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学者姓名：张进
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Abstract ：
Critical-sized bone defects present a clinical challenge due to their limited self-repair capacity. Application of bone tissue-engineering scaffolds often overlooks the dynamic modulation of the microenvironment, resulting in unsatisfactory bone-regeneration outcomes. In this study, a bone morphogenetic protein-2-derived peptide-loaded honeycomb manganese dioxide (BHM) nanozyme was incorporated into a composite hydrogel (BHM@CG) composed of l-arginine-modified methacrylated carboxymethyl chitosan and gallic acid-grafted methacrylated gelatin. This hydrogel demonstrated a cascade-regulated enhancement of hemostasis, antibacterial activity, anti-inflammatory effects, and osteogenesis. Initially, the BHM@CG hydrogel achieved rapid hemostasis by quickly adhering to irregular defects upon injury. Subsequently, it displayed robust antibacterial activity through synergistic hydrogen bonding, hydrophobic interactions, and cationic interactions. Meanwhile, the BHM nanozyme and polyphenol groups from gallic acid effectively eliminated reactive oxygen species, enabling long-term inflammation regulation. Finally, sustained release of bioactive components promoted cell migration, angiogenesis, and osteogenesis, achieving a bone-formation rate of nearly 40% in a critical-sized calvarial defect model by week 8. More interestingly, the hydrogel also demonstrated efficient antibacterial and bone-regeneration capabilities in an infected critical-sized calvarial defect model. Overall, this hydrogel dynamically modulated the bone-defect microenvironment and effectively enhanced bone regeneration, offering a promising strategy for critical-sized bone-defect repair.
Keyword ：
bone regeneration bone regeneration cascade-regulation cascade-regulation hemostasis hemostasis inflammation resolution inflammation resolution nanozyme nanozyme
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| GB/T 7714 | Chen, Jiaxin , Zhao, Ye , Ruan, Renjie et al. Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration [J]. | ACS NANO , 2025 . |
| MLA | Chen, Jiaxin et al. "Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration" . | ACS NANO (2025) . |
| APA | Chen, Jiaxin , Zhao, Ye , Ruan, Renjie , Feng, Xiao , Niu, Zexuan , Pan, Lei et al. Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration . | ACS NANO , 2025 . |
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Traditional hepatocellular carcinoma-chip models lack the cell structure and microenvironments necessary for high pathophysiological correlation, leading to low accuracy in predicting drug efficacy and high production costs. This study proposed a decellularized hepatocellular carcinoma-on-a-chip model to screen anti-tumor nanomedicine. In this model, human hepatocellular carcinoma (HepG2) and human normal liver cells (L02) were co-cultured on a three-dimensional (3D) decellularized extracellular matrix (dECM) in vitro to mimic the tumor microenvironments of human hepatocellular carcinoma in vivo. Additionally, a smart nanomedicine was developed by encapsulating doxorubicin (DOX) into the ferric oxide (Fe3O4)-incorporated liposome nanovesicle (NLV/Fe+DOX). NLV/Fe+DOX selectively killed 78.59% ± 6.78% of HepG2 cells through targeted delivery and synergistic chemo-chemodynamic-photothermal therapies, while the viability of surrounding L02 cells on the chip model retained high, at over 90.0%. The drug efficacy tested using this unique chip model correlated well with the results of cellular and animal experiments. In summary, our proposed hepatocellular carcinoma-chip model is a low-cost yet accurate drug-testing platform with significant potential for drug screening. © 2024 Elsevier B.V.
