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学者姓名：韩霄
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Abstract ：
The development of traditional small molecule antibiotics is becoming increasingly challenging, and they are no longer effective against the growing number of multidrug-resistant infections. Therefore, in this study, polyhexamethylene biguanide-bismuth tungstate-poly(vinylpyrrolidone) nanoparticles (PHMB-BWO-PVP NPs) were synthesized to achieve effective treatment of drug-resistant bacterial infections through the synergistic chemical/low-temperature photothermal therapy (CT/LT-PTT). PHMB was loaded on BWO-PVP NPs via electrostatic interactions to form PHMB-BWO-PVP NPs that were stable in saline, phosphate-buffered saline, and Dulbecco’s modified Eagle’s medium. The NPs had a zeta potential of +10.6 mV and a particle size of about 45 nm. Moreover, the NPs were endowed with photothermal conversion ability by BWO and chemical antimicrobial capacity by PHMB. Thus, under LT-PTT, the NPs accelerated the release of PHMB, which exhibited excellent bactericidal effects against methicillin-resistant Staphylococcus aureus and drug-resistant Escherichia coli through synergistic effects, and inhibited the formation of bacterial biofilms. Importantly, PHMB-BWO-PVP NPs can eliminate skin abscesses in mice infected with drug-resistant bacteria via synergistic CT/LT-PTT, induce the transformation of M1 macrophages to M2 macrophages, promote collagen deposition and angiogenesis, and ultimately facilitate wound tissue healing. © 2024 American Chemical Society.
Keyword ：
Antibiotics Antibiotics Controlled drug delivery Controlled drug delivery Escherichia coli Escherichia coli Synthesis (chemical) Synthesis (chemical) Targeted drug delivery Targeted drug delivery Tissue regeneration Tissue regeneration
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| GB/T 7714 | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy [J]. | ACS Applied Polymer Materials , 2024 , 6 (19) : 12059-12070 . |
| MLA | Cheng, Cui et al. "Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy" . | ACS Applied Polymer Materials 6 . 19 (2024) : 12059-12070 . |
| APA | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing , Jiang, Xiwen , Lin, Ting , Han, Xiao et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy . | ACS Applied Polymer Materials , 2024 , 6 (19) , 12059-12070 . |
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Abstract ：
The development of traditional small molecule antibiotics is becoming increasingly challenging, and they are no longer effective against the growing number of multidrug-resistant infections. Therefore, in this study, polyhexamethylene biguanide-bismuth tungstate-poly(vinylpyrrolidone) nanoparticles (PHMB-BWO-PVP NPs) were synthesized to achieve effective treatment of drug-resistant bacterial infections through the synergistic chemical/low-temperature photothermal therapy (CT/LT-PTT). PHMB was loaded on BWO-PVP NPs via electrostatic interactions to form PHMB-BWO-PVP NPs that were stable in saline, phosphate-buffered saline, and Dulbecco's modified Eagle's medium. The NPs had a zeta potential of +10.6 mV and a particle size of about 45 nm. Moreover, the NPs were endowed with photothermal conversion ability by BWO and chemical antimicrobial capacity by PHMB. Thus, under LT-PTT, the NPs accelerated the release of PHMB, which exhibited excellent bactericidal effects against methicillin-resistant Staphylococcus aureus and drug-resistant Escherichia coli through synergistic effects, and inhibited the formation of bacterial biofilms. Importantly, PHMB-BWO-PVP NPs can eliminate skin abscesses in mice infected with drug-resistant bacteria via synergistic CT/LT-PTT, induce the transformation of M1 macrophages to M2 macrophages, promote collagen deposition and angiogenesis, and ultimately facilitate wound tissue healing.
