Query：
学者姓名：游毅
Refining：
Year
Type
Indexed by
Source
Complex
Former Name
Co-
Language
Clean All
Abstract ：
A new and efficient method is developed for the synthesis of 2-trifluoromethyl benzimidazoles, benzoxazoles, and benzothiazoles in good to excellent yields by the condensation of diamines or amino(thio)phenols with in situ generated CF3CN. Additionally, the synthetic utility of the 2-trifluoromethyl benzimidazole and benzoxazole products is demonstrated via gram scale synthesis. The mechanistic study suggests that the reaction proceeds via the nucleophilic addition of trifluoroacetonitrile to the amino group of the diamine derivatives to form an imidamide intermediate, followed by intramolecular cyclization.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lin, Bo , Yao, Yunfei , Wu, Minze et al. Synthesis of 2-trifluoromethyl benzimidazoles, benzoxazoles, and benzothiazoles via condensation of diamines or amino(thio)phenols with CF3CN [J]. | ORGANIC & BIOMOLECULAR CHEMISTRY , 2023 , 21 (23) : 4788-4793 . |
| MLA | Lin, Bo et al. "Synthesis of 2-trifluoromethyl benzimidazoles, benzoxazoles, and benzothiazoles via condensation of diamines or amino(thio)phenols with CF3CN" . | ORGANIC & BIOMOLECULAR CHEMISTRY 21 . 23 (2023) : 4788-4793 . |
| APA | Lin, Bo , Yao, Yunfei , Wu, Minze , Qin, Lu , Chen, Shouxiong , You, Yi et al. Synthesis of 2-trifluoromethyl benzimidazoles, benzoxazoles, and benzothiazoles via condensation of diamines or amino(thio)phenols with CF3CN . | ORGANIC & BIOMOLECULAR CHEMISTRY , 2023 , 21 (23) , 4788-4793 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A copper-mediated three-component reaction of o-iodoanilines, anilines, and ethyl trifluoropyruvate is reported. The transformation allows diverse substrate scope on both o-iodoanilines and anilines, delivering various 2-trifluoromethylbenzimidazole products in moderate to good yields. Mechanistic studies suggest that this transformation proceeds via condensation of o-iodoaniline with ethyl trifluoropyruvate, followed by an intermolecular Ullmann-type cross-coupling reaction with aniline and intramolecular amination.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | You, Chenhui , Huang, Yangjie , You, Yi et al. Copper-mediated three-component synthesis of 2-trifluoromethyl benzimidazoles [J]. | ORGANIC CHEMISTRY FRONTIERS , 2022 , 9 (12) : 3247-3254 . |
| MLA | You, Chenhui et al. "Copper-mediated three-component synthesis of 2-trifluoromethyl benzimidazoles" . | ORGANIC CHEMISTRY FRONTIERS 9 . 12 (2022) : 3247-3254 . |
| APA | You, Chenhui , Huang, Yangjie , You, Yi , Weng, Zhiqiang . Copper-mediated three-component synthesis of 2-trifluoromethyl benzimidazoles . | ORGANIC CHEMISTRY FRONTIERS , 2022 , 9 (12) , 3247-3254 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
We herein describe a general approach to 5-trifluoromethyl 1,2,4-triazoles via the [3 + 2]-cycloaddition of nitrile imines generated in situ from hydrazonyl chloride with CF3CN, utilizing 2,2,2-trifluoroacetaldehyde O-(aryl)oxime as the precursor of trifluoroacetonitrile. Various functional groups, including alkyl-substituted hydrazonyl chloride, were tolerated during cycloaddition. Furthermore, the gram-scale synthesis and common downstream transformations proved the potential synthetic relevance of this developed methodology.
