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学者姓名：石贤爱
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| GB/T 7714 | Yang, Jianmin , Cai, Fengying , Lv, Yicheng et al. Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024) [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
| MLA | Yang, Jianmin et al. "Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024)" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 297 (2025) . |
| APA | Yang, Jianmin , Cai, Fengying , Lv, Yicheng , Jiang, Ting , Zhao, Xingkai , Hu, Xueli et al. Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds (vol 257, 128561, 2024) . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2025 , 297 . |
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Resveratrol (Res) is a natural polyphenol exhibiting anti-oxidant and anti-inflammatory activity. However, the applications of Res have been limited due to its low stability and water solubility. To enhance the bioaccessibility of Res, unfolding bovine serum albumin-modified selenium nanoparticles (UBSA@SeNPs) encapsulated within chitosan (CS)-coated Pickering emulsions (CS-UBSA@SeNPs-PE) were used to load Res. The results showed that Res-loaded CS(0.06 %)-UBSA@SeNPs-PE has small droplet size (16.13 μm), high gel properties and excellent antioxidant properties. During the simulated digestion process, CS reduced the release rate of Res from Res-loaded CS(0.06 %)-UBSA@SeNPs-PE (42.27 %) to reach a slow release effect. Importantly, Res could quickly release from CS-UBSA@SeNPs-PE within intestinal fluid or in the presence of chitosanase. In simulated absorption experiments, the intestinal permeability of Res in Res-loaded CS(0.06 %)-UBSA@SeNPs-PE were enhanced by 292.31 % compare to Res-loaded CS(0 %)-UBSA@SeNPs-PE. In pharmacokinetic studies, Res-loaded CS(0.06 %)-UBSA@SeNPs-PE had an area under the curve (AUC) up to 3467.99 ± 127.43 ng*h/mL. Furthermore, CS also improved the mucoadhesive nature of UBSA@SeNPs-PE, resulting in a gut-retention time of Res-loaded CS(0.06 %)-UBSA@SeNPs-PE that reached up to 60 h. In conclusion, CS-UBSA@SeNPs-PE can serve as an effective oral delivery system for improving the bioaccessibility of Res. © 2024 Elsevier B.V.
Keyword ：
Body fluids Body fluids Chitosan Chitosan Crosslinking Crosslinking Gels Gels Silicones Silicones Surface plasmon resonance Surface plasmon resonance
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| GB/T 7714 | Mei, Jingtao , Shi, Xianai , Chen, Mingmao et al. Unfolding bovine serum albumin decorated selenium nanoparticles crosslinking with chitosan: Achieve stabilization of Pickering emulsions gel and enhance resveratrol bioaccessibility [J]. | International Journal of Biological Macromolecules , 2025 , 289 . |
| MLA | Mei, Jingtao et al. "Unfolding bovine serum albumin decorated selenium nanoparticles crosslinking with chitosan: Achieve stabilization of Pickering emulsions gel and enhance resveratrol bioaccessibility" . | International Journal of Biological Macromolecules 289 (2025) . |
| APA | Mei, Jingtao , Shi, Xianai , Chen, Mingmao , Cui, Yanan , Fang, Chaoping , Yang, Licong . Unfolding bovine serum albumin decorated selenium nanoparticles crosslinking with chitosan: Achieve stabilization of Pickering emulsions gel and enhance resveratrol bioaccessibility . | International Journal of Biological Macromolecules , 2025 , 289 . |
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The effective repair of large bone defects remains a major challenge due to its limited self-healing capacity. Inspired by the structure and function of the natural periosteum, an electrospun biomimetic periosteum is constructed to programmatically promote bone regeneration using natural bone healing mechanisms. The biomimetic periosteum is composed of a bilayer with an asymmetric structure in which an aligned electrospun poly(epsilon-caprolactone)/gelatin/deferoxamine (PCL/GEL/DFO) layer mimics the outer fibrous layer of the periosteum, while a random coaxial electrospun PCL/GEL/aspirin (ASP) shell and PCL/silicon nanoparticles (SiNPs) core layer mimics the inner cambial layer. The bilayer controls the release of ASP, DFO, and SiNPs to precisely regulate the inflammatory, angiogenic, and osteogenic phases of bone repair. The random coaxial inner layer can effectively antioxidize, promoting cell recruitment, proliferation, differentiation, and mineralization, while the aligned outer layer can promote angiogenesis and prevent fibroblast infiltration. In particular, different stages of bone repair are modulated in a rat skull defect model to achieve faster and better bone regeneration. The proposed biomimetic periosteum is expected to be a promising candidate for bone defect healing. An electrospun biomimetic periosteum with an asymmetric structure is prepared through aligned and coaxial electrospinning for programed promotion of bone regeneration. This biomimetic periosteum exhibits controlled release of multiple agents, enabling regulation of the inflammatory, angiogenic, and osteogenic phases that are essential for bone healing. It demonstrates good efficacy in promoting bone regeneration in a rat skull defect model. image
