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学者姓名：韩霄
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Abstract ：
RNA interference (RNAi) has been widely used in agriculture. However, it is well accepted that common methods of plant RNAi are species-dependent and lack systematic efficiency. This study designed a thiolated siRNA nanoparticle, guanidinium (Gu+)-containing disulfide assembled siRNA (Gu+-siRNA), demonstrating remarkable species independence and efficient systemic gene silencing across different plant species. Our results indicate that this approach effectively utilizes the plant vascular system to deliver siRNA, enabling long-distance gene silencing across both monocot and dicot plants, such as rice and Arabidopsis. By applying this method, we successfully targeted and silenced key genes like STM, WER, MYB23, GD1, EIL1, and EIL2, which regulate plant development and enhance salt tolerance. This delivery system significantly expands the application of RNAi technology across different plants, serving as a valuable tool for advancing agricultural biotechnology, enhancing crop resistance, and improving agricultural productivity, while aligning with global goals for sustainable food production and crop improvement.
Keyword ：
long-distance movement long-distance movement nanoparticle nanoparticle RNA interference RNA interference systematically deliver systematically deliver thiolated thiolated
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| GB/T 7714 | Lin, Shujin , Zhang, Qian , Bai, Shiyan et al. Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles [J]. | PLANT BIOTECHNOLOGY JOURNAL , 2025 , 23 (4) : 1165-1177 . |
| MLA | Lin, Shujin et al. "Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles" . | PLANT BIOTECHNOLOGY JOURNAL 23 . 4 (2025) : 1165-1177 . |
| APA | Lin, Shujin , Zhang, Qian , Bai, Shiyan , Yang, Liwen , Qin, Guannan , Wang, Liyuan et al. Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles . | PLANT BIOTECHNOLOGY JOURNAL , 2025 , 23 (4) , 1165-1177 . |
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A new nanoparticles-based sensing platform was designed for high-through electrochemical immunoassay of ferritin (FET) biomarker on a magneto-controlled microfluidic device by using anti-FET capture antibody-conjugated magnetic sensing probes. Thionine-doped calcium carbonate (CaCO3) nanoparticles labeled with anti-FET detection antibodies were utilized as the recognition elements. Introduction of target FET caused the sandwich-type immunoreaction between two antibodies. The formed immunocomplexes were attached onto magnetic microfluidic sensing interface through an external magnet. Subsequently, the carried CaCO3 nanoparticles were dissolved under acidic conditions to release the doped thionine molecules with redox activity. The thionine-based voltammetric signals increased with the increment of target FET levels within the linear range 0.01-100 ng mL-1. The limit of detection was 7.9 pg mL-1 FET. Good analytical properties such as selectivity, reproducibility, and accuracy were achieved with the nanoparticles-based magnetic electrochemical immunoassay. More significantly, the magnetic microfluidic electrochemical immunoassay provides new opportunities for rapid, simple, and cost-effective serum sample analysis.