Keyword ：
cycloaddition cycloaddition nitrile imines nitrile imines triazole triazole trifluoroacetonitrile trifluoroacetonitrile trifluoromethyl trifluoromethyl
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lin, Bo , Zhang, Zipeng , Yao, Yunfei et al. Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3+2]-Cycloaddition of Nitrile Imines with CF3CN [J]. | MOLECULES , 2022 , 27 (19) . |
| MLA | Lin, Bo et al. "Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3+2]-Cycloaddition of Nitrile Imines with CF3CN" . | MOLECULES 27 . 19 (2022) . |
| APA | Lin, Bo , Zhang, Zipeng , Yao, Yunfei , You, Yi , Weng, Zhiqiang . Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3+2]-Cycloaddition of Nitrile Imines with CF3CN . | MOLECULES , 2022 , 27 (19) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A base promoted annulation of pyridinium ylides with trifluoroacetyl diazoester has been reported. Highly functionalized 4-trifluoromethyl pyridazines were synthesized in good yields without the use of any heavy metal catalysts. The developed methodology was compatible with a variety of important functional groups. Mechanistic studies revealed that trifluoroacetylated hydrazone was an active intermediate of this three-component annulation. Synthetic versatility of the method via aminolysis and condensation toward amide- and pyridazino[4,5-c]pyridazine-derivatives has been showcased.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Fang, Zheng , Teng, Yun , Yang, Huilin et al. Synthesis of 4-trifluoromethyl pyridazines via annulation of pyridinium ylides with trifluoroacetyl diazoester [J]. | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (17) : 3564-3569 . |
| MLA | Fang, Zheng et al. "Synthesis of 4-trifluoromethyl pyridazines via annulation of pyridinium ylides with trifluoroacetyl diazoester" . | ORGANIC & BIOMOLECULAR CHEMISTRY 20 . 17 (2022) : 3564-3569 . |
| APA | Fang, Zheng , Teng, Yun , Yang, Huilin , Li, Rongxing , Li, Qiuhong , You, Yi et al. Synthesis of 4-trifluoromethyl pyridazines via annulation of pyridinium ylides with trifluoroacetyl diazoester . | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (17) , 3564-3569 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Fluoroalkyl-containing organic compounds have exhibited wide applications in the field of pharmaceuticals, agrochemicals and materials science due to their outstanding properties such as biological activity, metabolic stability, lipophilicity, excellent chemical and thermal stability. Therefore, various synthetic strategies have been developed for the construction of fluoroalkyl-containing compounds, using highly active fluorinating reagents and fluorinated building blocks. Recently, the use of easily available and inexpensive trifluoroacetic anhydride (TFAA) and its anhydride analogues has attracted great attention to access numerous fluoroalkyl-containing compounds through cyclization and coupling reactions. In this review, we summarized the recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides as reagents. This review aims to provide a reference for researchers on how to develop new synthetic straregies of fluorine-containing organic compounds and achieve kilograms or even tons preparation of fluorine-containing organic compounds using fluoroalkyl anhydrides. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Coupling reaction Coupling reaction Cyclization reaction Cyclization reaction Fluoroalkanoyl Fluoroalkanoyl Fluoroalkl Fluoroalkl Fluoroalkyl anhydride Fluoroalkyl anhydride Fluoroalkyl-containing organic compound Fluoroalkyl-containing organic compound Trifluoroacetic anhydride (TFAA) Trifluoroacetic anhydride (TFAA)
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wu, Wei , You, Yi , Weng, Zhiqiang . Recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides [J]. | CHINESE CHEMICAL LETTERS , 2022 , 33 (10) : 4517-4530 . |
| MLA | Wu, Wei et al. "Recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides" . | CHINESE CHEMICAL LETTERS 33 . 10 (2022) : 4517-4530 . |
| APA | Wu, Wei , You, Yi , Weng, Zhiqiang . Recent advances in the synthesis of fluoroalkylated compounds using fluoroalkyl anhydrides . | CHINESE CHEMICAL LETTERS , 2022 , 33 (10) , 4517-4530 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
An aerobic copper-mediated domino reaction for the synthesis of 3-(trifluoromethylseleno)indoles by trifluoromethylselenolation of N-Ts 2-alkynylaniline with [(bpy)CuSeCF3](2) is reported. This reaction proceeds through sequential oxidation, alkyne coordination, and deprotonation followed by reductive elimination. This mild and robust method is highly functional group tolerant and provides straightforward access to 3-(trifluoromethylseleno)indoles in moderate to good yields.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wang, Hui , Yao, Yunfei , You, Yi et al. An aerobic copper-mediated domino process for the synthesis of 3-(trifluoromethylseleno)indoles [J]. | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (10) : 2115-2120 . |
| MLA | Wang, Hui et al. "An aerobic copper-mediated domino process for the synthesis of 3-(trifluoromethylseleno)indoles" . | ORGANIC & BIOMOLECULAR CHEMISTRY 20 . 10 (2022) : 2115-2120 . |
| APA | Wang, Hui , Yao, Yunfei , You, Yi , Huang, Yangjie , Weng, Zhiqiang . An aerobic copper-mediated domino process for the synthesis of 3-(trifluoromethylseleno)indoles . | ORGANIC & BIOMOLECULAR CHEMISTRY , 2022 , 20 (10) , 2115-2120 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A ring-expansion reaction of 2H-azirine with trifluoroacetic anhydride for the synthesis of 2-(trifluo-romethyl)oxazoles is disclosed. The reaction features readily available reactants, relatively mild condi-tions, and high yields of products. The generated 2-(trifluoromethyl)oxazole core could be easily converted into 3-(trifluoromethyl)-1,2,4-triazines through hydrazinolysis reaction.(c) 2022 Elsevier Ltd. All rights reserved.
