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学者姓名：陈岚岚
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Abstract ：
Evaluating tumor radiosensitivity is beneficial for the prediction of treatment efficacy, customization of treatment plans, and minimization of side effects. Tracking the mitochondrial DNA (mtDNA) repair process helps to assess tumor radiosensitivity as mtDNA repair determines the fate of the cell under radiation-induced mtDNA damage. However, current probes developed to monitor levels of DNA repair enzymes suffered from complex synthesis, uncontrollable preparation, limited tumor selectivity, and poor organelle-targeting ability. Especially, the correlation between mtDNA repair activity and inherent radiosensitivity of tumors has not yet been explored. Here, we present a mitochondria-targeted DNA-based nanoprobe (TPP-Apt-tFNA) for in situ monitoring of the activity of the mtDNA repair enzyme and evaluating tumor radiosensitivity. TPP-Apt-tFNA consists of a DNA tetrahedral framework precisely modified with three functional modules on each of the three vertexes, that is, the tumor cell-targeting aptamer, the mitochondrion-targeting moiety, and the apurinic/apyrimidinic endonuclease 1 (APE1)-responsive molecule beacon. Once selectively internalized by tumor cells, the nanoprobe targeted the mitochondrion and specifically recognized APE1 to activate fluorescence, allowing the observation of mtDNA repair activity. The nanoprobe showed elevated APE1 levels in the mitochondria of tumor cells under oxidative stress. Moreover, the nanoprobe enabled the illumination of different levels of APE1-mediated mtDNA repair activity in different cell cycle phases. Furthermore, using the nanoprobe in vitro and in vivo, we found that tumor cells with high activity of mtDNA repair, which allowed them to recover from radiation-induced mtDNA lesions, had low sensitivity to radiation and an unsatisfactory radiotherapy outcome. Our work provides a new imaging tool for exploring the roles of mtDNA repair activity in diverse biological processes and for guiding tumor radiation treatment.
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| GB/T 7714 | Chen, Lanlan , Lai, Jingjing , Dong, Siqi et al. Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity [J]. | ANALYTICAL CHEMISTRY , 2025 , 97 (1) : 382-391 . |
| MLA | Chen, Lanlan et al. "Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity" . | ANALYTICAL CHEMISTRY 97 . 1 (2025) : 382-391 . |
| APA | Chen, Lanlan , Lai, Jingjing , Dong, Siqi , Liu, Wenjun , Zhang, Ximei , Yang, Huanghao . Mitochondria-Targeted DNA-Based Nanoprobe for In Situ Monitoring of the Activity of the mtDNA Repair Enzyme and Evaluating Tumor Radiosensitivity . | ANALYTICAL CHEMISTRY , 2025 , 97 (1) , 382-391 . |
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Accurate differentiation of benign and malignant breast tumors is paramount for establishing schemes of breast cancer treatment and prognosis. Here we report a near-infrared (NIR) fluorescence probe (YF-1) with the overexpressed cathepsin C (CTSC) in metastatic breast tumors as the detecting substrate. This probe allows accurate identification of malignant tumor tissue specimens among tumor tissue specimens with unknown properties in a blind study. Importantly, a series of visible to NIR CTSC-activated fluorescence probes based on the same strategy realize effective identification of malignant tumor tissues, suggesting that CTSC could be the specific identification substrate of malignant breast tumors. Furthermore, a hydrophilic PEG moiety is coupled into YF-1, producing another CTSC-activated NIR probe (YF-2). YF-2 has excellent tumor-targeting capability, enabling the visualization of lung-metastatic breast tumors. The excellent detection accuracy and construction versatility of CTSC probes pave the way for preoperative diagnosis of malignant breast tumors.