Keyword ：
Decellularized extracellular matrix Decellularized extracellular matrix Drug screening Drug screening Hepatocellular carcinoma-on-a-chip model Hepatocellular carcinoma-on-a-chip model Multi-functional nanomedicine Multi-functional nanomedicine Synergistic tumor therapy Synergistic tumor therapy
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| GB/T 7714 | Chen, Y. , Lin, G. , Wang, Z. et al. Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip [J]. | Biosensors and Bioelectronics , 2024 , 264 . |
| MLA | Chen, Y. et al. "Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip" . | Biosensors and Bioelectronics 264 (2024) . |
| APA | Chen, Y. , Lin, G. , Wang, Z. , He, J. , Yang, G. , Lin, Z. et al. Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip . | Biosensors and Bioelectronics , 2024 , 264 . |
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Besides their limited preservation capacity and low biosafety, traditional fruit preservation procedures exacerbate “white pollution” because they utilize excessive plastic. Herein, an environmentally friendly one-pot method was developed to obtain degradable polyvinyl alcohol (PVA), where the hydroxyl radicals generated through the reaction between hydrogen peroxide (H2O2) and iron ions functioned to oxidize PVA. The oxidized PVA (OPVA-1.0) with abundant ketone groups, reduced crystallinity, and short molecular chains was completely degraded into H2O and CO2 after being buried in the soil for ∼60 days. An improvement in its degradation rate did not weaken the mechanical properties of OPVA-1.0 compared to other modified PVA films because the adverse effect of decreased crystallinity on its mechanical performance was offset by its ion coordination. Alternatively, the tensile strength or toughness of OPVA-1.0 was enhanced due to its internal multi-level interactions including molecular chain entanglement, hydrogen bonding, and metal coordination bonds. More interestingly, OPVA-1.0 was water-welded into various products in a recyclable way owing to its reversible physical bonds, where it was sprayed, dipped, or brushed conformally onto different perishable fruits to delay their ripening by 5-14 days. Based on the cellular biocompatibility and biosafety evaluations in mice, OPVA-1.0 obtained by the facile oxidation strategy was demonstrated to alleviate “white pollution” and delay the ripening of fruits effectively. © 2024 The Royal Society of Chemistry.
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| GB/T 7714 | Lu, Y. , Liu, G. , Zhang, K. et al. Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation [J]. | Journal of Materials Chemistry B , 2024 , 12 (35) : 8716-8732 . |
| MLA | Lu, Y. et al. "Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation" . | Journal of Materials Chemistry B 12 . 35 (2024) : 8716-8732 . |
| APA | Lu, Y. , Liu, G. , Zhang, K. , Wang, Z. , Xiao, P. , Liu, C. et al. Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation . | Journal of Materials Chemistry B , 2024 , 12 (35) , 8716-8732 . |
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Abstract ：
Besides their limited preservation capacity and low biosafety, traditional fruit preservation procedures exacerbate "white pollution" because they utilize excessive plastic. Herein, an environmentally friendly one-pot method was developed to obtain degradable polyvinyl alcohol (PVA), where the hydroxyl radicals generated through the reaction between hydrogen peroxide (H2O2) and iron ions functioned to oxidize PVA. The oxidized PVA (OPVA-1.0) with abundant ketone groups, reduced crystallinity, and short molecular chains was completely degraded into H2O and CO2 after being buried in the soil for similar to 60 days. An improvement in its degradation rate did not weaken the mechanical properties of OPVA-1.0 compared to other modified PVA films because the adverse effect of decreased crystallinity on its mechanical performance was offset by its ion coordination. Alternatively, the tensile strength or toughness of OPVA-1.0 was enhanced due to its internal multi-level interactions including molecular chain entanglement, hydrogen bonding, and metal coordination bonds. More interestingly, OPVA-1.0 was water-welded into various products in a recyclable way owing to its reversible physical bonds, where it was sprayed, dipped, or brushed conformally onto different perishable fruits to delay their ripening by 5-14 days. Based on the cellular biocompatibility and biosafety evaluations in mice, OPVA-1.0 obtained by the facile oxidation strategy was demonstrated to alleviate "white pollution" and delay the ripening of fruits effectively. Oxidized PVA (OPVA-1.0) obtained by one-pot method is completely degraded in soil, which is further sprayed, dipped, or brushed conformally onto different perishable fruits to delay the ripening by 5-14 days as ideal packaging materials.
