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3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization SCIE
期刊论文 | 2026 , 178 | BIOMATERIALS ADVANCES
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Abstract :

Critical-sized bone defects caused by trauma, congenital malformation, or tumor resection remain a major challenge around the world. Current bone tissue-engineering scaffolds are partially confined by inadequate scaffold architecture design that mismatches with natural bone tissue, which affect normal biological functions like inflammation modulation and biomineralization, thus impairing bone regeneration process. Herein, a biomimetic 3D-printed BMGP scaffold composed of polydopamine (PDA)-polylactide (PLA) scaffold and black phosphorus (BP) nanosheets/manganese carbonyl (MnCO) nanosheets/gelatin methacryloyl hydrogel (named as BMG hydrogel) was developed for augmenting bone regeneration via strengthening anti-inflammatory effect and promoting in-situ biomineralization process. Through infilling the BMG hydrogel into the gradient-porous PDA-PLA scaffold, the obtained BMGP scaffold successfully mimicked cancellous and compact bone structure and extracellular matrix component in natural bone tissue. Upon being implanted into the critical-sized bone defect, a Fenton-like reaction between the MnCO nanosheet and endogenous hydrogen peroxide effectively induced carbon monoxide release, thereby improving anti-inflammatory response and facilitating macrophage reversed from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype. Meanwhile, the BP nanosheet underwent degradation and in-situ biomineralization, which accelerated calcium phosphate formation and enhanced osteogenesis. Based on in-vitro and in-vivo data, the 3D-printed BMGP scaffold that integrated structural and functional biomimicry exhibited desirable inflammatory inhibition and in-situ biomineralization performances, as well as favorable osteogenic effect in rat critical-sized femoral bone defect. In all, such biomimetic scaffold obviously propelled bone regeneration process, and provided a promising strategy for treating critical-sized bone defects in clinic.

Keyword :

3D-printing 3D-printing Biomimetic tissue engineering scaffold Biomimetic tissue engineering scaffold Bone regeneration Bone regeneration Inflammation inhibition Inflammation inhibition In-situ biomineralization In-situ biomineralization

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GB/T 7714 Wu, Dongyu , Gao, Shangjun , He, Shaohua et al. 3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization [J]. | BIOMATERIALS ADVANCES , 2026 , 178 .
MLA Wu, Dongyu et al. "3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization" . | BIOMATERIALS ADVANCES 178 (2026) .
APA Wu, Dongyu , Gao, Shangjun , He, Shaohua , Liu, Wanling , Liu, Qingwei , Lan, Siyao et al. 3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization . | BIOMATERIALS ADVANCES , 2026 , 178 .
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3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization EI
期刊论文 | 2026 , 178 | Biomaterials Advances
Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction SCIE
期刊论文 | 2025 | ADVANCED FUNCTIONAL MATERIALS
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Abstract :

Osteosarcoma (OS) is a highly aggressive and lethal malignant tumor with a 5-year overall survival rate of less than 20%, while its post-operative recovery remains suboptimal due to persistent inflammatory responses, incomplete clearance of residual tumor cells, and insufficient repair of tumor-induced large bone defects. Herein, a self-adaptive multi-functional RPSH hydrogel is successfully prepared by integrating a self-assembled 1-bromoacetyl-3,3-dinitroazetidine (RRx-001)/indocyanine green (ICG)@diselenide nanoparticle (R/I@SeNP) into a dual-network polyacrylamide/sodium alginate/hyaluronic acid (PAAm/SA/HA) hydrogel matrix. Initially, high molecular weight HA effectively suppresses the NF-kappa B pathway and induces macrophage polarization toward the M2 phenotype within 24 h, thereby reversing inflammatory microenvironments following OS resection. Then, dual-responsive R/I@SeNP enables a multi-modal anti-cancer approach by up-regulating levels of reactive oxygen/nitrogen species and generating RSeH or the immune checkpoint inhibitor RSeO(OH) with a tumor growth inhibition rate of 72.84% +/- 6.75% at three weeks post-surgery. Remarkably, the RPSH hydrogel promotes substantial new-bone formation and achieves a bone volume/total tissue volume (BV/TV) ratio of 59.03% +/- 9.41% following eight weeks of implantation by regulating the osteogenic-osteoclastic balance, demonstrating its sustained ability to create microenvironments favorable for bone regeneration. This self-adaptive hydrogel-based strategy offers promising insights and potential benefits for improving post-operative OS therapy.

