 , 朱国锋 , 苏浩斌 , 郭翠霞 et al. 磁场诱导的TmFeO3单晶自旋重取向 . | 物理学报 , 2024 , 73 (1) , 298-304 . |
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TmFeO3 exhibits rich physical properties such as magneto -optical effect, multiferroicity, and spin reorientation, making it possess significant research value in condensed matter physics and materials science. In this study, we utilize a time -domain terahertz magneto -optical spectroscopy system to investigate the changes in spin resonance frequency of TmFeO3 single crystal at T = 1.6 K under external magnetic fields in a range of 0-7 T. The TmFeO3 sample is grown in an optical floating zone furnace and its crystallographic orientation is determined by using back -reflection Laue X-ray photography with a tungsten target. The measurement setup is a self -built time -domain terahertz magneto -optical spectroscopy system, with magnetic fields in a range of 0- 7 T, temperatures in a range of 1.6-300 K, and a spectral range of 0.2-2.0 THz. A pair of 1 mm -thick ZnTe nonlinear crystals is used to generate and detect terahertz signals through optical rectification and electro-optic sampling technique. The system variable temperature and magnetic field are controlled by a superconducting magnet. In experiments, a linearly polarized terahertz wave is vertically incident on the sample surface, and its magnetic component HTHz is parallel to the sample surface. By rotating the sample, the angle (0) between macroscopic magnetic moment M and HTHz can be tuned, achieving selective excitations of the two modes, that is, 0 = 0 for q-AFM mode and 90 degrees for q -FM mode. Terahertz absorption spectrum results indicate that as the magnetic field increases, the quasi -ferromagnetic resonance (q -FM) of TmFeO3 single crystal shifts towards high frequencies, and quasi-antiferromagnetic resonance (q-AFM) transits to q -FM under low critical magnetic fields (2.2-3.6 T). Through magnetic structure analysis and theoretical fitting, it is confirmed that the magnetic moment of the single crystal undergoes magnetic field induced spin reorientation. This study is helpful in better understanding of the regulation mechanism of the internal magnetic structure of rare earth ferrite under the combined action of external magnetic field and temperature field, and also in developing related spin electronic devices.
Keyword ：
ferromagnetic resonance ferromagnetic resonance rare earth orthoferrite rare earth orthoferrite spin reorientation spin reorientation terahertz terahertz
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| GB/T 7714 | Wang, Ning , Huang, Feng , Chen, Ying et al. Magnetic-field-induced spin reorientation in TmFeO3 single crystals [J]. | ACTA PHYSICA SINICA , 2024 , 73 (1) . |
| MLA | Wang, Ning et al. "Magnetic-field-induced spin reorientation in TmFeO3 single crystals" . | ACTA PHYSICA SINICA 73 . 1 (2024) . |
| APA | Wang, Ning , Huang, Feng , Chen, Ying , Zhu, Guo-Feng , Su, Hao-Bin , Guo, Cui-Xia et al. Magnetic-field-induced spin reorientation in TmFeO3 single crystals . | ACTA PHYSICA SINICA , 2024 , 73 (1) . |
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Most of the state-of-the-art defogging models presented in the literature assume that the attenuation coefficient of all spectral channels is constant, which inevitably leads to spectral distortion and information bias. To address this issue, this paper proposes a defogging method that takes into account the difference between the extinction coefficients of multispectral channels of light traveling through fog. Then the spatially distributed transmission map of each spectral channel is reconstructed to restore the fog-degraded images. The experimental results of various realistic complex scenes show that the proposed method has more outstanding advantages in restoring lost detail, compensating for degraded spectral information, and recognizing more targets hidden in uniform ground fog than state-of-the-art technologies. In addition, this work provides a method to characterize the intrinsic property of fog expressed as multispectral relative extinction coefficients, which act as a fundament for further reconstruction of multispectral information. (c) 2024 Optica Publishing Group
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| GB/T 7714 | Huang, Feng , Ke, Chaozhen , Wu, Xianyu et al. Multispectral image defogging based on a wavelength-dependent extinction coefficient model in fog [J]. | JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION , 2024 , 41 (4) : 631-642 . |
| MLA | Huang, Feng et al. "Multispectral image defogging based on a wavelength-dependent extinction coefficient model in fog" . | JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION 41 . 4 (2024) : 631-642 . |
| APA | Huang, Feng , Ke, Chaozhen , Wu, Xianyu , Guo, Cuixia , Liu, Yu . Multispectral image defogging based on a wavelength-dependent extinction coefficient model in fog . | JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION , 2024 , 41 (4) , 631-642 . |
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