Query：
学者姓名：林翠英
Refining：
Year
Type
Indexed by
Source
Complex
Former Name
Co-
Language
Clean All
Abstract ：
In this study, we present the innovative design and comprehensive evaluation of a novel point-of-care testing (POCT) methodology for the rapid and accurate detection of T-2 toxin, a potent mycotoxin with significant implications for food safety and human health. The cornerstone of this approach lies in the integration of a copper-based conductive metal-organic framework (Cu3(HHTP)2) with a target-responsive DNA hydrogel system, creating a dual-signal readout mechanism that significantly enhances detection sensitivity and specificity. Specifically, the hydrogel covers the material's surface metal active sites, which become exposed upon target addition due to hydrogel collapse. The released Cu3(HHTP)2 can catalyze the oxidation of 3,3 ',5,5 '-tetrame-thylbenzidine, resulting in a colorimetric and temperature change in the solution. This dual-mode detection strategy enables both qualitative assessment through direct visual inspection of color change and quantitative analysis by monitoring the solution temperature variation post laser irradiation with a thermometer. Under the optimized conditions, the detection system demonstrates a wide range spanning from 5 to 200 ng/mL, with a detection limit of 1.67 ng/mL. This method has been successfully demonstrated through the analysis of real-world samples, yielding encouraging results that underscore its reliability and effectiveness. The proposed dual-signal approach boasts advantages such as straightforward operational procedures, unambiguous signal outputs, and robust practicality, making it an attractive option for mycotoxin detection in resource-constrained settings and developing regions.
Keyword ：
Cu3(HHTP)2 Cu3(HHTP)2 Point-of-care testing Point-of-care testing T-2 toxin T-2 toxin Target-responsive DNA hydrogel Target-responsive DNA hydrogel
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lin, Jiarong , Deng, Ye , Lin, Yue et al. Advanced dual-signal point-of-care testing platform for sensitive T-2 toxin detection: Integrating copper-based conductive MOF with target-responsive DNA hydrogel [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 438 . |
| MLA | Lin, Jiarong et al. "Advanced dual-signal point-of-care testing platform for sensitive T-2 toxin detection: Integrating copper-based conductive MOF with target-responsive DNA hydrogel" . | SENSORS AND ACTUATORS B-CHEMICAL 438 (2025) . |
| APA | Lin, Jiarong , Deng, Ye , Lin, Yue , Luo, Fang , Weng, Zuquan , Wang, Jian et al. Advanced dual-signal point-of-care testing platform for sensitive T-2 toxin detection: Integrating copper-based conductive MOF with target-responsive DNA hydrogel . | SENSORS AND ACTUATORS B-CHEMICAL , 2025 , 438 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Filling the microchannel with negatively charged hydrogel can exhibit microsacle ion current rectification (ICR) behavior, which is attributed to the space negative charge and structural asymmetry of hydrogel. In this study, this character had been applied to develop a trypsin sensor for the first time. A hydrogel synthesized with bovine serum albumin (BSA) and glyoxal (BSAG hydrogel) was filled at the tip of microchannel firstly. Subsequently, the BSAG hydrogel-filled microchannel was immersed in a trypsin solution to hydrolyze the BSA within the BSAG hydrogel. This process changes the space charge density and pore size of the BSAG hydrogel-filled microchannel, leading to a change in microscale ICR, which can be used for quantifying trypsin. Then the key parameters affecting the sensing performance such as the concentration of BSA, strength of the electrolyte, pH and reaction time were optimized. The detection range was from 10.0 ng/mL to 100 mu g/mL with a detection limit as low as 2.55 ng/mL (S/N = 3). Due to the distinctive three-dimensional pore structure of the hydrogel and the specificity of trypsin for BSA hydrolysis, the sensor exhibits high sensitivity and specificity, as well as remarkable reproducibility and stability. This sensor has been effectively used to measure trypsin levels in human serum samples.