Keyword ：
antidrug-resistant bacterial infection antidrug-resistant bacterial infection bismuth tungstate NPs bismuth tungstate NPs low-temperaturephotothermal therapy low-temperaturephotothermal therapy PHMB PHMB synergistic antimicrobial synergistic antimicrobial
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| GB/T 7714 | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy [J]. | ACS APPLIED POLYMER MATERIALS , 2024 , 6 (19) : 12059-12070 . |
| MLA | Cheng, Cui et al. "Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy" . | ACS APPLIED POLYMER MATERIALS 6 . 19 (2024) : 12059-12070 . |
| APA | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing , Jiang, Xiwen , Lin, Ting , Han, Xiao et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy . | ACS APPLIED POLYMER MATERIALS , 2024 , 6 (19) , 12059-12070 . |
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| GB/T 7714 | Li, Xiaojun , Uslu, Veli Vural , Chen, Ying et al. Specific chromatin states and m6A modifications are associated with mRNA mobility in planta [J]. | HORTICULTURE RESEARCH , 2024 , 11 (6) . |
| MLA | Li, Xiaojun et al. "Specific chromatin states and m6A modifications are associated with mRNA mobility in planta" . | HORTICULTURE RESEARCH 11 . 6 (2024) . |
| APA | Li, Xiaojun , Uslu, Veli Vural , Chen, Ying , Han, Xiao , Berr, Alexandre , Zhang, Wenna et al. Specific chromatin states and m6A modifications are associated with mRNA mobility in planta . | HORTICULTURE RESEARCH , 2024 , 11 (6) . |
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Aim: Type 2 diabetes mellitus (T2DM) is one of the most common diseases, and epigenetic modification N6-methyladenosine (m(6)A) is essential for transcriptional modulation involved in its development. However, the precise role and landscape of transcriptome-wide m(6)A alterations in molecular adaptations after physical exercise have yet to be fully elucidated. Methods: Four-week-old male C57BL/6J mice received a high-fat diet (HFD) for 12 weeks to establish a diabetic state, and HFD mice were simultaneously subjected to physical exercise (HFD + EX). The hepatic RNA m(6)A methylome was examined, the conjoint MeRIP-seq and RNA-seq was performed, and the exercise-modulated genes were confirmed. Results: Physical exercise significantly ameliorates liver metabolic disorder and triggers a dynamic change in hepatic RNA m(6)A. By analyzing the distribution of m(6)A in transcriptomes, an abundance of m(6)A throughout mRNA transcripts and a pattern of conserved m(6)A after physical exercise was identified. It is noteworthy that conjoint MeRIP-seq and RNA-seq data revealed that both differentially methylated genes and differentially expressed genes were enriched in all stages of the PI3K-Akt signaling pathway, in particular the upstream nodes of this pathway, which are considered a valuable therapeutic target for T2DM. Moreover, in vivo and in vitro analyses showed that exercise-mediated methyltransferase Rbm15 positively regulated the expression of two upstream genes (Itga3 and Fgf21) in an m(6)A-dependent manner. Conclusion: These findings highlight the pivotal role of the exercise-induced m(6)A epigenetic network and contribute insights into the intricate epigenetic mechanism underlying insulin signaling.
Keyword ：
PI3K-Akt signaling PI3K-Akt signaling RNA m(6)A modification RNA m(6)A modification transcriptome transcriptome type 2 diabetes mellitus type 2 diabetes mellitus
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| GB/T 7714 | Cong, Chen , Jiang, Cai , Lin, Ting et al. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise [J]. | ACTA PHYSIOLOGICA , 2024 , 240 (6) . |
| MLA | Cong, Chen et al. "Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise" . | ACTA PHYSIOLOGICA 240 . 6 (2024) . |
| APA | Cong, Chen , Jiang, Cai , Lin, Ting , Hu, Yue , Wu, Huijuan , Xiang, Qing et al. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise . | ACTA PHYSIOLOGICA , 2024 , 240 (6) . |
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The immune system plays a crucial role in the ageing process. As individuals age, significant alterations in the immune system experiences occur, marked by a decline in immune cell count, compromised immune function, and decreased immune regulation across various immune organs. These changes collectively weaken the capacity to combat diseases and infections, highlighting the vulnerability that accompanies ageing. Exercise is a potent intervention that profoundly influences holistic well-being and disease mitigation, with a notable emphasis on immune modulation. In general, regular moderate exercise holds significant potential to enhance immune defense mechanisms and metabolic well-being by augmenting the circulation and activation of immune cells. However, some exercise modalities would trigger detrimental effects on the immune system. It can be seen that the regulatory responses of various immune organs to diverse exercise patterns are different. This review aims to examine the immunological responses elicited by exercise across various immune organs, including the lymph nodes, spleen, bone marrow, and thymus, to underscore the nuanced interplay between exercise patterns and the immune organ. This underscores the importance of customizing exercise interventions to optimize immune function across the lifespan.
