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学者姓名:陈岚岚
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Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective and personalized cancer treatments. However, the requirement of high doses of X-ray irradiation to break chemical bonds for drug release limits the application of radiotherapy-induced prodrug activation in clinics. Recent advances in nanomaterials offer a promising approach for radiotherapy sensitization as well as integrating multiple modalities for improved therapy outcomes. In particular, the catalytic radiosensitization that utilizes electrons and energy generated by nanomaterials upon X-ray irradiation has demonstrated excellent potential for enhanced radiotherapy. In this Review, we summarize the design principles of X-ray-responsive chemical bonds for controlled drug release, strategies for catalytic radiosensitization, and recent progress of X-ray-responsive nanoradiosensitizers for enhanced radiotherapy by integration with chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, gas therapy, and immunotherapy. Finally, we discuss the challenges of X-ray-responsive nanoradiosensitizers heading toward possible clinical translation. We expect that emerging strategies based on radiotherapy-triggered drug release will facilitate a frontier in accurate and effective cancer therapy in the near future.
Keyword :
combined therapy combined therapy nanomaterials nanomaterials radiosensitive radiosensitive radiotherapy radiotherapy X-ray responsivedrug release X-ray responsivedrug release
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GB/T 7714 | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun et al. Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release [J]. | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) : 14801-14821 . |
MLA | Jiang, Renfeng et al. "Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release" . | ACS APPLIED MATERIALS & INTERFACES 17 . 10 (2025) : 14801-14821 . |
APA | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun , Chen, Lanlan , Yang, Huanghao . Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release . | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) , 14801-14821 . |
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Evaluating tumor radiosensitivity is beneficial for the prediction of treatment efficacy, customization of treatment plans, and minimization of side effects. Tracking the mitochondrial DNA (mtDNA) repair process helps to assess tumor radiosensitivity as mtDNA repair determines the fate of the cell under radiation-induced mtDNA damage. However, current probes developed to monitor levels of DNA repair enzymes suffered from complex synthesis, uncontrollable preparation, limited tumor selectivity, and poor organelle-targeting ability. Especially, the correlation between mtDNA repair activity and inherent radiosensitivity of tumors has not yet been explored. Here, we present a mitochondria-targeted DNA-based nanoprobe (TPP-Apt-tFNA) for in situ monitoring of the activity of the mtDNA repair enzyme and evaluating tumor radiosensitivity. TPP-Apt-tFNA consists of a DNA tetrahedral framework precisely modified with three functional modules on each of the three vertexes, that is, the tumor cell-targeting aptamer, the mitochondrion-targeting moiety, and the apurinic/apyrimidinic endonuclease 1 (APE1)-responsive molecule beacon. Once selectively internalized by tumor cells, the nanoprobe targeted the mitochondrion and specifically recognized APE1 to activate fluorescence, allowing the observation of mtDNA repair activity. The nanoprobe showed elevated APE1 levels in the mitochondria of tumor cells under oxidative stress. Moreover, the nanoprobe enabled the illumination of different levels of APE1-mediated mtDNA repair activity in different cell cycle phases. Furthermore, using the nanoprobe in vitro and in vivo, we found that tumor cells with high activity of mtDNA repair, which allowed them to recover from radiation-induced mtDNA lesions, had low sensitivity to radiation and an unsatisfactory radiotherapy outcome. Our work provides a new imaging tool for exploring the roles of mtDNA repair activity in diverse biological processes and for guiding tumor radiation treatment.