Keyword ：
Hydrogel Hydrogel Microchannel Microchannel Microscale ionic current rectification Microscale ionic current rectification Space negtive charge Space negtive charge Trypsin Trypsin
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Cai, Huabin , Yuan, Runhao , Huang, Shaokun et al. Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel [J]. | TALANTA , 2025 , 285 . |
| MLA | Cai, Huabin et al. "Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel" . | TALANTA 285 (2025) . |
| APA | Cai, Huabin , Yuan, Runhao , Huang, Shaokun , Huang, Yanling , Lin, Cuiying , Lin, Yue et al. Sensitive trypsin sensor based on the regulation of microscale ionic current rectification by the selectivity hydrolysis of hydrogel filled in microchannel . | TALANTA , 2025 , 285 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
A highly efficient and sensitive non-enzymatic glucose sensor fabricated using NiO/NiPc composite nanomaterials was introduced by this study. The sensor employed a unique design by modifying the ITO electrode with the NiO/NiPc heterojunction. This enhancement was achieved by improving charge separation and transfer through the type-II heterojunction formed between NiO and NiPc. The integration of NiO/NiPc composite materials also improved the electrocatalytic activity. This enhancement was attributed to the increased concentration of oxygen vacancies, thereby boosting the overall performance of the sensor. The results of the sensor application demonstrated that under the optimized conditions (pH 4.0, -0.3 V bias), the sensor exhibited remarkable sensitivity and selectivity towards glucose, with a linear relationship between the photocurrent change and glucose concentration. The detection limit was as low as 0.016 nM, and the sensitivity was 4.146 mu A & sdot;mM- 1 & sdot;cm- 2. The sensor demonstrated excellent repeatability, stability, and high recovery rate in real sweat sample testing, highlighting its great potential for practical glucose detection applications.
Keyword ：
Glucose Glucose NiO NiO NiPc NiPc Photoelectrochemical sensor Photoelectrochemical sensor
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Xue, Xiaoyan , Wu, Wenru , Yang, Yating et al. Oxygen vacancy-enriched NiO/NiPc heterojunction for highly efficient and sensitive non-enzymatic glucose sensing [J]. | MICROCHEMICAL JOURNAL , 2025 , 208 . |
| MLA | Xue, Xiaoyan et al. "Oxygen vacancy-enriched NiO/NiPc heterojunction for highly efficient and sensitive non-enzymatic glucose sensing" . | MICROCHEMICAL JOURNAL 208 (2025) . |
| APA | Xue, Xiaoyan , Wu, Wenru , Yang, Yating , Lin, Yue , Luo, Fang , Lin, Cuiying et al. Oxygen vacancy-enriched NiO/NiPc heterojunction for highly efficient and sensitive non-enzymatic glucose sensing . | MICROCHEMICAL JOURNAL , 2025 , 208 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The persistence of T-2 toxin in food and feed matrices renders it a pervasive contaminant, impacting both human and animal health. Traditional detection methods suffer from cumbersome instrumentation and intricate procedures, rendering on-site detection of T-2 toxin unfeasible. Therefore, we have constructed a real-time detection method for T-2 toxin detection by employing a target-responsive DNA hydrogel in conjunction with potassium iodide starch test paper. This method integrates both colorimetric and distance-based signal outputs, offering a streamlined and effective approach for the on-site detection of T-2 toxin. The specific binding of the target to the aptamer in the DNA hydrogel results in the collapse of the hydrogels structure, which changes the viscosity of the system and released horseradish peroxidase in the hydrogel wrapped, and then produces blue-purple marks of different lengths on the starch iodide papers to achieve the specific detection of T-2 toxin. Under optimized conditions, the assay exhibits a detection range spanning from 10 ng/mL to 10 mg/mL for the toxin, with a detection limit of 12.83 ng/mL. The proposed method has been successfully applied for the detection of real corn samples with satisfied result. Such colorimetric-distance dual signal detection method offers notable advantages, including straightforward operation, clear signal interpretation, and practical utility. Its implementation enables rapid, on-the-spot detection of T-2 toxin, particularly beneficial in resource-limited regions and less developed countries.