Keyword :

inflammation resolution inflammation resolution multi-modal tumor inhibition multi-modal tumor inhibition osteogenesis osteogenesis osteosarcoma treatment osteosarcoma treatment self-adaptive hydrogel self-adaptive hydrogel

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GB/T 7714 Lin, Hairong , Jin, Xinmeng , Cao, Yang et al. Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 .
MLA Lin, Hairong et al. "Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction" . | ADVANCED FUNCTIONAL MATERIALS (2025) .
APA Lin, Hairong , Jin, Xinmeng , Cao, Yang , Ruan, Renjie , Liu, Changhua , Huang, Shandeng et al. Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction . | ADVANCED FUNCTIONAL MATERIALS , 2025 .
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Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction Scopus
期刊论文 | 2025 | Advanced Functional Materials
Vascular Intima-Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual-Modal Anti-Coagulation and Self-Adaptive Immunomodulation Scopus
期刊论文 | 2025 | Advanced Functional Materials
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Abstract :

Although central venous catheters (CVCs) exhibit promising hemocompatibility and interfacial stability, their clinical applications are constrained by the inability to counteract thrombus and acute inflammation. Herein, a novel vascular intima-biomimetic bilayered hydrogel coating is designed to mitigate clinical thrombotic and inflammatory complications. Firstly, passive anti-coagulation shield established by hydrophilic groups orchestrated robust hydration shells, which achieved non-specific adhesion resistance against blood compositions. Active anti-coagulation mode was simultaneously established by dynamic thiol/sulfonic redox moieties, realizing synergetic inhibition effects on the activity of coagulation factors and self-activation of coagulation cascade. Secondly, the hydrogel presented a free radicals-scavenging rate of 79.42% ± 1.34% coupled with macrophage phenotype remodeling, effectively constructing an ideal anti-bacterial microenvironment for repair of oxidative stress-mediated endothelial damage. More interestingly, such biomimetic bilayered hydrogel coating achieved exceptional adhesion stability toward CVCs, meanwhile its vascular intima-mimetic modulus reduced mismatch-induced endothelial injury, thereby ensuring long-term interfacial integrity and implant safety. According to in vivo and ex vivo results of rat subcutaneous implantation and rabbit arteriovenous (AV) shunts model, the coating significantly decreased catheter occlusion rate (0.90% ± 0.64%), suppressed F1+2 accumulation, and inhibited TNF-α expression. Overall, the hydrogel coating with synergetic anti-coagulant/anti-inflammatory functionalities established an effective bio-interfacial for clinical indwelling device safety, demonstrating particularly promising applications. © 2025 Wiley-VCH GmbH.

Keyword :

active/passive·anti-coagulation active/passive·anti-coagulation bilayer hydrogel coating bilayer hydrogel coating dynamic anti-inflammation dynamic anti-inflammation strong interfacial adhesion strong interfacial adhesion vascular intima-biomimetic vascular intima-biomimetic

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GB/T 7714 Hu, X. , Mou, X. , Pan, G. et al. Vascular Intima-Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual-Modal Anti-Coagulation and Self-Adaptive Immunomodulation [J]. | Advanced Functional Materials , 2025 .
MLA Hu, X. et al. "Vascular Intima-Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual-Modal Anti-Coagulation and Self-Adaptive Immunomodulation" . | Advanced Functional Materials (2025) .
APA Hu, X. , Mou, X. , Pan, G. , Liu, Y. , Song, W. , Xiao, P. et al. Vascular Intima-Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual-Modal Anti-Coagulation and Self-Adaptive Immunomodulation . | Advanced Functional Materials , 2025 .
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Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds SCIE
期刊论文 | 2025 , 35 (22) | ADVANCED FUNCTIONAL MATERIALS
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Abstract :