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| GB/T 7714 | Zuo, Shan , Li, Yanhua , Chen, Yushi et al. Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker [J]. | SCIENCE ADVANCES , 2025 , 11 (14) . |
| MLA | Zuo, Shan et al. "Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker" . | SCIENCE ADVANCES 11 . 14 (2025) . |
| APA | Zuo, Shan , Li, Yanhua , Chen, Yushi , Jiang, Gangwei , Zhou, Zhixuan , Ren, Tian-Bing et al. Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker . | SCIENCE ADVANCES , 2025 , 11 (14) . |
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Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective and personalized cancer treatments. However, the requirement of high doses of X-ray irradiation to break chemical bonds for drug release limits the application of radiotherapy-induced prodrug activation in clinics. Recent advances in nanomaterials offer a promising approach for radiotherapy sensitization as well as integrating multiple modalities for improved therapy outcomes. In particular, the catalytic radiosensitization that utilizes electrons and energy generated by nanomaterials upon X-ray irradiation has demonstrated excellent potential for enhanced radiotherapy. In this Review, we summarize the design principles of X-ray-responsive chemical bonds for controlled drug release, strategies for catalytic radiosensitization, and recent progress of X-ray-responsive nanoradiosensitizers for enhanced radiotherapy by integration with chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, gas therapy, and immunotherapy. Finally, we discuss the challenges of X-ray-responsive nanoradiosensitizers heading toward possible clinical translation. We expect that emerging strategies based on radiotherapy-triggered drug release will facilitate a frontier in accurate and effective cancer therapy in the near future.
Keyword ：
combined therapy combined therapy nanomaterials nanomaterials radiosensitive radiosensitive radiotherapy radiotherapy X-ray responsivedrug release X-ray responsivedrug release
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| GB/T 7714 | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun et al. Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release [J]. | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) : 14801-14821 . |
| MLA | Jiang, Renfeng et al. "Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release" . | ACS APPLIED MATERIALS & INTERFACES 17 . 10 (2025) : 14801-14821 . |
| APA | Jiang, Renfeng , Fang, Qiong , Liu, Wenjun , Chen, Lanlan , Yang, Huanghao . Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release . | ACS APPLIED MATERIALS & INTERFACES , 2025 , 17 (10) , 14801-14821 . |
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Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity. However, traditional disposal strategies have limitations, including high energy consumption, use of aggressive reagents and generation of toxic byproducts. Here, inspired by the compartmentalized architecture and detoxification mechanism of bacterial micro-compartments, we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant (2-chloroethyl ethyl sulfide, CEES) under sweet conditions. Two exemplified droplet systems were developed with two-enzyme (glucose oxidase/chloroperoxidase) and three-enzyme (invertase/glucose oxidase/chloroperoxidase) cascades, both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and >99% selectivity towards non-toxic sulfoxide. We found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination efficacy. More importantly, the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles, following long-term storage and in far-field locations. © The Author(s) 2024.
Keyword ：
bacterial microcompartment bacterial microcompartment biocatalysis biocatalysis biomimetics biomimetics chemical warfare agent chemical warfare agent Pickering emulsion Pickering emulsion
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| GB/T 7714 | Xu, X. , Xie, W. , Wu, T. et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions [J]. | Science China Chemistry , 2024 , 67 (9) : 3039-3049 . |
| MLA | Xu, X. et al. "Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions" . | Science China Chemistry 67 . 9 (2024) : 3039-3049 . |
| APA | Xu, X. , Xie, W. , Wu, T. , Chen, C. , Chen, X. , Yang, Y. et al. Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions . | Science China Chemistry , 2024 , 67 (9) , 3039-3049 . |
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Zero-dimensional (0D) halide perovskites have garnered significant interest due to their novel properties in optoelectronic and energy applications. However, the mechanisms underlying their phase transformations and fluorescence properties remain poorly understood. In this study, we have synthesized a micron-scale 0D perovskite observable under confocal laser scanning microscopy (CLSM). This approach enables us to trace the phase transformation process from 0D to three-dimensional (3D) structures, offering a deeper understanding of the underlying mechanisms. Remarkably, we discovered that this in situ transformation is highly sensitive to water, allowing for label-free fluorescent analysis of trace amounts of water in organic solvents through the phase transformation process. Additionally, we have designed a reusable paper strip for humidity analysis leveraging this sensitivity as an application of the micron scale material. Our findings not only elucidate the physicochemical properties of perovskites but also expand the potential of halide perovskite materials in analytical chemistry.