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GB/T 7714 | Chen, Lanlan , Lai, Jingjing , Dong, Siqi et al. Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (1) : 382-391 . |
MLA | Chen, Lanlan et al. "Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity" . | ANALYTICAL CHEMISTRY 97 . 1 (2025) : 382-391 . |
APA | Chen, Lanlan , Lai, Jingjing , Dong, Siqi , Liu, Wenjun , Zhang, Ximei , Yang, Huanghao . Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity . | ANALYTICAL CHEMISTRY , 2025 , 97 (1) , 382-391 . |
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Accurate differentiation of benign and malignant breast tumors is paramount for establishing schemes of breast cancer treatment and prognosis. Here we report a near-infrared (NIR) fluorescence probe (YF-1) with the overexpressed cathepsin C (CTSC) in metastatic breast tumors as the detecting substrate. This probe allows accurate identification of malignant tumor tissue specimens among tumor tissue specimens with unknown properties in a blind study. Importantly, a series of visible to NIR CTSC-activated fluorescence probes based on the same strategy realize effective identification of malignant tumor tissues, suggesting that CTSC could be the specific identification substrate of malignant breast tumors. Furthermore, a hydrophilic PEG moiety is coupled into YF-1, producing another CTSC-activated NIR probe (YF-2). YF-2 has excellent tumor-targeting capability, enabling the visualization of lung-metastatic breast tumors. The excellent detection accuracy and construction versatility of CTSC probes pave the way for preoperative diagnosis of malignant breast tumors.
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GB/T 7714 | Zuo, Shan , Li, Yanhua , Chen, Yushi et al. Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker [J]. | SCIENCE ADVANCES , 2025 , 11 (14) . |
MLA | Zuo, Shan et al. "Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker" . | SCIENCE ADVANCES 11 . 14 (2025) . |
APA | Zuo, Shan , Li, Yanhua , Chen, Yushi , Jiang, Gangwei , Zhou, Zhixuan , Ren, Tian-Bing et al. Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker . | SCIENCE ADVANCES , 2025 , 11 (14) . |
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Zero-dimensional (0D) halide perovskites have garnered significant interest due to their novel properties in optoelectronic and energy applications. However, the mechanisms underlying their phase transformations and fluorescence properties remain poorly understood. In this study, we have synthesized a micron-scale 0D perovskite observable under confocal laser scanning microscopy (CLSM). This approach enables us to trace the phase transformation process from 0D to three-dimensional (3D) structures, offering a deeper understanding of the underlying mechanisms. Remarkably, we discovered that this in situ transformation is highly sensitive to water, allowing for label-free fluorescent analysis of trace amounts of water in organic solvents through the phase transformation process. Additionally, we have designed a reusable paper strip for humidity analysis leveraging this sensitivity as an application of the micron scale material. Our findings not only elucidate the physicochemical properties of perovskites but also expand the potential of halide perovskite materials in analytical chemistry.
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GB/T 7714 | Xie, Lili , Qiu, Haiyan , Chen, Yuxin et al. Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications [J]. | RSC ADVANCES , 2024 , 14 (48) : 35490-35497 . |
MLA | Xie, Lili et al. "Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications" . | RSC ADVANCES 14 . 48 (2024) : 35490-35497 . |
APA | Xie, Lili , Qiu, Haiyan , Chen, Yuxin , Lu, Yingxue , Chen, Yanyan , Chen, Lanlan et al. Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications . | RSC ADVANCES , 2024 , 14 (48) , 35490-35497 . |
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The abnormal fluctuation of temperature in vivo usually reflects the progression of inflammatory diseases. Noninvasive, real-time, and accurate monitoring and imaging of temperature variation in vivo is advantageous for guiding the early diagnosis and treatment of disease, but it remains difficult to achieve. Herein, we developed a temperature-activated near-infrared-II fluorescence (NIR-II FL) and surface-enhanced Raman scattering (SERS) nanoprobe for long-term monitoring of temperature changes in rat arthritis and timely assessment of the status of osteoarthritis. The thermosensitive polymer bearing NIR-II FL dye was grafted onto the surface of nanoporous core-satellite gold nanostructures to form the nanoprobe, wherein the nanoprobe contains NIR-II FL and Raman reference signals that are independent of temperature change. The ratiometric FL1150/FL1550 and S-1528/S-2226 values of the nanoprobe exhibited a reversible conversion with temperature changes. The nanoprobe accurately distinguishes the temperature variations in the inflamed joint versus the normal joint in vivo by ratiometric FL and SERS imaging, allowing for an accurate diagnosis of inflammation. Meanwhile, it can continuously monitor fluctuations in temperature over an extended period during the onset and treatment of inflammation. The tested temperature change trend could be used as an indicator for early diagnosis of inflammation and real-time evaluation of therapeutic effects.