Keyword ：
Calcium carbonate with redox activity Calcium carbonate with redox activity Electrochemical immunoassay Electrochemical immunoassay Ferritin biomarker Ferritin biomarker High-throughput analysis High-throughput analysis Magnetic beads Magnetic beads Magnetic microfluidic device Magnetic microfluidic device Square-wave voltammetry Square-wave voltammetry
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| GB/T 7714 | Lin, Shaofeng , Lin, Ting , Xu, Haipeng et al. Nanoparticles-based electrochemical sensing platform for high-through immunoassay with redox-activity CaCO3 nanotags on a magnetic microfluidic device [J]. | MICROCHIMICA ACTA , 2025 , 192 (5) . |
| MLA | Lin, Shaofeng et al. "Nanoparticles-based electrochemical sensing platform for high-through immunoassay with redox-activity CaCO3 nanotags on a magnetic microfluidic device" . | MICROCHIMICA ACTA 192 . 5 (2025) . |
| APA | Lin, Shaofeng , Lin, Ting , Xu, Haipeng , Li, Haining , Zhang, Wenwen , Wu, Chenyu et al. Nanoparticles-based electrochemical sensing platform for high-through immunoassay with redox-activity CaCO3 nanotags on a magnetic microfluidic device . | MICROCHIMICA ACTA , 2025 , 192 (5) . |
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Aim: Type 2 diabetes mellitus (T2DM) is one of the most common diseases, and epigenetic modification N6-methyladenosine (m(6)A) is essential for transcriptional modulation involved in its development. However, the precise role and landscape of transcriptome-wide m(6)A alterations in molecular adaptations after physical exercise have yet to be fully elucidated. Methods: Four-week-old male C57BL/6J mice received a high-fat diet (HFD) for 12 weeks to establish a diabetic state, and HFD mice were simultaneously subjected to physical exercise (HFD + EX). The hepatic RNA m(6)A methylome was examined, the conjoint MeRIP-seq and RNA-seq was performed, and the exercise-modulated genes were confirmed. Results: Physical exercise significantly ameliorates liver metabolic disorder and triggers a dynamic change in hepatic RNA m(6)A. By analyzing the distribution of m(6)A in transcriptomes, an abundance of m(6)A throughout mRNA transcripts and a pattern of conserved m(6)A after physical exercise was identified. It is noteworthy that conjoint MeRIP-seq and RNA-seq data revealed that both differentially methylated genes and differentially expressed genes were enriched in all stages of the PI3K-Akt signaling pathway, in particular the upstream nodes of this pathway, which are considered a valuable therapeutic target for T2DM. Moreover, in vivo and in vitro analyses showed that exercise-mediated methyltransferase Rbm15 positively regulated the expression of two upstream genes (Itga3 and Fgf21) in an m(6)A-dependent manner. Conclusion: These findings highlight the pivotal role of the exercise-induced m(6)A epigenetic network and contribute insights into the intricate epigenetic mechanism underlying insulin signaling.
Keyword ：
PI3K-Akt signaling PI3K-Akt signaling RNA m(6)A modification RNA m(6)A modification transcriptome transcriptome type 2 diabetes mellitus type 2 diabetes mellitus
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| GB/T 7714 | Cong, Chen , Jiang, Cai , Lin, Ting et al. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise [J]. | ACTA PHYSIOLOGICA , 2024 , 240 (6) . |
| MLA | Cong, Chen et al. "Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise" . | ACTA PHYSIOLOGICA 240 . 6 (2024) . |
| APA | Cong, Chen , Jiang, Cai , Lin, Ting , Hu, Yue , Wu, Huijuan , Xiang, Qing et al. Landscape of transcriptome-wide m6A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise . | ACTA PHYSIOLOGICA , 2024 , 240 (6) . |
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The immune system plays a crucial role in the ageing process. As individuals age, significant alterations in the immune system experiences occur, marked by a decline in immune cell count, compromised immune function, and decreased immune regulation across various immune organs. These changes collectively weaken the capacity to combat diseases and infections, highlighting the vulnerability that accompanies ageing. Exercise is a potent intervention that profoundly influences holistic well-being and disease mitigation, with a notable emphasis on immune modulation. In general, regular moderate exercise holds significant potential to enhance immune defense mechanisms and metabolic well-being by augmenting the circulation and activation of immune cells. However, some exercise modalities would trigger detrimental effects on the immune system. It can be seen that the regulatory responses of various immune organs to diverse exercise patterns are different. This review aims to examine the immunological responses elicited by exercise across various immune organs, including the lymph nodes, spleen, bone marrow, and thymus, to underscore the nuanced interplay between exercise patterns and the immune organ. This underscores the importance of customizing exercise interventions to optimize immune function across the lifespan.