Keyword ：
Point-of-care testing Point-of-care testing Starch iodide paper Starch iodide paper T-2 toxin T-2 toxin Target-responsive DNA hydrogel Target-responsive DNA hydrogel
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Deng, Ye , Lin, Jiarong , Wang, Jingxuan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper [J]. | MICROCHEMICAL JOURNAL , 2025 , 210 . |
| MLA | Deng, Ye et al. "Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper" . | MICROCHEMICAL JOURNAL 210 (2025) . |
| APA | Deng, Ye , Lin, Jiarong , Wang, Jingxuan , Lin, Yue , Luo, Fang , Weng, Zuquan et al. Dual-signal point-of-care testing method for T-2 toxin utilizing target-responsive DNA hydrogel and starch iodide paper . | MICROCHEMICAL JOURNAL , 2025 , 210 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Combined the electrostatic interaction of the negatively charged gold nanorods (AuNRs) (as acceptor) and Ru(bpy)(3)(2+) (as donor), an electrochemiluminescence resonance energy transfer (ECL-RET) sensor was constructed and applied for the detection of organophosphorus pesticides (OPs). Negatively charged AuNRs were synthesized by modifying AuNRs with polystyrene sulfonate (PSS) firstly, which can bind to Ru(bpy)(3)(2+) through electrostatic interaction so that the luminophore was absorbed by the acceptor, the resonance energy transfer occurred and only low ECL signal had been detected. Thiocholine can be produced by the hydrolysis process of acetylthiocholine (ATCh) with the help of acetylcholinesterase (AChE), which can bond with PSS-modified AuNRs (PSS-AuNRs) through gold-sulfur interaction, this caused the releasing of the adsorbed Ru(bpy)(3)(2+) into the solution and resulting in the restoration of the ECL intensity. However, the activity of AChE was inhibited by OPs, and the recovery process of the ECL signal was thus suppressed as well. In this study, chlorpyrifos was chosen as model target, the results indicated that the correlation between the ECL intensity and the logarithm of chlorpyrifos concentration showed remarkable linearity across 1 ng/mL to 1 mg/mL, achieving a detection limit of 0.51 ng/mL. The proposed system has been utilized for detecting OPs in real samples with satisfied results.
Keyword ：
Acetylcholinesterase Acetylcholinesterase Electrochemiluminescence Electrochemiluminescence Gold nanorods Gold nanorods Organophosphorus pesticides Organophosphorus pesticides Resonance energy transfer Resonance energy transfer
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, Zixin , Lin, Zeyu , Chen, Lifen et al. Electrochemiluminescence sensor for organophosphorus pesticides based on the regulation of resonance energy transfer between negative charged gold nanorods and Ru(bpy)32+ [J]. | TALANTA , 2025 , 281 . |
| MLA | Li, Zixin et al. "Electrochemiluminescence sensor for organophosphorus pesticides based on the regulation of resonance energy transfer between negative charged gold nanorods and Ru(bpy)32+" . | TALANTA 281 (2025) . |
| APA | Li, Zixin , Lin, Zeyu , Chen, Lifen , Lin, Yue , Luo, Fang , Lin, Cuiying et al. Electrochemiluminescence sensor for organophosphorus pesticides based on the regulation of resonance energy transfer between negative charged gold nanorods and Ru(bpy)32+ . | TALANTA , 2025 , 281 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Changes in the charge density on the inner surface of the microchannel can modulate the ion concentration at the tip, thus causing changes in the resistance of the system. In this study, this property is adopted to construct a portable sensor using a multimeter and aflatoxin B1 (AFB1) is used as the model target. Initially, the cDNA/aptamer complex is modified in the microchannel. The inner microchannel surface's charge density is then altered by the recognition of the target, leading to a change in the system's resistance, which can be conveniently monitored using a multimeter. Critical parameters influencing the performance of the system are optimized. Under optimum conditions, the resistance is linearly related to the logarithm of AFB1 concentration in the range of 100 fM-10 nM and the detection limit is 46 fM (S/N = 3). The resistive measurement is separated from the recognition reaction of the target, reducing the matrix interference during the detection process. This sensor boasts high sensitivity and specificity coupled with commendable reproducibility and stability. It is applied to assay the AFB1 content successfully in an actual sample of corn. Moreover, this approach is cost-effective, user-friendly, and highly accurate.