Keyword :
activatable probe activatable probe fluorescence imaging fluorescence imaging NIR-II NIR-II Raman spectroscopy Raman spectroscopy temperature temperature
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GB/T 7714 | Li, Qingqing , Xiao, Shenggan , Ge, Xiaoguang et al. Temperature-Activated Near-Infrared-II Fluorescence and SERS Dynamic-Reversible Probes for Long-Term Assessment of Osteoarthritis In Vivo [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (35) . |
MLA | Li, Qingqing et al. "Temperature-Activated Near-Infrared-II Fluorescence and SERS Dynamic-Reversible Probes for Long-Term Assessment of Osteoarthritis In Vivo" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63 . 35 (2024) . |
APA | Li, Qingqing , Xiao, Shenggan , Ge, Xiaoguang , Zheng, Liting , Wu, Ying , Du, Wei et al. Temperature-Activated Near-Infrared-II Fluorescence and SERS Dynamic-Reversible Probes for Long-Term Assessment of Osteoarthritis In Vivo . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (35) . |
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Background: Cell surface enzymes are important proteins that play essential roles in controlling a wide variety of biological processes, such as cell-cell adhesion, recognition and communication. Dysregulation of enzyme- catalyzed processes is known to contribute to numerous diseases, including cancer, cardiovascular diseases and neurodegenerative disease. From the perspective of drug discovery and development, there is a growing interest in detecting the cell surface enzyme activity, propelled by the arising need for innovative diagnostic and therapeutic approaches to address various health conditions. Results: In this review, we focus on advances in chemical strategies for the detection of cell surface enzyme activity. Firstly, this comprehensive review delves into the diverse landscape of cell surface enzymes, detailing their structural features and diverse biological functions. Various enzyme families on the cell surface are examined in depth, elucidating their roles in cellular homeostasis and signaling cascades. Subsequently, various biosensors, including electrochemical biosensors, optical biosensors and dual-mode biosensors, used for detecting the cell surface enzyme activity are described. Exemplars are provided to illustrate the mechanisms, limit of detection and prospective applications of these different biosensors. Furthermore, this review unravels the intricate interplay between cell surface enzymes and cellular physiology, contributing to the development of novel diagnostic and therapeutic strategies for various diseases. In the end, the review provides insights into the ongoing challenges and future prospects associated with the detection of cell surface enzyme activity. Significance: Detecting cell surface enzyme activity holds pivotal significance in biomedical research, offering valuable insights into cellular physiology and disease pathology. Understanding enzyme activity aids in eluci- dating signaling pathways, drug interactions and disease mechanisms. This knowledge informs the development of diagnostic tools and therapeutic interventions targeting various ailments, from cancer to neurodegenerative disease. Additionally, it contributes to the advancement of drug screening and personalized medicine approaches.