Keyword ：
1 1 2 2 4-Triazine 4-Triazine Oxazole Oxazole Ring-expansion reaction Ring-expansion reaction Trifluoroacetic anhydride Trifluoroacetic anhydride Trifluoromethyl Trifluoromethyl
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Teng, Yun , Fang, Tingyu , Lin, Zitong et al. Ring-expansion reaction for the synthesis of 2-(trifluoromethyl)oxazoles and 3-(trifluoromethyl)-1,2,4-triazines [J]. | TETRAHEDRON LETTERS , 2022 , 107 . |
| MLA | Teng, Yun et al. "Ring-expansion reaction for the synthesis of 2-(trifluoromethyl)oxazoles and 3-(trifluoromethyl)-1,2,4-triazines" . | TETRAHEDRON LETTERS 107 (2022) . |
| APA | Teng, Yun , Fang, Tingyu , Lin, Zitong , Qin, Lu , Jiang, Mengfan , Wu, Wei et al. Ring-expansion reaction for the synthesis of 2-(trifluoromethyl)oxazoles and 3-(trifluoromethyl)-1,2,4-triazines . | TETRAHEDRON LETTERS , 2022 , 107 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
从命题思路、试题内容及特点和结果分析等3个方面对第11届全国大学生化学实验邀请赛的理论试题进行讨论分析和总结,同时对化学实验教学的改革提出几点思考和建议,以期促进高校化学实验教学的改革和创新.
Keyword ：
化学实验邀请赛 化学实验邀请赛 实验教学改革 实验教学改革 实验理论试题 实验理论试题
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | 郑琤 , 魏巧华 , 汤儆 et al. 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 [J]. | 化学教育 , 2021 , 42 (6) : 61-64 . |
| MLA | 郑琤 et al. "从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考" . | 化学教育 42 . 6 (2021) : 61-64 . |
| APA | 郑琤 , 魏巧华 , 汤儆 , 游毅 . 从化学实验竞赛探讨高校化学实验教学的改革和创新——第11届全国大学生化学实验邀请赛理论试题的解析与思考 . | 化学教育 , 2021 , 42 (6) , 61-64 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A novel synthesis approach for the construction of 2-trifluoroethyl-substituted benzofurans under copper-catalyzed conditions has been developed. The reaction of salicylaldehyde p-tosylhydrazones with 2-bromo-3,3,3-trifluoropropene proceeded through a sequential process to afford products in moderate to excellent yields (up to 93%). This method is also applicable to the formation of 2-trifluoroethylated indoles.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wu, Wei , Luo, Beibei , You, Yi et al. Copper-catalyzed one-pot synthesis of 2-(2,2,2-trifluoroethyl)-substituted benzofused heterocycles [J]. | ORGANIC CHEMISTRY FRONTIERS , 2021 , 8 (9) : 1997-2001 . |
| MLA | Wu, Wei et al. "Copper-catalyzed one-pot synthesis of 2-(2,2,2-trifluoroethyl)-substituted benzofused heterocycles" . | ORGANIC CHEMISTRY FRONTIERS 8 . 9 (2021) : 1997-2001 . |
| APA | Wu, Wei , Luo, Beibei , You, Yi , Weng, Zhiqiang . Copper-catalyzed one-pot synthesis of 2-(2,2,2-trifluoroethyl)-substituted benzofused heterocycles . | ORGANIC CHEMISTRY FRONTIERS , 2021 , 8 (9) , 1997-2001 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A method for the synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazole derivatives by the Lewis acid- and base-co-mediated reaction of perfluoroacetyl diazoester with ketones is reported. A series of structurally diverse 4-difluoromethylated and perfluoroalkylated pyrazoles were obtained in moderate to good yields. The reactions proceeded smoothly under mild conditions with wide functional group tolerance. (C) 2021 Elsevier Ltd. All rights reserved.
Keyword ：
Difluoromethyl Difluoromethyl Fluorine Fluorine Perfluoroalkyl Perfluoroalkyl Pyrazole Pyrazole
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Huahong , Wen, Shunli , Cui, Yubo et al. A method for synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazoles [J]. | TETRAHEDRON , 2021 , 85 . |
| MLA | Chen, Huahong et al. "A method for synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazoles" . | TETRAHEDRON 85 (2021) . |
| APA | Chen, Huahong , Wen, Shunli , Cui, Yubo , Lin, Lu , Zhang, Hanbang , Fang, Zheng et al. A method for synthesis of polysubstituted 4-difluoromethyl and perfluoroalkyl pyrazoles . | TETRAHEDRON , 2021 , 85 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