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| GB/T 7714 | Xie, Lili , Qiu, Haiyan , Chen, Yuxin et al. Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications [J]. | RSC ADVANCES , 2024 , 14 (48) : 35490-35497 . |
| MLA | Xie, Lili et al. "Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications" . | RSC ADVANCES 14 . 48 (2024) : 35490-35497 . |
| APA | Xie, Lili , Qiu, Haiyan , Chen, Yuxin , Lu, Yingxue , Chen, Yanyan , Chen, Lanlan et al. Construction of a zero-dimensional halide perovskite in micron scale towards a deeper understanding of phase transformation mechanism and fluorescence applications . | RSC ADVANCES , 2024 , 14 (48) , 35490-35497 . |
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Oxidative stress, orchestrated by myeloperoxidase (MPO), plays crucial roles in the progression of many diseases. Nonetheless, the role of MPO-mediated oxidative stress in distinct factor-induced acute liver injuries (ALI) is still up for dispute, mainly due to the lack of probes for in vivo monitoring of MPO releases. Here, a highly selective MPO probe (CSQ) based on the epoxidation biochemical reaction within the MPO-H2O2-Cl- system is screened to construct dual near infrared-IIb (NIR-IIb) ratiometric (F-1550Em,F- 808Ex/F-1550Em,F- 980Ex) luminescence nanoprobes by integrating CSQ onto down conversion nanoparticles (DCNPs) with and without liver-targeting moiety (twin NIR-IIb nanoprobes). Liver-targeting probes are employed to monitor MPO release, whereas non-liver-targeting probes are utilized to assess MPO activity across all cell types. Using twin NIR-IIb nanoprobes, the MPO-mediated oxidative stress progressively increased are observed in carbon tetrachloride (CCl4)-induced ALI over 12 h. In contrast, the MPO-mediated oxidative stress in acetaminophen (APAP)-induced ALI initially increased, peaked within 3 h, and then rapidly weakened to normal levels within 12 h. Importantly, the differential release of MPO from neutrophils/Kupfer cells to extracellular fluids in the two types of ALI is revealed. This work reveals significant differences in MPO distribution and the role of MPO-mediated oxidative stress in CCl4 and APAP-induced ALI.
Keyword ：
APAP-induced liver injury APAP-induced liver injury CCl4-induced liver injury CCl4-induced liver injury MPO-mediated oxidative stress MPO-mediated oxidative stress NIR-IIb ratiometric luminescence imaging NIR-IIb ratiometric luminescence imaging selective HOCl nanoprobe selective HOCl nanoprobe
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| GB/T 7714 | Liu, Xiao , Li, Wei , Shen, Yang et al. Selective Twin NIR-IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO-Mediated Oxidative Stress in Acute Liver Injury [J]. | ADVANCED FUNCTIONAL MATERIALS , 2024 , 35 (6) . |
| MLA | Liu, Xiao et al. "Selective Twin NIR-IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO-Mediated Oxidative Stress in Acute Liver Injury" . | ADVANCED FUNCTIONAL MATERIALS 35 . 6 (2024) . |
| APA | Liu, Xiao , Li, Wei , Shen, Yang , He, Linhui , Lai, Huanhua , Chen, Yushi et al. Selective Twin NIR-IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO-Mediated Oxidative Stress in Acute Liver Injury . | ADVANCED FUNCTIONAL MATERIALS , 2024 , 35 (6) . |
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Helicobacter Pylori infection is drawing increasing attentions in public health, especially the drug resistance problems induced by Single-Nucleotide Variants (SNV). Diagnosis of H. Pylori remains challenging for its requirement in selectivity and sensitivity. Herein an initial check-reexamination strategy is designed for analysis of H. Pylori DNA and SNV. At the first stage, target DNA with all genotypes is captured to form a Y-shaped structure, resulting in an electrochemiluminescence (ECL) signal recovered from quenched states. Then Cas9 assisted cleavage processes are followed to cut off the Y-shaped structure, resulting in corresponding signal decrease. By means of these two stages with different selectivity, both the total amount of H. Pylori DNA and the ratio of SNV can be clarified. To expand its capacity, a large-scale screening assay is carried out on chip. Array detection improves the reliability and the following PCA analysis confirms the otherness. This approach improved the work efficiency and reduced the cost, which may offer an appealing option for the prevention and cure of H. pylori infections in the future.