Healing of chronic wounds becomes a global health issue due to increasing incidence and associated burdens, and therefore promoting tissue-remodeling and monitoring wound-status visually are of particular significance. Herein, an electronic-skin patch (TENG-gel) composed by polydimethylsiloxane/polytetrafluoroethylene film, eutectic gallium-indium (E-GaIn), and quaternary chitosan/polyacrylamide/sodium alginate@molybdenum disulfide (MoS2) nanosheet (H-QPS@MoS2) composite hydrogel is assembled layer-by-layer. First, the TENG-gel realizes multimodal antibacterial by integrating peroxidase-like activity, photothermal therapy, and nano-knife effect, which eliminates both Gram-positive/negative bacteria with killing ratio of above 95%. Besides, electrical stimulation generated from the TENG-gel promotes migration of fibroblasts after an incubation of 48 h by activating signaling pathways, and meanwhile accelerates vascularization by secreting different growth factors of CD31, VEGF, and TGF-beta. Through providing an ideal microenvironment for tissue repair, the TENG-gel achieves 1.6-fold new hair follicles and 2.4-fold collagen deposition compared with those of the control group. More interestingly, dual temperature-/strain-sensing performance enables the TENG-gel with capability of monitoring wound status or reminding external danger signals in real-time dependent on variational electrical signals. Overall, unique advantages of such smart electronic-skin patch provide a personalized medicine strategy for realizing tissue reconstruction and monitoring synchronously.

Keyword :

chronic wounds chronic wounds MoS2 nanosheets MoS2 nanosheets multimodal antibacterial multimodal antibacterial real-time monitoring real-time monitoring wireless self-powered wireless self-powered

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GB/T 7714 Liu, Wanling , Ye, Juncheng , Wang, Yanlang et al. Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (22) .
MLA Liu, Wanling et al. "Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds" . | ADVANCED FUNCTIONAL MATERIALS 35 . 22 (2025) .
APA Liu, Wanling , Ye, Juncheng , Wang, Yanlang , Xu, Xiaobo , Gao, Yujie , Liu, Kangyu et al. Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds . | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (22) .
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Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds EI
期刊论文 | 2025 , 35 (22) | Advanced Functional Materials
Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds Scopus
期刊论文 | 2025 , 35 (22) | Advanced Functional Materials
Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration SCIE
期刊论文 | 2025 , 19 (15) , 14707-14726 | ACS NANO
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Abstract :

Critical-sized bone defects present a clinical challenge due to their limited self-repair capacity. Application of bone tissue-engineering scaffolds often overlooks the dynamic modulation of the microenvironment, resulting in unsatisfactory bone-regeneration outcomes. In this study, a bone morphogenetic protein-2-derived peptide-loaded honeycomb manganese dioxide (BHM) nanozyme was incorporated into a composite hydrogel (BHM@CG) composed of l-arginine-modified methacrylated carboxymethyl chitosan and gallic acid-grafted methacrylated gelatin. This hydrogel demonstrated a cascade-regulated enhancement of hemostasis, antibacterial activity, anti-inflammatory effects, and osteogenesis. Initially, the BHM@CG hydrogel achieved rapid hemostasis by quickly adhering to irregular defects upon injury. Subsequently, it displayed robust antibacterial activity through synergistic hydrogen bonding, hydrophobic interactions, and cationic interactions. Meanwhile, the BHM nanozyme and polyphenol groups from gallic acid effectively eliminated reactive oxygen species, enabling long-term inflammation regulation. Finally, sustained release of bioactive components promoted cell migration, angiogenesis, and osteogenesis, achieving a bone-formation rate of nearly 40% in a critical-sized calvarial defect model by week 8. More interestingly, the hydrogel also demonstrated efficient antibacterial and bone-regeneration capabilities in an infected critical-sized calvarial defect model. Overall, this hydrogel dynamically modulated the bone-defect microenvironment and effectively enhanced bone regeneration, offering a promising strategy for critical-sized bone-defect repair.