Keyword ：
asymmetric structure asymmetric structure biomimetic periosteum biomimetic periosteum bone defect bone defect electrospinning electrospinning programmed repair programmed repair
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| GB/T 7714 | Zhao, Xingkai , Zhuang, Yu , Cao, Yongjian et al. Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (12) . |
| MLA | Zhao, Xingkai et al. "Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration" . | ADVANCED HEALTHCARE MATERIALS 13 . 12 (2024) . |
| APA | Zhao, Xingkai , Zhuang, Yu , Cao, Yongjian , Cai, Fengying , Lv, Yicheng , Zheng, Yunquan et al. Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (12) . |
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The redox homeostasis defense mechanism of tumor cells is one of the prime reasons for the unsatisfactory effect of photodynamic therapy (PDT). So far, little attention has been paid to this obstacle. In this work, we reported a synthesizing simple yet versatile nanogel (BCPS), synthesized by cystamine dihydrochloride functionalized sodium carboxymethylcellulose (CMC-SS), bovine serum albumin, and Phycocyanobilin self-assembly. The BCPS reduced the levels of glutathione molecules by reacting with glutathione, thereby interfering with intracellular redox homeostasis and enhancing the sensitivity of tumor cells to PDT. The BCPS was shown to possess excellent serum stability, high blood compatibility, low toxic side effects, and higher reactive oxygen species (ROS) utilization. After irradiation, the BCPS could significantly increase intracellular ROS level by approximately 1.6-fold and decrease the IC50 to HeLa cells by approximately 1.5-fold, compared to the pre-functional drugs BCP. This proposed strategy, based on increasing the utilization rate of ROS in tumor cells is promising for application potentials in tumor therapy.
Keyword ：
Green self-assembly Green self-assembly Long-circulating Long-circulating Photodynamic therapy Photodynamic therapy Redox-responsive Redox-responsive Tumor-targeted drug delivery Tumor-targeted drug delivery
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| GB/T 7714 | Liao, Wenqiang , Xiao, Siqi , Yang, Jianmin et al. Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy [J]. | CARBOHYDRATE POLYMERS , 2024 , 323 . |
| MLA | Liao, Wenqiang et al. "Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy" . | CARBOHYDRATE POLYMERS 323 (2024) . |
| APA | Liao, Wenqiang , Xiao, Siqi , Yang, Jianmin , Shi, Xianai , Zheng, Yunquan . Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy . | CARBOHYDRATE POLYMERS , 2024 , 323 . |
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The management of severe full-thickness skin defect wounds remains a challenge due to their irregular shape, uncontrollable bleeding, high risk of infection, and prolonged healing period. Herein, an all-in-one OD/GM/QCS@Exo hydrogel was prepared with catechol-modified oxidized hyaluronic acid (OD), methylacrylylated gelatin (GM), and quaternized chitosan (QCS) and loaded with adipose mesenchymal stem cell-derived exosomes (Exos). Cross-linking of the hydrogel was achieved using visible light instead of ultraviolet light irradiation, providing injectability and good biocompatibility. Notably, the incorporation of catechol groups and multicross-linked networks in the hydrogels conferred strong adhesion properties and mechanical strength against external forces such as tensile and compressive stress. Furthermore, our hydrogel exhibited antibacterial, anti-inflammatory, and antioxidant properties along with wound-healing promotion effects. Our results demonstrated that the hydrogel-mediated release of Exos significantly promotes cellular proliferation, migration, and angiogenesis, thereby accelerating skin structure reconstruction and functional recovery during the wound-healing process. Overall, the all-in-one OD/GM/QCS@Exo hydrogel provided a promising therapeutic strategy for the treatment of full-thickness skin defect wounds through actively participating in the entire process of wound healing.