Keyword ：
CRISPR/Cas9 CRISPR/Cas9 Electrochemiluminescence Electrochemiluminescence Helicobacter pylori Helicobacter pylori Single-nucleotide variants Single-nucleotide variants
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| GB/T 7714 | Hu, Shanwen , Zhong, Xinyi , Deng, Yuan et al. An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants [J]. | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 398 . |
| MLA | Hu, Shanwen et al. "An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants" . | SENSORS AND ACTUATORS B-CHEMICAL 398 (2024) . |
| APA | Hu, Shanwen , Zhong, Xinyi , Deng, Yuan , Deng, Yuhang , Chen, Lanlan . An initial check-reexamination strategy for analysis of H. Pylori DNA and single-nucleotide variants . | SENSORS AND ACTUATORS B-CHEMICAL , 2024 , 398 . |
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It remains a challenge to use a single probe to simultaneously detect extracellular pH fluctuations and specifically recognize cancer cells for precise drug delivery. Here, we engineered a tetrahedral framework nucleic acid-based logic nanoprobe (isgc8-tFNA) on live cell membranes for simultaneously monitoring extracellular pH and targeted drug delivery. Isgc8-tFNA was anchored stably on the cell surface through three cholesterol molecules inserting into the bilayer of the cell membrane. Once responding to the acidic tumor microenvironment, isgc8-tFNA formed an i-motif structure, leading to turn-on FRET signals for monitoring changes of extracellular pH. The nanoprobe exhibited a narrow pH-response window and excellent reversibility. Moreover, the nanoprobe could execute logic identification on the cell surface for precise drug delivery. Only if both in the acidic microenvironment and aptamer-targeting marker are present on the cell surface, the sgc8-ASO-chimera strand, carrying an antisense oligonucleotide drug, was released from the nanoprobe and entered into targeted cancer cells for gene silence. Additionally, the in situ drug release facilitated the uptake of drugs mediated by the interaction between sgc8 aptamer and membrane proteins, resulting in enhanced inhibition of cancer cell migration and proliferation. This logic nanoprobe will provide inspiration for designing smart devices for diagnosis of pH-related diseases and targeted drug delivery.