Keyword :

bone regeneration bone regeneration cascade-regulation cascade-regulation hemostasis hemostasis inflammation resolution inflammation resolution nanozyme nanozyme

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GB/T 7714 Chen, Jiaxin , Zhao, Ye , Ruan, Renjie et al. Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration [J]. | ACS NANO , 2025 , 19 (15) : 14707-14726 .
MLA Chen, Jiaxin et al. "Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration" . | ACS NANO 19 . 15 (2025) : 14707-14726 .
APA Chen, Jiaxin , Zhao, Ye , Ruan, Renjie , Feng, Xiao , Niu, Zexuan , Pan, Lei et al. Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration . | ACS NANO , 2025 , 19 (15) , 14707-14726 .
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Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration Scopus
期刊论文 | 2025 , 19 (15) , 14707-14726 | ACS Nano
Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration EI
期刊论文 | 2025 , 19 (15) , 14707-14726 | ACS Nano
Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration Scopus
期刊论文 | 2025 | ACS Nano
Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair SCIE
期刊论文 | 2025 , 12 (28) | ADVANCED SCIENCE
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Abstract :

It is highly desirable but still remains challenging to develop high-performance hydrogels with satisfactory mechanical properties for tissue engineering. Here, anisotropic yet transparent hydrogels (AHs) are prepared for tendon repair via a facile "poor solvent evaporation assisted hot-stretching" strategy. AHs have great mechanical properties with tensile strength, toughness, and fracture energy as high as 33.14 +/- 2.05 MPa, 44.1 +/- 3.5 MJ m(-3), and 106.18 +/- 7.2 kJ m(-2), respectively. Especially, AHs show unique flaw-insensitive characteristics, and cracks can only deflect along the fiber alignment direction rather than propagate transverse to this direction, showing an interesting self-protection function. The high strength, toughness, and fatigue resistance originate from the hierarchal structure of AHs, i.e., the densified polymeric network comprising fiber bundles and nanofibrils with aligned macromolecular chains, crystalline domains, and intermolecular hydrogen bonds. AHs with superior biocompatibility and swelling resistance can be used to repair rat tendons, and implantation of AHs can promote collagen regeneration for the tendon repair. This study provides a new method to fabricate strong and anti-fatigue hydrogels as a new class of promising materials for soft tissues.

Keyword :

anisotropic hydrogels anisotropic hydrogels flaw-insensitivity flaw-insensitivity hot-stretching hot-stretching poor solvent evaporation poor solvent evaporation tendon repair tendon repair

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GB/T 7714 Li, Huamin , Zhang, Ying , Wu, Haidi et al. Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair [J]. | ADVANCED SCIENCE , 2025 , 12 (28) .
MLA Li, Huamin et al. "Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair" . | ADVANCED SCIENCE 12 . 28 (2025) .
APA Li, Huamin , Zhang, Ying , Wu, Haidi , Liu, Zhanqi , Guan, Cheng , Zhang, Jin et al. Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair . | ADVANCED SCIENCE , 2025 , 12 (28) .
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Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair Scopus
期刊论文 | 2025 , 12 (28) | Advanced Science
Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair EI
期刊论文 | 2025 , 12 (28) | Advanced Science
Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration SCIE
期刊论文 | 2024 , 16 (7) , 8538-8553 | ACS APPLIED MATERIALS & INTERFACES
WoS CC Cited Count: 6
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Abstract :

Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment. Herein, a bionic bilayer scaffold constituting croconaine dye-polyethylene glycol@sodium alginate hydrogel and poly(L-lactide)/hydroxyapatite polymer matrix is fabricated to simultaneously achieve a highly efficient killing of osteosarcoma and an accelerated osteochondral regeneration. First, biomimetic osteochondral structure along with adequate interfacial interaction of the bilayer scaffold provide a structural reinforcement for transverse osseointegration and osteochondral regeneration, as evidenced by upregulated specific expressions of collagen type-I, osteopontin, and runt-related transcription factor 2. Meanwhile, thermal ablation of the synthesized nanoparticles and mitochondrial dysfunction caused by continuously released hydroxyapatite induce residual tumor necrosis synergistically. To validate the capabilities of inhibiting tumor growth and promoting osteochondral regeneration of our proposed scaffold, a novel orthotopic osteosarcoma model simulating clinical treatment scenarios of bone tumors is established on rats. Based on amounts of in vitro and in vivo results, an effective killing of osteosarcoma and a suitable osteal-microenvironment modulation of such bionic bilayer composite scaffold are achieved, which provides insightful implications for photonic hyperthermia therapy against osteosarcoma and following osseous tissue regeneration.