Keyword ：
Ageing Ageing Exercise Exercise Immune organs Immune organs Immune response Immune response
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| GB/T 7714 | Zhou, Huanghao , Han, Xiao , Huang, Chunxiu et al. Exercise-induced adaptive response of different immune organs during ageing [J]. | AGEING RESEARCH REVIEWS , 2024 , 102 . |
| MLA | Zhou, Huanghao et al. "Exercise-induced adaptive response of different immune organs during ageing" . | AGEING RESEARCH REVIEWS 102 (2024) . |
| APA | Zhou, Huanghao , Han, Xiao , Huang, Chunxiu , Wu, Huijuan , Hu, Yue , Chen, Cong et al. Exercise-induced adaptive response of different immune organs during ageing . | AGEING RESEARCH REVIEWS , 2024 , 102 . |
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Signal amplification and noise reduction are very crucial for the sensitive determination of disease-related biomarkers. The development of rapid and laborious testing is urgently required due to extended incubation time and high mortality. Herein, we developed a Ce-based mesoporous metal-organic framework-based multi-enzyme encapsulation device for the realization of enzyme-linked immunosorbent assay (ELISA) for the dengue virus (DENV). Briefly, a UiO-66(Ce) framework structure with uniform mesopores was synthesized by a one-pot method, which allowed efficient encapsulation of natural enzymes with an encapsulation efficiency of 700%. The developed multi-enzyme reaction probes were able to maintain more than 90% of catalytic activity stable at room temperature for 60 days while ensuring efficient enzyme immobilization. Sensitive evaluation of DENV was achieved by encapsulating glucose oxidase and horseradish peroxidase, combined with the formation of an immune sandwich in the presence of DENV. The developed sensor enabled flexible detection of recombinant dengue virus serotype 2 NS1 protein (DENV2-NS1) from 0.05 to 100 ng mL-1, with a low limit of detection of 39.7 pg mL-1. In addition, there were no significant differences in the test results of the samples obtained through the developed multi-enzyme probes when compared to commercially available ELISA kits. This work provides new horizons for the development of efficient enzyme encapsulation systems.
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| GB/T 7714 | Lin, Luanfeng , Fan, Xiangqun , Yan, Yinmei et al. In situ amplified colorimetric immunoassay coupled with a dual-enzyme-functionalized UiO-66(Ce) framework for quantitative detection of the dengue virus [J]. | SENSORS & DIAGNOSTICS , 2024 , 4 (1) : 75-81 . |
| MLA | Lin, Luanfeng et al. "In situ amplified colorimetric immunoassay coupled with a dual-enzyme-functionalized UiO-66(Ce) framework for quantitative detection of the dengue virus" . | SENSORS & DIAGNOSTICS 4 . 1 (2024) : 75-81 . |
| APA | Lin, Luanfeng , Fan, Xiangqun , Yan, Yinmei , Lin, Ting , Han, Xiao , Tang, Dianping et al. In situ amplified colorimetric immunoassay coupled with a dual-enzyme-functionalized UiO-66(Ce) framework for quantitative detection of the dengue virus . | SENSORS & DIAGNOSTICS , 2024 , 4 (1) , 75-81 . |
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Methods derived from photoelectrochemical (PEC) have been constructed for immunoassays, but most involve the split-type immunoreaction modes, and thus easily cause unpredictable intermediate precision. Herein, we innovatively designed an integrated PEC immunosensing platform for the quantitative monitoring of thyro-globulin (TG) on the gold nanoparticles (AuNPs)-functionalized BiVO4 photoanode coupling with enzymatic biocatalytic precipitation (EBCP). This sensing system could simultaneously implement the immunoreaction and photocurrent measurement. Anti-TG capture antibodies were modified onto AuNPs-decorated BiVO4 photo -electrode. A sandwich-type immunoreaction was carried out in the presence of target TG using horseradish peroxidase (HRP)-conjugated anti-TG detection antibody. The carried HRP molecules catalyzed 4-chloro-1-naph-thol (4-CN) to generate an insoluble benzo-4-chlorohexadienone product on the photoanode in the presence of peroxide hydrogen, thereby decreasing the photocurrent. Under optimal conditions, the PEC immunosensors gave good photocurrent responses toward target TG within the dynamic range of 0.01-10 ng mL-1 at a detection limit of 7.6 pg mL-1. Good repeatability and precision, high specificity and acceptable storage stability were acquired during the measurement. No significant differences were encountered for screening 15 human serum specimens between the developed PEC immunoassay and commercially available enzyme-linked immunosorbent assay (ELISA) method for the detection of target TG. Significantly, PEC immunosensing system offers promise for simple and cost-effective analysis of disease-related biomarkers.