Keyword ：
all-in-one all-in-one exosomes exosomes multifunctionalhydrogel multifunctionalhydrogel quaternized chitosan quaternized chitosan visible light cross-linkable visible light cross-linkable
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| GB/T 7714 | Lv, Yicheng , Li, Liang , Zhang, Jingyuan et al. Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (20) : 25923-25937 . |
| MLA | Lv, Yicheng et al. "Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process" . | ACS APPLIED MATERIALS & INTERFACES 16 . 20 (2024) : 25923-25937 . |
| APA | Lv, Yicheng , Li, Liang , Zhang, Jingyuan , Li, Jingsi , Cai, Fengying , Huang, Yufeng et al. Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (20) , 25923-25937 . |
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Currently, cisplatin resistance has been recognized as a multistep cascade process for its clinical chemotherapy failure. Hitherto, it remains challenging to develop a feasible and promising strategy to overcome the cascade drug resistance (CDR) issue for achieving fundamentally improved chemotherapeutic efficacy. Herein, a novel self-assembled nanoagent is proposed, which is constructed by Pt(IV) prodrug, cyanine dye (cypate), and gadolinium ion (Gd3+), for systematically conquering the cisplatin resistance by employing near-infrared (NIR) light activated mild-temperature hyperthermia in tumor targets. The proposed nanoagents exhibit high photostability, GSH/H+-responsive dissociation, preferable photothermal conversion, and enhanced cellular uptake performance. In particular, upon 785-nm NIR light irradiation, the generated mild temperature of approximate to 43 degrees C overtly improves the cell membrane permeability and drug uptake, accelerates the disruption of intracellular redox balance, and apparently enhances the formation of Pt-DNA adducts, thereby effectively overcoming the CDR issue and achieves highly improved therapeutic efficacy for cisplatin-resistant tumor ablation. A novel self-assembled nanoagent (Cy-Pt@HA NP) is developed to conquer the cascade drug resistance (CDR) issue of cisplatin. The proposed nanoagent presents NIR light-triggered mild hyperthermia, superior cellular uptake, and tumor-microenvironment-responsive dissociation for effective ablation of drug-resistant tumors, thereby opening a new avenue for addressing CDR issue and maximizing the platinum-based therapeutic efficacy for cancer treatment.image
Keyword ：
cascade cisplatin resistance cascade cisplatin resistance coordination self-assembly coordination self-assembly improved synergistic therapy improved synergistic therapy mild-temperature hyperthermia mild-temperature hyperthermia NIR light-responsive NIR light-responsive
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| GB/T 7714 | Chen, Mingmao , Fu, Yulei , Liu, Yan et al. NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
| MLA | Chen, Mingmao et al. "NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy" . | ADVANCED HEALTHCARE MATERIALS 13 . 11 (2024) . |
| APA | Chen, Mingmao , Fu, Yulei , Liu, Yan , Zhang, Baihe , Song, Xiaorong , Chen, Xinchun et al. NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (11) . |
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Abdominal and intrauterine adhesions are common postoperative problems that can cause serious complications. Current adhesives are usually double sided and suffer from poor wet adhesion, nondegradability, and monofunctionality, which limits their application in preventing postoperative adhesions. Herein, a bioinspired microstructured Janus bioadhesive, named OD/GM@PG, with a wet adhesive inner layer and an antiadhesive outer layer is prepared by combining electrostatic spun and adhesive materials. By using both capillary suction and a catechol-based strategy, the wet adhesive strength and interfacial toughness of the Janus bioadhesive reach 98 kPa and 325 J m-2, respectively, which are much higher than those of commercial fibrin glues and cyanoacrylate glues. The electrostatic spun outer layer acts as a physical barrier with antiadhesive and friction-reducing effects. Additionally, the Janus bioadhesive demonstrates biodegradable, hemostatic, antioxidative, anti-inflammatory, and prohealing properties. In vivo results show that the asymmetric adhesion effect of the Janus bioadhesive effectively preventing postoperative abdominal and intrauterine adhesions. Notably, tandem mass tags-labeled quantitative proteomics analysis demonstrate that the expression of inflammatory response-associated proteins (S100A8, S100A9) is associated with adhesion; the Janus bioadhesive significantly downregulates this expression. Therefore, the OD/GM@PG Janus bioadhesive is a promising candidate for preventing postoperative adhesions. A bioinspired microstructured Janus bioadhesive with an asymmetric structure and adhesion behavior is prepared by combining electrostatic spinning and adhesive materials. By employing capillary suction and a catechol-based strategy, the Janus bioadhesive exhibits impressive wet adhesive strength and interfacial toughness. Furthermore, the asymmetric adhesion effect of the Janus bioadhesive effectively alleviates postoperative abdominal and intrauterine adhesions. image