Keyword :

bilayer scaffold bilayer scaffold biomaterials biomaterials orthotopicosteosarcoma orthotopicosteosarcoma osteochondral regeneration osteochondral regeneration photonic hyperthermiatherapy photonic hyperthermiatherapy

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GB/T 7714 Gong, Chenchi , Wang, Jun , Tang, Faqiang et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) : 8538-8553 .
MLA Gong, Chenchi et al. "Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration" . | ACS APPLIED MATERIALS & INTERFACES 16 . 7 (2024) : 8538-8553 .
APA Gong, Chenchi , Wang, Jun , Tang, Faqiang , Tong, Dongmei , Wang, Ziyi , Zhou, Zijie et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) , 8538-8553 .
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Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration EI
期刊论文 | 2024 , 16 (7) , 8538-8553 | ACS Applied Materials and Interfaces
Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration Scopus
期刊论文 | 2024 , 16 (7) , 8538-8553 | ACS Applied Materials and Interfaces
A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair SCIE
期刊论文 | 2024 , 36 (3) | ADVANCED MATERIALS
WoS CC Cited Count: 35
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Abstract :

Extracellular vesicles (EVs) have inherent advantages over cell-based therapies in regenerative medicine because of their cargos of abundant bioactive cues. Several strategies are proposed to tune EVs production in vitro. However, it remains a challenge for manipulation of EVs production in vivo, which poses significant difficulties for EVs-based therapies that aim to promote tissue regeneration, particularly for long-term treatment of diseases like peripheral neuropathy. Herein, a superparamagnetic nanocomposite scaffold capable of controlling EVs production on-demand is constructed by incorporating polyethyleneglycol/polyethyleneimine modified superparamagnetic nanoparticles into a polyacrylamide/hyaluronic acid double-network hydrogel (Mag-gel). The Mag-gel is highly sensitive to a rotating magnetic field (RMF), and can act as mechano-stimulative platform to exert micro/nanoscale forces on encapsulated Schwann cells (SCs), an essential glial cell in supporting nerve regeneration. By switching the ON/OFF state of the RMF, the Mag-gel can scale up local production of SCs-derived EVs (SCs-EVs) both in vitro and in vivo. Further transcriptome sequencing indicates an enrichment of transcripts favorable in axon growth, angiogenesis, and inflammatory regulation of SCs-EVs in the Mag-gel with RMF, which ultimately results in optimized nerve repair in vivo. Overall, this research provides a noninvasive and remotely time-scheduled method for fine-tuning EVs-based therapies to accelerate tissue regeneration, including that of peripheral nerves. A Mag-gel with applied rotating magnetic field (RMF) serves as a mechano-stimulative platform to exert micro/nanoscale forces to nearby Schwann cells, which can subsequently scale up local extracellular vesicles (EVs) production both in vitro and in vivo. As a non-invasive strategy, application of an RMF to manipulate the local EVs production via the Mag-gel offers a remote time-scheduled approach to optimize the process of peripheral nerve regeneration.image

Keyword :

extracellular vesicles extracellular vesicles magnetic nerve scaffolds magnetic nerve scaffolds mechanical actuation mechanical actuation nerve regeneration nerve regeneration Schwann cells Schwann cells

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GB/T 7714 Xia, Bing , Gao, Xue , Qian, Jiaqi et al. A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair [J]. | ADVANCED MATERIALS , 2024 , 36 (3) .
MLA Xia, Bing et al. "A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair" . | ADVANCED MATERIALS 36 . 3 (2024) .
APA Xia, Bing , Gao, Xue , Qian, Jiaqi , Li, Shengyou , Yu, Beibei , Hao, Yiming et al. A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair . | ADVANCED MATERIALS , 2024 , 36 (3) .
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A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral Nerve Repair Scopus
期刊论文 | 2024 , 36 (3) | Advanced Materials
Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors SCIE
期刊论文 | 2024 , 6 (4) , 1140-1150 | ACS MATERIALS LETTERS
WoS CC Cited Count: 31
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Abstract :