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| GB/T 7714 | Lu, Yi , Liu, Guoming , Zhang, Kaixin et al. Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (35) : 8716-8732 . |
| MLA | Lu, Yi et al. "Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation" . | JOURNAL OF MATERIALS CHEMISTRY B 12 . 35 (2024) : 8716-8732 . |
| APA | Lu, Yi , Liu, Guoming , Zhang, Kaixin , Wang, Ziyi , Xiao, Peijie , Liu, Changhua et al. Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation . | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (35) , 8716-8732 . |
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Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites re-mains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide bonds.The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glu-tathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesi-cle for tumor cells.Based on in-vitro results,a controlled-release behavior of DOX upon a dual-responsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of ROS.After an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations.Overall,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcuta-neous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.
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| GB/T 7714 | Jinyu Guo , Yandai Lin , Shaohua He et al. Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | 中国化学快报（英文版） , 2024 , 35 (9) : 296-302 . |
| MLA | Jinyu Guo et al. "Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | 中国化学快报（英文版） 35 . 9 (2024) : 296-302 . |
| APA | Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan et al. Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | 中国化学快报（英文版） , 2024 , 35 (9) , 296-302 . |
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Hydrogel coatings of catheters have attracted extensive attention in the field of medical devices due to its hydrophilicity and softness, while scarcities of Janus adhesion, adaptive antibacterial property, and real-time disease monitoring restricted their clinical translational applications. Herein, a novel hydrogel coating with water-responsive Janus adhesion and acidity-triggered transformation was fabricated for antibacterial treatment and fluorescence diagnosis of catheters-associated infections. First, a sufficient adhesion strength of 44.6 +/- 1.9 kPa effectively prevented shedding of the hydrogel coating during catheterization, and meanwhile a super- lubricated layer with an extremely-low coefficient of friction of about 0.03 was formed to reduce friction pain in an aqueous microenvironment. Furthermore, size and fluorescence intensity of chitosan/bovine serum albumin-gold nanoparticles within the hydrogel were varied with pH due to acidity-triggered transformation, where an adaptive release of antibacterial nanoparticles was achieved to reduce biofilms formation and alleviate inflammation degree synergistically. More importantly, such antibacterial treatment was monitored in real-time dependent on an on-off variation of fluorescence intensity. Overall, amounts of in-vitro and in-vivo results performed in rabbit urinary tract infection model and porcine tracheal intubation model fully suggested our newly- synthesized hydrogel coating on universal medical devices showed a promising potential for integrated diagnosis and treatment of catheters-associated infections.
Keyword ：
Acidity-triggered transformation Acidity-triggered transformation Adaptive antibacterial treatment and diagnosis Adaptive antibacterial treatment and diagnosis Catheters-associated infections Catheters-associated infections Hydrogel coating Hydrogel coating Water-responsive Janus adhesion Water-responsive Janus adhesion
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| GB/T 7714 | Liu, Yanyun , Li, Ming , Zheng, Ying et al. Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and fluorescence diagnosis [J]. | CHEMICAL ENGINEERING JOURNAL , 2024 , 481 . |
| MLA | Liu, Yanyun et al. "Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and fluorescence diagnosis" . | CHEMICAL ENGINEERING JOURNAL 481 (2024) . |
| APA | Liu, Yanyun , Li, Ming , Zheng, Ying , Liu, Changhua , Cao, Yang , Guo, Wei et al. Hydrogel coatings on universal medical devices with water-responsive Janus adhesion and acidity-triggered transformation for adaptive antibacterial treatment and fluorescence diagnosis . | CHEMICAL ENGINEERING JOURNAL , 2024 , 481 . |