Keyword ：
aflatoxin B1 aflatoxin B1 microchannel microchannel portablesensor portablesensor resistance resistance surface charge density surface charge density
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Cai, Huabin , Huang, Yanling , Lin, Yue et al. Portable Sensor for Aflatoxin B1 Based on the Regulation of Resistance of a Microchannel Using a Multimeter as Readout [J]. | ACS SENSORS , 2024 , 9 (1) : 494-501 . |
| MLA | Cai, Huabin et al. "Portable Sensor for Aflatoxin B1 Based on the Regulation of Resistance of a Microchannel Using a Multimeter as Readout" . | ACS SENSORS 9 . 1 (2024) : 494-501 . |
| APA | Cai, Huabin , Huang, Yanling , Lin, Yue , Luo, Fang , Chen, Lifen , Guo, Longhua et al. Portable Sensor for Aflatoxin B1 Based on the Regulation of Resistance of a Microchannel Using a Multimeter as Readout . | ACS SENSORS , 2024 , 9 (1) , 494-501 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The control of nanoparticle morphology can effectively change their properties. Adjusting the aggregation state of bovine serum albumin-coated gold nanoclusters (BSA-Au NCs) can regulate the enzyme-mimicking catalytic activity. Hyaluronic acid (HA) induces the aggregation of BSA-Au NCs, leading to the shielding of the catalytic active sites and a decrease in activity; this feature has been utilized to design a multicolor biosensor for hyaluronidase (HAase). The presence of HAase can hydrolyze the glycosidic bonds in HA, causing the aggregated BSA-Au NCs to disperse and express their catalytic activity, which in turn catalyzes the etching of Au nanobipyramids (Au-NBPs) in the presence of 3,3 ',5,5 ' -tetramethylbenzidine (TMB), resulting in a morphological transition from bipyramidal to ellipsoidal and spherical shapes, while the solution displays a variety of colors. Visual recognition of these multicolor changes establishes a relationship between the enzyme activity and color. Based on the controlled aggregation and dispersion of BSA-Au NCs and the etching of Au-NBPs, a simple multicolor HAase biosensor was designed. The proposed biosensor shows a linear response to HAase concentrations in the range of 5-80 U/mL, with clear color changes under optimized conditions. The limit of detection (LOD) of the sensor was determined to be 1.98 U/mL (LOD = 3s/k). This method successfully applies the changing of enzyme-mimicking catalytic activity nanoparticles for colorimetric analysis detection.