Keyword ：
capillary suction capillary suction fertility restoration fertility restoration Janus bioadhesive Janus bioadhesive preventing postoperative adhesion preventing postoperative adhesion wet adhesion wet adhesion
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| GB/T 7714 | Lv, Yicheng , Cai, Fengying , Zhao, Xingkai et al. Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (21) . |
| MLA | Lv, Yicheng et al. "Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions" . | ADVANCED FUNCTIONAL MATERIALS 34 . 21 (2024) . |
| APA | Lv, Yicheng , Cai, Fengying , Zhao, Xingkai , Zhu, Xintao , Wei, Fanan , Zheng, Yunquan et al. Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (21) . |
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Platelet-rich plasma (PRP) has become an important regenerative therapy. However, the preparation method of PRP has not been standardized, and the optimal platelet concentration for PRP used in skin wound repair is unclear, leading to inconsistent clinical efficacy of PRP. Therefore, the development of standardized preparation methods for PRP and the investigation of the dose-response relationship between PRP with different platelet concentrations and tissue regeneration plays an important role in the development and clinical application of PRP technology. This study has developed an integrated blood collection device from blood drawing to centrifugation. Response surface methodology was employed to optimize the preparation conditions, ultimately achieving a platelet recovery rate as high as 95.74% for PRP (with optimal parameters: centrifugation force 1730x g, centrifugation time 10 min, and serum separation gel dosage 1.4 g). Both in vitro and in vivo experimental results indicate that PRP with a (2x) enrichment ratio is the most effective in promoting fibroblast proliferation and skin wound healing, with a cell proliferation rate of over 150% and a wound healing rate of 78% on day 7.
Keyword ：
high recovery rate high recovery rate optimal preparation method optimal preparation method platelet-poor plasma platelet-poor plasma platelet-rich plasma platelet-rich plasma skin restoration skin restoration
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| GB/T 7714 | Qiu, Mengjie , He, Yating , Zhang, Haijie et al. Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024 , 25 (17) . |
| MLA | Qiu, Mengjie et al. "Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25 . 17 (2024) . |
| APA | Qiu, Mengjie , He, Yating , Zhang, Haijie , Zheng, Yunquan , Shi, Xianai , Yang, Jianmin . Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2024 , 25 (17) . |
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Cell surface engineering technologies can regulate cell function and behavior by modifying the cell surface. Previous studies have mainly focused on investigating the effects of cell surface engineering reactions and materials on cell activity. However, they do not comprehensively analyze other cellular processes. This study exploits covalent bonding, hydrophobic interactions, and electrostatic interactions to modify the macromolecules succinimide ester-methoxy polyethylene glycol (NHS-mPEG), distearoyl phosphoethanolamine-methoxy polyethylene glycol (DSPE-mPEG), and poly-L-lysine (PLL), respectively, on the cell surface. This work systematically investigates the effects of the three surface engineering reactions on the behavior of human umbilical vein endothelial cells (HUVECs) and human skin fibroblasts, including viability, growth, proliferation, cell cycle, adhesion, and migration. The results reveals that the PLL modification method notably affects cell viability and G2/M arrest and has a short modification duration. However, the DSPE-mPEG and NHS-mPEG modification methods have little effect on cell viability and proliferation but have a prolonged modification duration. Moreover, the DSPE-mPEG modification method highly affects cell adherence. Further, the NHS-mPEG modification method can significantly improve the migration ability of HUVECs by reducing the area of focal adhesions. The findings of this study will contribute to the application of cell surface engineering technology in the biomedical field.