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In situ disc regeneration is a meticulously orchestrated process, which involves cell recruitment, proliferation and differentiation within a local inflammatory niche. Thus far, it remains a challenge to establish a multi-staged regulatory framework for coordinating these cellular events, therefore leading to unsatisfactory outcome. This study constructs a super paramagnetically-responsive cellular gel, incorporating superparamagnetic iron oxide nanoparticles (SPIONs) and aptamer-modified palladium-hydrogen nanozymes (PdH-Apt) into a double-network polyacrylamide/hyaluronic acid (PAAm/HA) hydrogel. The Aptamer DB67 within magnetic hydrogel (Mag-gel) showed a high affinity for disialoganglioside (GD2), a specific membrane ligand of nucleus pulposus stem cells (NPSCs), to precisely recruit them to the injury site. The Mag-gel exhibits remarkable sensitivity to a magnetic field (MF), which exerts tunable micro/nano-scale forces on recruited NPSCs and triggers cytoskeletal remodeling, consequently boosting cell expansion in the early stage. By altering the parameters of MF, the mechanical cues within the hydrogel facilitates differentiation of NPSCs into nucleus pulposus cells to restore disc structure in the later stage. Furthermore, the PdH nanozymes within the Mag-gel mitigate the harsh inflammatory microenvironment, favoring cell survival and disc regeneration. This study presents a remote and multi-staged strategy for chronologically regulating endogenous stem cell fate, supporting disc regeneration without invasive procedures. The superparamagnetic-responsive hydrogel integrates SPIONs and aptamer-modified PdH nanozymes to selectively recruit endogenous stem cells and enhance their proliferation and differentiation through adjustable magnetic fields, while also improving the inflammatory microenvironment. This study introduces a remote and multi-staged strategy for chronologically regulating endogenous stem cell fate in endogenous regeneration. image
Keyword ：
intervertebral disc regeneration intervertebral disc regeneration mechanical stimulation mechanical stimulation nucleus pulposus stem cells nucleus pulposus stem cells superparamagnetic hydrogel superparamagnetic hydrogel
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| GB/T 7714 | Xue, Borui , Peng, Yan , Zhang, Yongfeng et al. A Novel Superparamagnetic-Responsive Hydrogel Facilitates Disc Regeneration by Orchestrating Cell Recruitment, Proliferation, and Differentiation within Hostile Inflammatory Niche [J]. | ADVANCED SCIENCE , 2024 , 11 (44) . |
| MLA | Xue, Borui et al. "A Novel Superparamagnetic-Responsive Hydrogel Facilitates Disc Regeneration by Orchestrating Cell Recruitment, Proliferation, and Differentiation within Hostile Inflammatory Niche" . | ADVANCED SCIENCE 11 . 44 (2024) . |
| APA | Xue, Borui , Peng, Yan , Zhang, Yongfeng , Yang, Shijie , Zheng, Yi , Hu, Huiling et al. A Novel Superparamagnetic-Responsive Hydrogel Facilitates Disc Regeneration by Orchestrating Cell Recruitment, Proliferation, and Differentiation within Hostile Inflammatory Niche . | ADVANCED SCIENCE , 2024 , 11 (44) . |
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Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment. Herein, a bionic bilayer scaffold constituting croconaine dye-polyethylene glycol@sodium alginate hydrogel and poly(L-lactide)/hydroxyapatite polymer matrix is fabricated to simultaneously achieve a highly efficient killing of osteosarcoma and an accelerated osteochondral regeneration. First, biomimetic osteochondral structure along with adequate interfacial interaction of the bilayer scaffold provide a structural reinforcement for transverse osseointegration and osteochondral regeneration, as evidenced by upregulated specific expressions of collagen type-I, osteopontin, and runt-related transcription factor 2. Meanwhile, thermal ablation of the synthesized nanoparticles and mitochondrial dysfunction caused by continuously released hydroxyapatite induce residual tumor necrosis synergistically. To validate the capabilities of inhibiting tumor growth and promoting osteochondral regeneration of our proposed scaffold, a novel orthotopic osteosarcoma model simulating clinical treatment scenarios of bone tumors is established on rats. Based on amounts of in vitro and in vivo results, an effective killing of osteosarcoma and a suitable osteal-microenvironment modulation of such bionic bilayer composite scaffold are achieved, which provides insightful implications for photonic hyperthermia therapy against osteosarcoma and following osseous tissue regeneration.