Keyword ：
aggregation statemodulation aggregation statemodulation Au nanocluster Au nanocluster hyaluronidase hyaluronidase multicolor multicolor nanozymes nanozymes
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Tian, Mengjian , Lin, Cuiying , Lin, Yue et al. Multicolor Biosensor of Hyaluronidase by the Regulation of Enzyme-Like Catalytic Activity of Au Nanoclusters through Changes in the Aggregation State [J]. | ACS APPLIED NANO MATERIALS , 2024 , 7 (5) : 5620-5627 . |
| MLA | Tian, Mengjian et al. "Multicolor Biosensor of Hyaluronidase by the Regulation of Enzyme-Like Catalytic Activity of Au Nanoclusters through Changes in the Aggregation State" . | ACS APPLIED NANO MATERIALS 7 . 5 (2024) : 5620-5627 . |
| APA | Tian, Mengjian , Lin, Cuiying , Lin, Yue , Luo, Fang , Qiu, Bin , Wang, Jian et al. Multicolor Biosensor of Hyaluronidase by the Regulation of Enzyme-Like Catalytic Activity of Au Nanoclusters through Changes in the Aggregation State . | ACS APPLIED NANO MATERIALS , 2024 , 7 (5) , 5620-5627 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The electrochemiluminescence (ECL) intensity can be regulated by ionic current passing through the microchannel, which broadened the regulation of the ECL sensors. But in the early reported sensors, the electrostatic repulsion and steric hindrance caused few targets to approach the interface of the microchannel driven by concentration difference, which reduced the detection efficiency and prolonged the detection period. In this study, different accumulation strategies, such as a positive electric field and different polarity electric fields, were designed to accumulate targets in the microchannel. The interaction of azide groups and hydrogen sulfide served as a research model. Hydrogen sulfide can react with the negatively charged azide groups in the microchannel surface to produce positively charged amino groups, decreasing the negative charge density of the microchannel and thus altering the ionic current and ECL intensity. The accumulation of hydrogen sulfide at the microchannel tip can increase the collision probability with azide groups to improve the detection efficiency, and the integration of accumulation and reaction can shorten the detection period to 28 min. The hydrogen sulfide concentration on the microchannel tip accumulated by applying different polarity electric fields was 22.3-fold higher than that accumulated by applying a positive electric field. The selected research model broadened the application range of a microchannel-based ECL sensor and confirmed the universality of the microchannel-based ECL sensor.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Huang, Yanling , Cai, Huabin , Lin, Yue et al. Charge Density-Regulated Microchannel-Based Electrochemiluminescence Sensor for Hydrogen Sulfide Detection with a Highly Efficient Accumulation Strategy [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (13) : 5251-5257 . |
| MLA | Huang, Yanling et al. "Charge Density-Regulated Microchannel-Based Electrochemiluminescence Sensor for Hydrogen Sulfide Detection with a Highly Efficient Accumulation Strategy" . | ANALYTICAL CHEMISTRY 96 . 13 (2024) : 5251-5257 . |
| APA | Huang, Yanling , Cai, Huabin , Lin, Yue , Luo, Fang , Lin, Cuiying , Wang, Jian et al. Charge Density-Regulated Microchannel-Based Electrochemiluminescence Sensor for Hydrogen Sulfide Detection with a Highly Efficient Accumulation Strategy . | ANALYTICAL CHEMISTRY , 2024 , 96 (13) , 5251-5257 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Homogeneous electrochemiluminescence (ECL) has gained attention for its simplicity and stability. However, false positives due to solution background interference pose a challenge. To address this, magnetic ECL nanoparticles (Fe3O4@Ru@SiO2 NPs) were synthesized, offering easy modification, magnetic separation, and stable luminescence. These were utilized in an ECL sensor for miRNA-155 (miR-155) detection, with locked DNAzyme and substrate chain (mDNA) modified on their surface. The poor conductivity of long-chain DNA significantly impacts the conductivity and electron transfer capability of Fe3O4@Ru@SiO2 NPs, resulting in weaker ECL signals. Upon target presence, unlocked DNAzyme catalyzes mDNA cleavage, leading to shortened DNA chains and reduced density. In contrast, the presence of short-chain DNA has