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| GB/T 7714 | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi et al. Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery [J]. | ANALYTICAL CHEMISTRY , 2024 , 96 (8) : 3462-3469 . |
| MLA | Chen, Wanzhen et al. "Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery" . | ANALYTICAL CHEMISTRY 96 . 8 (2024) : 3462-3469 . |
| APA | Chen, Wanzhen , Lai, Jingjing , Dong, Siqi , Chen, Lanlan , Yang, Huanghao . Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery . | ANALYTICAL CHEMISTRY , 2024 , 96 (8) , 3462-3469 . |
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The abnormal fluctuation of temperature in vivo usually reflects the progression of inflammatory diseases. Noninvasive, real-time, and accurate monitoring and imaging of temperature variation in vivo is advantageous for guiding the early diagnosis and treatment of disease, but it remains difficult to achieve. Herein, we developed a temperature-activated near-infrared-II fluorescence (NIR-II FL) and surface-enhanced Raman scattering (SERS) nanoprobe for long-term monitoring of temperature changes in rat arthritis and timely assessment of the status of osteoarthritis. The thermosensitive polymer bearing NIR-II FL dye was grafted onto the surface of nanoporous core-satellite gold nanostructures to form the nanoprobe, wherein the nanoprobe contains NIR-II FL and Raman reference signals that are independent of temperature change. The ratiometric FL1150/FL1550 and S-1528/S-2226 values of the nanoprobe exhibited a reversible conversion with temperature changes. The nanoprobe accurately distinguishes the temperature variations in the inflamed joint versus the normal joint in vivo by ratiometric FL and SERS imaging, allowing for an accurate diagnosis of inflammation. Meanwhile, it can continuously monitor fluctuations in temperature over an extended period during the onset and treatment of inflammation. The tested temperature change trend could be used as an indicator for early diagnosis of inflammation and real-time evaluation of therapeutic effects.
Keyword ：
activatable probe activatable probe fluorescence imaging fluorescence imaging NIR-II NIR-II Raman spectroscopy Raman spectroscopy temperature temperature
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| GB/T 7714 | Li, Qingqing , Xiao, Shenggan , Ge, Xiaoguang et al. Temperature-Activated Near-Infrared-II Fluorescence and SERS Dynamic-Reversible Probes for Long-Term Assessment of Osteoarthritis In Vivo [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (35) . |
| MLA | Li, Qingqing et al. "Temperature-Activated Near-Infrared-II Fluorescence and SERS Dynamic-Reversible Probes for Long-Term Assessment of Osteoarthritis In Vivo" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 63 . 35 (2024) . |
| APA | Li, Qingqing , Xiao, Shenggan , Ge, Xiaoguang , Zheng, Liting , Wu, Ying , Du, Wei et al. Temperature-Activated Near-Infrared-II Fluorescence and SERS Dynamic-Reversible Probes for Long-Term Assessment of Osteoarthritis In Vivo . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2024 , 63 (35) . |
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本研究建立了一种利用催化发夹自组装反应阵列对多种微生物进行联合检测的新方法.该方法采用双靶点策略,第一个靶点为原核生物 16S rRNA的一段保守序列,用于初步判定原核生物,第二个靶点分别为大肠埃希氏菌、单核增生李斯特菌、金黄色葡萄球菌的特异性序列,用于确证微生物种类.双靶点识别后,释放引发链触发催化发夹自组装反应,循环打开带有FAM荧光基团和猝灭基团标记的发夹探针,产生荧光信号.优化反应条件,评价信号的稳定性后,建立对靶标序列检测的工作曲线,通过荧光信号实现对多种微生物的鉴定和定量检测,并建立检测阵列.本方法在靶标浓度为3～50 nmol/L范围内具有良好的线性关系,检出限为0.001 nmol/L.在阵列检测中,本方法能够有效区分3种目标微生物,为多种病原微生物的同时检测提供了新的技术思路.
Keyword ：
催化发夹自组装 催化发夹自组装 病原微生物 病原微生物 阵列检测 阵列检测
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| GB/T 7714 | 黄敏芳 , 庄妙慧 , 张习梅 et al. 基于催化发夹自组装的多种病原微生物阵列检测 [J]. | 中国口岸科学技术 , 2024 , 6 (9) : 70-77 . |
| MLA | 黄敏芳 et al. "基于催化发夹自组装的多种病原微生物阵列检测" . | 中国口岸科学技术 6 . 9 (2024) : 70-77 . |
| APA | 黄敏芳 , 庄妙慧 , 张习梅 , 陈岚岚 . 基于催化发夹自组装的多种病原微生物阵列检测 . | 中国口岸科学技术 , 2024 , 6 (9) , 70-77 . |
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