Keyword ：
Ageing Ageing Exercise Exercise Immune organs Immune organs Immune response Immune response
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| GB/T 7714 | Zhou, Huanghao , Han, Xiao , Huang, Chunxiu et al. Exercise-induced adaptive response of different immune organs during ageing [J]. | AGEING RESEARCH REVIEWS , 2024 , 102 . |
| MLA | Zhou, Huanghao et al. "Exercise-induced adaptive response of different immune organs during ageing" . | AGEING RESEARCH REVIEWS 102 (2024) . |
| APA | Zhou, Huanghao , Han, Xiao , Huang, Chunxiu , Wu, Huijuan , Hu, Yue , Chen, Cong et al. Exercise-induced adaptive response of different immune organs during ageing . | AGEING RESEARCH REVIEWS , 2024 , 102 . |
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| GB/T 7714 | Li, Xiaojun , Uslu, Veli Vural , Chen, Ying et al. Specific chromatin states and m6A modifications are associated with mRNA mobility in planta [J]. | HORTICULTURE RESEARCH , 2024 , 11 (6) . |
| MLA | Li, Xiaojun et al. "Specific chromatin states and m6A modifications are associated with mRNA mobility in planta" . | HORTICULTURE RESEARCH 11 . 6 (2024) . |
| APA | Li, Xiaojun , Uslu, Veli Vural , Chen, Ying , Han, Xiao , Berr, Alexandre , Zhang, Wenna et al. Specific chromatin states and m6A modifications are associated with mRNA mobility in planta . | HORTICULTURE RESEARCH , 2024 , 11 (6) . |
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The development of traditional small molecule antibiotics is becoming increasingly challenging, and they are no longer effective against the growing number of multidrug-resistant infections. Therefore, in this study, polyhexamethylene biguanide-bismuth tungstate-poly(vinylpyrrolidone) nanoparticles (PHMB-BWO-PVP NPs) were synthesized to achieve effective treatment of drug-resistant bacterial infections through the synergistic chemical/low-temperature photothermal therapy (CT/LT-PTT). PHMB was loaded on BWO-PVP NPs via electrostatic interactions to form PHMB-BWO-PVP NPs that were stable in saline, phosphate-buffered saline, and Dulbecco's modified Eagle's medium. The NPs had a zeta potential of +10.6 mV and a particle size of about 45 nm. Moreover, the NPs were endowed with photothermal conversion ability by BWO and chemical antimicrobial capacity by PHMB. Thus, under LT-PTT, the NPs accelerated the release of PHMB, which exhibited excellent bactericidal effects against methicillin-resistant Staphylococcus aureus and drug-resistant Escherichia coli through synergistic effects, and inhibited the formation of bacterial biofilms. Importantly, PHMB-BWO-PVP NPs can eliminate skin abscesses in mice infected with drug-resistant bacteria via synergistic CT/LT-PTT, induce the transformation of M1 macrophages to M2 macrophages, promote collagen deposition and angiogenesis, and ultimately facilitate wound tissue healing.
Keyword ：
antidrug-resistant bacterial infection antidrug-resistant bacterial infection bismuth tungstate NPs bismuth tungstate NPs low-temperaturephotothermal therapy low-temperaturephotothermal therapy PHMB PHMB synergistic antimicrobial synergistic antimicrobial
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| GB/T 7714 | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy [J]. | ACS APPLIED POLYMER MATERIALS , 2024 , 6 (19) : 12059-12070 . |
| MLA | Cheng, Cui et al. "Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy" . | ACS APPLIED POLYMER MATERIALS 6 . 19 (2024) : 12059-12070 . |
| APA | Cheng, Cui , Cheng, Jianwen , Feng, Wenjing , Jiang, Xiwen , Lin, Ting , Han, Xiao et al. Bismuth Tungstate-Based Nanoparticles Promoting Healing of Drug-Resistant Bacteria Infected Abscesses by Chemical/Low-Temperature Photothermal Therapy . | ACS APPLIED POLYMER MATERIALS , 2024 , 6 (19) , 12059-12070 . |
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In eukaryotic cells, epigenetic modifications of DNA and histone play an important role in the regulation of gene expression. ROXY19 is a member of the plant specific CC-type glutaredoxins (GRXs). We found previously that ROXY19, by association with the TOPLESS/TOPLESS-related (TPL/TPR) family, strongly repressed a subset of genes which were positively regulated by the class II TGA factors. Arabidopsis plants ectopic expressing ROXY19 (ROXY19OE) were hypersensitive to xenobiotic chemicals due to the silencing of detoxification pathway genes. Here, we confirmed in vivo the interaction between ROXY19 and TPL. In order to understand the molecular mechanism underlying ROXY19-TPL module mediated gene repression, DNA methylation and histone deacetylation inhibitors were applied to assess the involvement of epigenetic modifications in the silencing of detoxification pathway genes in ROXY19OE plants. Promoter regions of some ROXY19 repressed genes were not methylated in wild-type/Col-0, and the methylation status were not altered in ROXY19OE. Furthermore, we investigated the role of epigenetic modifications in the antagonistic interplay between ethylene/jasmonic acid (ET/JA) and salicylic acid (SA) signaling pathways, which were supposed to be regulated by ROXY19.