minimal impact on the conductivity and electron transfer capability of Fe3O4@Ru@SiO2 NPs. Simultaneously, the material surface's electronegativity decreases, weakening the electrostatic repulsion with the negatively charged electrode, resulting in the system detecting stronger ECL signals. This sensor enables homogeneous ECL detection while mitigating solution background interference through magnetic separation. Within a range of 100 fM to 10 nM, the sensor exhibits a linear relationship between ECL intensity and target concentration, with a 26.91 fM detection limit. It demonstrates high accuracy in clinical sample detection, holding significant potential for clinical diagnostics. Future integration with innovative detection strategies may further enhance sensitivity and specificity in biosensing applications.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lin, Yue , Luo, Peiqing , Luo, Fang et al. High-Sensitivity Homogeneous Detection of miRNA-155 Governed by DNA Walker-Regulated Surface DNA Density of Magnetic Electrochemiluminescence Nanoparticles [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (33) : 13710-13718 . |
| MLA | Lin, Yue et al. "High-Sensitivity Homogeneous Detection of miRNA-155 Governed by DNA Walker-Regulated Surface DNA Density of Magnetic Electrochemiluminescence Nanoparticles" . | ANALYTICAL CHEMISTRY 96 . 33 (2024) : 13710-13718 . |
| APA | Lin, Yue , Luo, Peiqing , Luo, Fang , Lin, Cuiying , Wang, Jian , Qiu, Bin et al. High-Sensitivity Homogeneous Detection of miRNA-155 Governed by DNA Walker-Regulated Surface DNA Density of Magnetic Electrochemiluminescence Nanoparticles . | ANALYTICAL CHEMISTRY , 2024 , 96 (33) , 13710-13718 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Herein, we present the development of an ultra-sensitive immobilization-free homogeneous electrochemiluminescence (ECL) biosensor, leveraging the electrostatic repulsion between a negatively charged indium tin oxide (ITO) electrode and DNA and exonuclease I (Exo I)-powered signal amplification, to achieve highly efficient detection of thrombin. Specifically, the aptamer and the complementary DNA engage in the formation of a double-stranded DNA (dsDNA) complex. This negatively charged dsDNA structure subsequently associates with a positively charged ECL indicator, namely ruthenium phenanthroline (Ru(phen)32+), resulting in the generation of the dsDNA-Ru(phen)32+ ECL probe. The negatively charged dsDNA-Ru(phen)32+ experiences electrostatic repulsion from the negatively charged ITO electrode, resulting in a low ECL signal. Nonetheless, upon the addition of thrombin, the aptamer preferentially binds to thrombin, triggering the releases of the embedded Ru (phen)32+ facilitated by Exo I and hence resulting in a robust and enhanced ECL signal. The amplified ECL signal is linearly correlated with the logarithm of thrombin concentration within a detection range spanning from 10 fmol/mL to 50 pmol/mL, with a remarkable detection limit of 3.21 fmol/mL. This strategy eliminates the need for cumbersome labeling steps, avoids the electrode modification process, overcoming the low immobilization efficiency of aptamers and poor signal transduction of indicators labeled at the end of DNA.
Keyword ：
Biomarker Biomarker Electrochemiluminescence biosensors Electrochemiluminescence biosensors Electrostatic force Electrostatic force exonuclease I exonuclease I Thrombin Thrombin
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Zheng, Zhenjie , Lin, Jiarong , Zhang, Junyi et al. Ultra-sensitive immobilization-free homogeneous electrochemiluminescence biosensor for thrombin detection via electrostatic interaction and Exo I-powered signal amplification [J]. | MICROCHEMICAL JOURNAL , 2024 , 207 . |
| MLA | Zheng, Zhenjie et al. "Ultra-sensitive immobilization-free homogeneous electrochemiluminescence biosensor for thrombin detection via electrostatic interaction and Exo I-powered signal amplification" . | MICROCHEMICAL JOURNAL 207 (2024) . |
| APA | Zheng, Zhenjie , Lin, Jiarong , Zhang, Junyi , Luo, Fang , Weng, Zuquan , Wang, Jian et al. Ultra-sensitive immobilization-free homogeneous electrochemiluminescence biosensor for thrombin detection via electrostatic interaction and Exo I-powered signal amplification . | MICROCHEMICAL JOURNAL , 2024 , 207 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