Keyword :
Cell surface enzyme Cell surface enzyme Chemical strategies Chemical strategies Dual-mode biosensors Dual-mode biosensors Electrochemical biosensors Electrochemical biosensors Optical biosensors Optical biosensors
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GB/T 7714 | Zhou, Zhilan , Chen, Tingting , Zhu, Yingdi et al. Unlocking cell surface enzymes: A review of chemical strategies for detecting enzymatic activity [J]. | ANALYTICA CHIMICA ACTA , 2024 , 1332 . |
MLA | Zhou, Zhilan et al. "Unlocking cell surface enzymes: A review of chemical strategies for detecting enzymatic activity" . | ANALYTICA CHIMICA ACTA 1332 (2024) . |
APA | Zhou, Zhilan , Chen, Tingting , Zhu, Yingdi , Chen, Lanlan , Li, Juan . Unlocking cell surface enzymes: A review of chemical strategies for detecting enzymatic activity . | ANALYTICA CHIMICA ACTA , 2024 , 1332 . |
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It remains a challenge to use a single probe to simultaneously detect extracellular pH fluctuations and specifically recognize cancer cells for precise drug delivery. Here, we engineered a tetrahedral framework nucleic acid-based logic nanoprobe (isgc8-tFNA) on live cell membranes for simultaneously monitoring extracellular pH and targeted drug delivery. Isgc8-tFNA was anchored stably on the cell surface through three cholesterol molecules inserting into the bilayer of the cell membrane. Once responding to the acidic tumor microenvironment, isgc8-tFNA formed an i-motif structure, leading to turn-on FRET signals for monitoring changes of extracellular pH. The nanoprobe exhibited a narrow pH-response window and excellent reversibility. Moreover, the nanoprobe could execute logic identification on the cell surface for precise drug delivery. Only if both in the acidic microenvironment and aptamer-targeting marker are present on the cell surface, the sgc8-ASO-chimera strand, carrying an antisense oligonucleotide drug, was released from the nanoprobe and entered into targeted cancer cells for gene silence. Additionally, the in situ drug release facilitated the uptake of drugs mediated by the interaction between sgc8 aptamer and membrane proteins, resulting in enhanced inhibition of cancer cell migration and proliferation. This logic nanoprobe will provide inspiration for designing smart devices for diagnosis of pH-related diseases and targeted drug delivery.
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GB/T 7714 | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi et al. Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (8) : 3462-3469 . |
MLA | Chen, Wanzhen et al. "Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery" . | ANALYTICAL CHEMISTRY 96 . 8 (2024) : 3462-3469 . |
APA | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi , Chen, Lanlan , Yang, Huanghao . Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery . | ANALYTICAL CHEMISTRY , 2024 , 96 (8) , 3462-3469 . |
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Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity. However, traditional disposal strategies have limitations, including high energy consumption, use of aggressive reagents and generation of toxic byproducts. Here, inspired by the compartmentalized architecture and detoxification mechanism of bacterial micro-compartments, we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant (2-chloroethyl ethyl sulfide, CEES) under sweet conditions. Two exemplified droplet systems were developed with two-enzyme (glucose oxidase/chloroperoxidase) and three-enzyme (invertase/glucose oxidase/chloroperoxidase) cascades, both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and >99% selectivity towards non-toxic sulfoxide. We found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination efficacy. More importantly, the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles, following long-term storage and in far-field locations.
Keyword :
bacterial microcompartment bacterial microcompartment biocatalysis biocatalysis biomimetics biomimetics chemical warfare agent chemical warfare agent Pickering emulsion Pickering emulsion
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GB/T 7714 | Xu, Xiao , Xie, Wenqi , Wu, Ting et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions [J]. | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) : 3039-3049 . |
MLA | Xu, Xiao et al. "Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions" . | SCIENCE CHINA-CHEMISTRY 67 . 9 (2024) : 3039-3049 . |
APA | Xu, Xiao , Xie, Wenqi , Wu, Ting , Chen, Chen , Chen, Xiaoning , Yang, Yuheng et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions . | SCIENCE CHINA-CHEMISTRY , 2024 , 67 (9) , 3039-3049 . |