Keyword ：
bilayer scaffold bilayer scaffold biomaterials biomaterials orthotopicosteosarcoma orthotopicosteosarcoma osteochondral regeneration osteochondral regeneration photonic hyperthermiatherapy photonic hyperthermiatherapy
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| GB/T 7714 | Gong, Chenchi , Wang, Jun , Tang, Faqiang et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration [J]. | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) : 8538-8553 . |
| MLA | Gong, Chenchi et al. "Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration" . | ACS APPLIED MATERIALS & INTERFACES 16 . 7 (2024) : 8538-8553 . |
| APA | Gong, Chenchi , Wang, Jun , Tang, Faqiang , Tong, Dongmei , Wang, Ziyi , Zhou, Zijie et al. Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration . | ACS APPLIED MATERIALS & INTERFACES , 2024 , 16 (7) , 8538-8553 . |
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Structural engineering is an appealing means to modulate osteogenesis without the intervention of exogenous cells or therapeutic agents. In this work, a novel 3D scaffold with anisotropic micropores and nanotopographical patterns is developed. Scaffolds with oriented pores are fabricated via the selective extraction of water-soluble polyethylene oxide from its poly(epsilon-caprolactone) co-continuous mixture and uniaxial stretching. The plate apatite-like lamellae are subsequently hatched on the pore walls through surface-induced epitaxial crystallization. Such a unique geometric architecture yields a synergistic effect on the osteogenic capability. The prepared scaffold leads to a 19.2% and 128.0% increase in the alkaline phosphatase activity of rat bone mesenchymal stem cells compared to that of the scaffolds with only oriented pores and only nanotopographical patterns, respectively. It also induces the greatest upregulation of osteogenic-related gene expression in vitro. The cranial defect repair results demonstrate that the prepared scaffold effectively promotes new bone regeneration, as indicated by a 350% increase in collagen I expression in vivo compared to the isotropic porous scaffold without surface nanotopology after implantation for 14 weeks. Overall, this work provides geometric motifs for the transduction of biophysical cues in 3D porous scaffolds, which is a promising option for tissue engineering applications. This study presents a 3D scaffold featuring anisotropic micropores and nanotopographical patterns to modulate osteogenesis. The scaffold, fabricated through selective extraction, uniaxial stretching, and surface-induced epitaxial crystallization, possesses a unique geometric architecture, which significantly enhances bone mesenchymal stem cell proliferation and osteogenic differentiation, leading to effective cranial defect repair and promising implications for tissue engineering applications. image
Keyword ：
co-continuous structure co-continuous structure hierarchical oriented scaffolds hierarchical oriented scaffolds nanotopographical patterns nanotopographical patterns osteogenesis osteogenesis uniaxial stretching uniaxial stretching
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| GB/T 7714 | Wei, Xin , Chen, Jiaxin , Shen, Hui-Yuan et al. Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation [J]. | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (17) . |
| MLA | Wei, Xin et al. "Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation" . | ADVANCED HEALTHCARE MATERIALS 13 . 17 (2024) . |
| APA | Wei, Xin , Chen, Jiaxin , Shen, Hui-Yuan , Jiang, Kai , Ren, Haohao , Liu, Yao et al. Hierarchically Biomimetic Scaffolds with Anisotropic Micropores and Nanotopological Patterns to Promote Bone Regeneration via Geometric Modulation . | ADVANCED HEALTHCARE MATERIALS , 2024 , 13 (17) . |
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Stimuli-triggered release and alleviating resistance of iridium(III)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy. Herein, a doxorubicin@iridium-transferrin (DOX@IrTF) nanovesicle was synthesized by carboxylated-transferrin (TF) and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium (QA) groups and disulfide bonds. The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species (ROS), while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione (GSH); simultaneously, modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells. Based on in -vitro results, a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray (NIR) irradiation was presented, along with high-efficiency generation of ROS. After an intravenous injection, the nanovesicle was targeted at tumor sites, realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations. Overall, newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery, dual -stimuli responsive release, synergistic therapy strategy, and real -time monitoring. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Amphiphilic iridium complex Amphiphilic iridium complex NIR/GSH dual-responsiveness NIR/GSH dual-responsiveness Photoacoustic imaging Photoacoustic imaging Synergistic tumor therapy Synergistic tumor therapy Transferrin targeting Transferrin targeting
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| GB/T 7714 | Guo, Jinyu , Lin, Yandai , He, Shaohua et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
| MLA | Guo, Jinyu et al. "Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | CHINESE CHEMICAL LETTERS 35 . 9 (2024) . |
| APA | Guo, Jinyu , Lin, Yandai , He, Shaohua , Chen, Yueqing , Li, Fenglu , Ruan, Renjie et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
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