Keyword ：
BiVO4 photoactive materials BiVO4 photoactive materials Enzymatic biocatalytic precipitation Enzymatic biocatalytic precipitation Gold nanoparticles Gold nanoparticles Photoanode Photoanode Photoelectrochemical immunoassay Photoelectrochemical immunoassay Thyroglobulin Thyroglobulin
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| GB/T 7714 | Jiang, Xiwen , Pan, Cuiyuan , Wang, Qiaowen et al. Photoelectrochemical immunoassay for thyroglobulin on nanogold-functionalized BiVO4 photoanode coupling with enzymatic biocatalytic precipitation [J]. | ANALYTICA CHIMICA ACTA , 2023 , 1239 . |
| MLA | Jiang, Xiwen et al. "Photoelectrochemical immunoassay for thyroglobulin on nanogold-functionalized BiVO4 photoanode coupling with enzymatic biocatalytic precipitation" . | ANALYTICA CHIMICA ACTA 1239 (2023) . |
| APA | Jiang, Xiwen , Pan, Cuiyuan , Wang, Qiaowen , Han, Xiao , Tang, Dianping . Photoelectrochemical immunoassay for thyroglobulin on nanogold-functionalized BiVO4 photoanode coupling with enzymatic biocatalytic precipitation . | ANALYTICA CHIMICA ACTA , 2023 , 1239 . |
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As an internal modification of transcripts, RNA methylation determines RNA fate by changing RNA-protein binding affinity. In plants, RNA methylation is ubiquitous and is involved in all aspects of RNA post-transcriptional regulation. For instance, long-distance mobile RNAs, strongly influenced by their methylation status, play important roles in plant growth, development and environmental adaptation. Cucumber/ pumpkin heterografts are widely used to improve stress tolerance of cucumber and to study mobile RNA signals due to their strong developed vasculature system. Here, we developed the Cucume (Cucurbit RNA methylation, http://cucume.cn/) database for these two important vegetables, cucumber (Cucumis sativus L.) and pumpkin (Cucurbita moschata) with high productivity worldwide. We identified mRNAs harboring 5methylcytosine (m5C) and N6-methyladenosine (m6A) sites in pumpkin and cucumber at the whole genome level via Methylated RNA Immunoprecipitation sequencing (MeRIP-seq) of different tissues and the vascular exudates. In addition to RNA methylation sites, the Cucume database includes graft-transmissible systemic mRNAs identified in previous studies using cucumber/pumpkin heterografts. The further integration of cucumber genome-wide association analysis (GWAS) and quantitative trait loci (QTL) allows the study of RNA methylation-related genetic and epigenetic regulation in cucurbits. Therefore, the here developed Cucume database will promote understanding the role of cucurbit RNA methylation in RNA mobility and QTL, ultimately benefitting future breeding of agronomic crop germplasms.(c) 2023 China Agricultural University. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
Graft -transmissible mRNA Graft -transmissible mRNA QTL QTL RNA methylation RNA methylation RNA motifs RNA motifs
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| GB/T 7714 | Li, Xiaojun , Lin, Shujin , Xiang, Chenggang et al. CUCUME: An RNA methylation database integrating systemic mRNAs signals, GWAS and QTL genetic regulation and epigenetics in different tissues of Cucurbitaceae [J]. | COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL , 2023 , 21 : 837-846 . |
| MLA | Li, Xiaojun et al. "CUCUME: An RNA methylation database integrating systemic mRNAs signals, GWAS and QTL genetic regulation and epigenetics in different tissues of Cucurbitaceae" . | COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 21 (2023) : 837-846 . |