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MicroRNA-21 (MiR-21) has been confirmed to be upregulated in tumors, and its abnormal expression is closely associated with tumor occurrence. However, the traditional imaging methods are limited to qualitative imaging of miR-21, and no effective strategy has been developed for monitoring its concentration in vivo during cancer initiation and progression. Herein, a biosensor is created utilizing a NIR-II ratiometric fluorescent nanoprobe to quantitatively monitor dynamic alterations in miR-21 levels in vivo. The nanoprobe (termed DCNP@DNA2@IR806) is constructed by introducing IR806 as a donor and down-conversion nanoparticles (DCNP) as the acceptor, using DNA as linkers. Upon miR-21-responsive initiation of the nanoprobe, the 1550 nm fluorescent signal of DCNP stimulated by a 808 nm laser (F1550, 808Ex) increased because of the close proximity of IR806 to the DCNP and the subsequent non-radiative energy transfer (NRET). Meanwhile, the 1550 nm fluorescent signal of DCNP stimulated by a 980 nm laser (F1550, 980Ex) remained stable because of the absence of NRET. This ratiometric NIR-II fluorescent signal has been confirmed to be a reliable indicator of miR-21 concentration in vivo. The strategy holds promise for further enhancing the understanding of microRNAs-based molecular mechanisms underlying cancer progression, laying a foundation for the early diagnosis of microRNAs-related diseases. A miR-21-activated ratiometric NIR-II fluorescence nanoprobe (DCNP@DNA2@IR806) for early diagnosis and real-time monitoring of miR-21 levels during cancer initiation and progression via enhanced ratiometric fluorescence signals in vivo. The content of activated miR-21 is positively correlated with tumor volume in the development of tumors. image
Keyword :
biosensors biosensors initiation and progression initiation and progression microRNA-21 microRNA-21 nanoprobes nanoprobes NIR-II fluorescence imaging NIR-II fluorescence imaging
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GB/T 7714 | Zheng, Liting , Wu, Ying , Wang, Qian et al. Quantitative Imaging of MicroRNA-21 In Vivo for Real-Time Monitoring of the Cancer Initiation and Progression [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (45) . |
MLA | Zheng, Liting et al. "Quantitative Imaging of MicroRNA-21 In Vivo for Real-Time Monitoring of the Cancer Initiation and Progression" . | ADVANCED FUNCTIONAL MATERIALS 34 . 45 (2024) . |
APA | Zheng, Liting , Wu, Ying , Wang, Qian , Du, Wei , Chen, Lanlan , Song, Jibin et al. Quantitative Imaging of MicroRNA-21 In Vivo for Real-Time Monitoring of the Cancer Initiation and Progression . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 34 (45) . |
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Helicobacter Pylori infection is drawing increasing attentions in public health, especially the drug resistance problems induced by Single-Nucleotide Variants (SNV). Diagnosis of H. Pylori remains challenging for its requirement in selectivity and sensitivity. Herein an initial check-reexamination strategy is designed for analysis of H. Pylori DNA and SNV. At the first stage, target DNA with all genotypes is captured to form a Y-shaped structure, resulting in an electrochemiluminescence (ECL) signal recovered from quenched states. Then Cas9 assisted cleavage processes are followed to cut off the Y-shaped structure, resulting in corresponding signal decrease. By means of these two stages with different selectivity, both the total amount of H. Pylori DNA and the ratio of SNV can be clarified. To expand its capacity, a large-scale screening assay is carried out on chip. Array detection improves the reliability and the following PCA analysis confirms the otherness. This approach improved the work efficiency and reduced the cost, which may offer an appealing option for the prevention and cure of H. pylori infections in the future.
Keyword :
CRISPR/Cas9 CRISPR/Cas9 Electrochemiluminescence Electrochemiluminescence Helicobacter pylori Helicobacter pylori Single-nucleotide variants Single-nucleotide variants
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GB/T 7714 | Hu, Shanwen , Zhong, Xinyi , Deng, Yuan et al. An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 398 . |
MLA | Hu, Shanwen et al. "An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants" . | SENSORS AND ACTUATORS B-CHEMICAL 398 (2024) . |
APA | Hu, Shanwen , Zhong, Xinyi , Deng, Yuan , Deng, Yuhang , Chen, Lanlan . An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants . | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 398 . |
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