Keyword ：
cell biological behavior cell biological behavior cell surface engineering cell surface engineering covalent bonding covalent bonding electrostatic interaction electrostatic interaction hydrophobic interaction hydrophobic interaction
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| GB/T 7714 | Cai, Fengying , Ren, Yafeng , Dai, Jiajia et al. Effects of Various Cell Surface Engineering Reactions on the Biological Behavior of Mammalian Cells [J]. | MACROMOLECULAR BIOSCIENCE , 2023 , 23 (3) . |
| MLA | Cai, Fengying et al. "Effects of Various Cell Surface Engineering Reactions on the Biological Behavior of Mammalian Cells" . | MACROMOLECULAR BIOSCIENCE 23 . 3 (2023) . |
| APA | Cai, Fengying , Ren, Yafeng , Dai, Jiajia , Yang, Jianmin , Shi, Xianai . Effects of Various Cell Surface Engineering Reactions on the Biological Behavior of Mammalian Cells . | MACROMOLECULAR BIOSCIENCE , 2023 , 23 (3) . |
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The complexity of genetic circuits has not seen a significant increase over the last decades, even with the rapid development of synthetic biology tools. One of the bottlenecks is the limited number of orthogonal transcription factor-operator pairs. Researchers have tried to use aptamer-ligand pairs as genetic parts to regulate transcription. However, most aptamers selected using traditional methods cannot be directly applied in gene circuits for transcriptional regulation. To that end, we report a new method called CIVT-SELEX to select DNA aptamers that can not only bind to macromolecule ligands but also undergo significant conformational changes, thus affecting transcription. The single-stranded DNA library with affinity to our example ligand human thrombin protein is first selected and enriched. Then, these ssDNAs are inserted into a genetic circuit and tested in the in vitro transcription screening to obtain the ones with significant inhibitory effects on downstream gene transcription when thrombins are present. These aptamer-thrombin pairs can inhibit the transcription of downstream genes, demonstrating the feasibility and robustness of their use as genetic parts in both linear DNAs and plasmids. We believe that this method can be applied to select aptamers of any target ligands and vastly expand the genetic part library for transcriptional regulation.
Keyword ：
aptamer aptamer CIVT-SELEX CIVT-SELEX genetic part genetic part synthetic biology synthetic biology thrombin thrombin transcriptional regulation transcriptional regulation
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| GB/T 7714 | Guo, Shaobin , Xu, Zeqi , Lin, Lujie et al. Using CIVT-SELEX to Select Aptamers as Genetic Parts to Regulate Gene Circuits in a Cell-Free System [J]. | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (3) . |
| MLA | Guo, Shaobin et al. "Using CIVT-SELEX to Select Aptamers as Genetic Parts to Regulate Gene Circuits in a Cell-Free System" . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 . 3 (2023) . |
| APA | Guo, Shaobin , Xu, Zeqi , Lin, Lujie , Guo, Yan , Li, Jingying , Lu, Chunhua et al. Using CIVT-SELEX to Select Aptamers as Genetic Parts to Regulate Gene Circuits in a Cell-Free System . | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , 2023 , 24 (3) . |
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