| APA | Li, Xiaojun , Lin, Shujin , Xiang, Chenggang , Liu, Wenqian , Zhang, Xiaojing , Wang, Cuicui et al. CUCUME: An RNA methylation database integrating systemic mRNAs signals, GWAS and QTL genetic regulation and epigenetics in different tissues of Cucurbitaceae . | COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL , 2023 , 21 , 837-846 . |
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High concentrations of heavy metals in the environment will cause serious harm to ecosystems and human health. It is urgent to develop effective methods to control soil heavy metal pollution. Phytoremediation has advantages and potential for soil heavy metal pollution control. However, the current hyperaccumulators have the disadvantages of poor environmental adaptability, single enrichment species and small biomass. Based on the concept of modularity, synthetic biology makes it possible to design a wide range of organisms. In this paper, a comprehensive strategy of "microbial biosensor detection - phytoremediation - heavy metal recovery" for soil heavy metal pollution control was proposed, and the required steps were modified by using synthetic biology methods. This paper summarizes the new experimental methods that promote the discovery of synthetic biological elements and the construction of circuits, and combs the methods of producing transgenic plants to facilitate the transformation of constructed synthetic biological vectors. Finally, the problems that should be paid more attention to in the remediation of soil heavy metal pollution based on synthetic biology were discussed.
Keyword ：
heavy metal heavy metal phytoremediation phytoremediation root root shoot shoot soil soil
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| GB/T 7714 | Bai, Shiyan , Han, Xiao , Feng, Dan . Shoot-root signal circuit: Phytoremediation of heavy metal contaminated soil [J]. | FRONTIERS IN PLANT SCIENCE , 2023 , 14 . |
| MLA | Bai, Shiyan et al. "Shoot-root signal circuit: Phytoremediation of heavy metal contaminated soil" . | FRONTIERS IN PLANT SCIENCE 14 (2023) . |
| APA | Bai, Shiyan , Han, Xiao , Feng, Dan . Shoot-root signal circuit: Phytoremediation of heavy metal contaminated soil . | FRONTIERS IN PLANT SCIENCE , 2023 , 14 . |
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Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be associated with CVD development. However, the beneficial effects of healthy microbiota in decreasing cholesterol levels have not been summarized. Herein, we begin by discussing the potential mechanisms by which the gut microbiota reduces cholesterol levels. We further sketch the application of probiotics from the genera Lactobacillus and Bifidobacterium in reducing cholesterol levels in clinical studies. Finally, we present the cholesterol-lowering function of beneficial commensal microbes, such as Akkermansia and Bacteroides spp., as these microbes have potential to be the next-generation probiotics (NGPs). The information reviewed in this paper will help people to understand how the gut microbiome might alter cholesterol metabolism and enable the development of NGPs to prevent and treat CVD.
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| GB/T 7714 | Jia, Baolei , Zou, Yuanqiang , Han, Xiao et al. Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease [J]. | TRENDS IN MICROBIOLOGY , 2023 , 31 (1) : 76-91 . |
| MLA | Jia, Baolei et al. "Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease" . | TRENDS IN MICROBIOLOGY 31 . 1 (2023) : 76-91 . |
| APA | Jia, Baolei , Zou, Yuanqiang , Han, Xiao , Bae, Jin-Woo , Jeon, Che Ok . Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease . | TRENDS IN MICROBIOLOGY , 2023 , 31 (1) , 76-91 . |
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