Keyword ：
Epigenetics Epigenetics Gene expression Gene expression Glutaredoxin Glutaredoxin Plant hormone Plant hormone Xenobiotic detoxification Xenobiotic detoxification
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| GB/T 7714 | Li, Ning , Yu, Peiyao , Zeng, Yanling et al. Characterization of epigenetic modifications in a plant-specific glutaredoxin-mediated repression of stress-responsive gene expression [J]. | ENVIRONMENTAL AND EXPERIMENTAL BOTANY , 2023 , 217 . |
| MLA | Li, Ning et al. "Characterization of epigenetic modifications in a plant-specific glutaredoxin-mediated repression of stress-responsive gene expression" . | ENVIRONMENTAL AND EXPERIMENTAL BOTANY 217 (2023) . |
| APA | Li, Ning , Yu, Peiyao , Zeng, Yanling , Chen, Jiali , Yang, Wenhai , Qin, Guannan et al. Characterization of epigenetic modifications in a plant-specific glutaredoxin-mediated repression of stress-responsive gene expression . | ENVIRONMENTAL AND EXPERIMENTAL BOTANY , 2023 , 217 . |
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Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be associated with CVD development. However, the beneficial effects of healthy microbiota in decreasing cholesterol levels have not been summarized. Herein, we begin by discussing the potential mechanisms by which the gut microbiota reduces cholesterol levels. We further sketch the application of probiotics from the genera Lactobacillus and Bifidobacterium in reducing cholesterol levels in clinical studies. Finally, we present the cholesterol-lowering function of beneficial commensal microbes, such as Akkermansia and Bacteroides spp., as these microbes have potential to be the next-generation probiotics (NGPs). The information reviewed in this paper will help people to understand how the gut microbiome might alter cholesterol metabolism and enable the development of NGPs to prevent and treat CVD.
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| GB/T 7714 | Jia, Baolei , Zou, Yuanqiang , Han, Xiao et al. Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease [J]. | TRENDS IN MICROBIOLOGY , 2023 , 31 (1) : 76-91 . |
| MLA | Jia, Baolei et al. "Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease" . | TRENDS IN MICROBIOLOGY 31 . 1 (2023) : 76-91 . |
| APA | Jia, Baolei , Zou, Yuanqiang , Han, Xiao , Bae, Jin-Woo , Jeon, Che Ok . Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease . | TRENDS IN MICROBIOLOGY , 2023 , 31 (1) , 76-91 . |
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Objective: Using meta-analysis, we evaluate circulating tumor cells(CTCs) as a potential diagnostic tool for breast cancer.Methods A document search was conducted using publicly available databases up to May 2021. Specific inclusion and exclusion criteria were formulated and summarize relevant data through literature types, research types, case populations, samples, etc. Subgroup analysis of documents based on regions, enrichment methods, and detection methods. The included research projects were evaluated using DeeKs' bias, and evaluation indicators such as specificity (SPE), sensitivity (SEN), diagnosis odds ratio (DOR) were used as evaluation indicators.Results: 16 studies on the use of circulating tumor cells to diagnose breast cancer were included in our meta-analysis. Overall sensitivity value was 0.50 (95%CI:0.48-0.52), specificity value was 0.93 (95%CI:0.92- 0.95), DOR value was 33.41 (95%CI:12.47-89.51), and AUC value was 0.8129.Conclusion:bIn meta-regressions and subgroup analysis, potential heterogeneity factors were analyzed, but the source of heterogeneity is still unclear. CTCs, as a novel tumor marker, have a good diagnostic value, but its enrichment and detection methods still need to continue to be developed to improve detection accuracy. Therefore, CTCs can be used as an auxiliary means of early detection, which is helpful to the diagnosis and screening of breast cancer.