Conductive organohydrogels with flexibility and biocompatibility have attracted extensive attention in bioelectronic devices. However, poor mechanical properties and crack propagation resistance have severely limited their applications. Herein, strong, tough, and ionically conductive organogels (ICOs) with outstanding fatigue resistance are prepared based on simultaneous construction of dense cross-linked polymer network with numerous crystalline domains and ionically conductive network during the solvent exchange. ICOs show excellent mechanical properties with tensile strength and elongation at break as high as 16.7 +/- 0.9 MPa and 1112.4 +/- 120.3%, respectively. Moreover, the fracture energy and fatigue threshold can reach 34.0 +/- 4.7 KJ/m(2) and 561.3 +/- 59.6 J/m(2), respectively, exhibiting outstanding crack resistant properties. ICOs with antifreezing performance are used for strain sensing with a linear working strain up to 80% and superior cycling stability, and the ICO strain sensor can monitor various body motions. The mechanically strong and antifatigue organogels show promising applications in flexible and smart electronics even in extreme environments.

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GB/T 7714 Wang, Yuqing , Wu, Yongchuan , Liu, Yuntao et al. Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors [J]. | ACS MATERIALS LETTERS , 2024 , 6 (4) : 1140-1150 .
MLA Wang, Yuqing et al. "Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors" . | ACS MATERIALS LETTERS 6 . 4 (2024) : 1140-1150 .
APA Wang, Yuqing , Wu, Yongchuan , Liu, Yuntao , Wu, Haidi , Xiao, Wei , Zhang, Hechuan et al. Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors . | ACS MATERIALS LETTERS , 2024 , 6 (4) , 1140-1150 .
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Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors EI
期刊论文 | 2024 , 6 (4) , 1140-1150 | ACS Materials Letters
Strong, Antifatigue, and Ionically Conductive Organogels for High-Performance Strain Sensors Scopus
期刊论文 | 2024 , 6 (4) , 1140-1150 | ACS Materials Letters
Engineering customized nanovaccines for enhanced cancer immunotherapy SCIE CSCD
期刊论文 | 2024 , 36 , 330-357 | BIOACTIVE MATERIALS
WoS CC Cited Count: 12
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Abstract :

Nanovaccines have gathered significant attention for their potential to elicit tumor-specific immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines still encounter considerable challenges such as low delivery efficiency, limited targeting ability, and suboptimal efficacy. With an aim of addressing these issues, engineering customized nanovaccines through modification or functionalization has emerged as a promising approach. These tailored nanovaccines not only enhance antigen presentation, but also effectively modulate immunosuppression within the tumor microenvironment. Specifically, they are distinguished by their diverse sizes, shapes, charges, structures, and unique physicochemical properties, along with targeting ligands. These features of nanovaccines facilitate lymph node accumulation and activation/regulation of immune cells. This overview of bespoke nanovaccines underscores their potential in both prophylactic and therapeutic applications, offering insights into their future development and role in cancer immunotherapy.

Keyword :

Customized structure Customized structure Enhanced cancer immunotherapy Enhanced cancer immunotherapy Nanovaccines Nanovaccines Prophylactic and therapeutic applications Prophylactic and therapeutic applications Tailored-ligand Tailored-ligand

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GB/T 7714 Guo, Jinyu , Liu, Changhua , Qi, Zhaoyang et al. Engineering customized nanovaccines for enhanced cancer immunotherapy [J]. | BIOACTIVE MATERIALS , 2024 , 36 : 330-357 .
MLA Guo, Jinyu et al. "Engineering customized nanovaccines for enhanced cancer immunotherapy" . | BIOACTIVE MATERIALS 36 (2024) : 330-357 .
APA Guo, Jinyu , Liu, Changhua , Qi, Zhaoyang , Qiu, Ting , Zhang, Jin , Yang, Huanghao . Engineering customized nanovaccines for enhanced cancer immunotherapy . | BIOACTIVE MATERIALS , 2024 , 36 , 330-357 .
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Engineering customized nanovaccines for enhanced cancer immunotherapy Scopus CSCD
期刊论文 | 2024 , 36 , 330-357 | Bioactive Materials
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