Keyword ：
breast cancer breast cancer circulating tumor cells circulating tumor cells diagnostic diagnostic liquid biopsy liquid biopsy meta-analysis meta-analysis
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| GB/T 7714 | Bai, Shiyan , Lin, Shujin , Lin, Ting et al. Clinical diagnostic biomarker "circulating tumor cells" in breast cancer - a meta-analysis [J]. | FRONTIERS IN ONCOLOGY , 2023 , 13 . |
| MLA | Bai, Shiyan et al. "Clinical diagnostic biomarker "circulating tumor cells" in breast cancer - a meta-analysis" . | FRONTIERS IN ONCOLOGY 13 (2023) . |
| APA | Bai, Shiyan , Lin, Shujin , Lin, Ting , Wang, Qiaowen , Cheng, Cui , Lin, Junru et al. Clinical diagnostic biomarker "circulating tumor cells" in breast cancer - a meta-analysis . | FRONTIERS IN ONCOLOGY , 2023 , 13 . |
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Diabetic foot (DF) is difficult to heal due to the formation of drug-resistant bacterial biofilms and dysregulation of the wound microenvironment. To solve this problem, multifunctional hydrogels were prepared by in situ or spraying with 3-aminophenylboronic acid modified oxidized chondroitin sulfate (APBA-g-OCS), polyvinyl alcohol (PVA) and black phosphorus/bismuth oxide/e-polylysine (BP/Bi2O3/e-PL) as precursors for promoting infected diabetic wounds healing. The hydrogels display multiple stimulus responsiveness, strong adhesion and rapid self-healing ability owing to the dynamic borate ester bonds, hydrogen bonds and 7C-7C conjugation crosslink points, remain synergistic chemo-photothermal antibacterial effect and anti-biofilm formation ability due to the doping of BP/ Bi2O3/e-PL into the hydrogel by dynamic imine bonds crosslinking and possess antioxidation and inflammatory chemokine adsorption ability attributing to the presence of APBA-g-OCS. Most importantly, as a result of the above functions, the hydrogels can not only respond to the wound microenvironment to conduct combined PTT and chemotherapy for efficient anti-inflammation, but also improve the wound microenvironment by scavenging ROS and regulating the expression of cytokines, thus further accelerating collagen deposition, promoting granulation tissue formation and angiogenesis, finally promoting the healing of infected wounds in diabetic rats.
Keyword ：
Combined PTT and chemotherapy Combined PTT and chemotherapy Diabetic foot Diabetic foot Inflammatory chemokine adsorption Inflammatory chemokine adsorption Multifunctional hydrogel Multifunctional hydrogel Wounds healing Wounds healing
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| GB/T 7714 | Zhang, Yuan , Chen, Wenjuan , Feng, Wenjing et al. Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation [J]. | CARBOHYDRATE POLYMERS , 2023 , 314 . |
| MLA | Zhang, Yuan et al. "Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation" . | CARBOHYDRATE POLYMERS 314 (2023) . |
| APA | Zhang, Yuan , Chen, Wenjuan , Feng, Wenjing , Fang, Wenhong , Han, Xiao , Cheng, Cui . Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation . | CARBOHYDRATE POLYMERS , 2023 , 314 . |
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