This　study　aims　to　better　understand　the　seismic　responses　and　isolation　effect　of　a　first-story,　independent,　column-top　isolation　structure　with　concrete　frames.　A　series　of　shaking　table　tests　and　a　numerical　simulation　were　performed　on　a　seven-story　reinforced　concrete-framed　structure　with　first-story　isolation,　using　rubber　bearings.　A　non-isolated,　structural　model　was　used　as　a　reference　for　comparison.　The　testing　and　numerical　results　showed　that　the　story　acceleration　and　inter-story　displacement　of　the　superstructure　in　the　isolation　model　were　significantly　reduced,　indicating　the　good　damping　effect　of　the　isolation　system.　This　system,　which　composed　of　rubber　bearings,　could　absorb　most　of　the　seismic　energy.　The　inter-story　displacement　of　the　substructure　in　the　isolation　model　was　also　significantly　reduced,　while　the　acceleration　was　slightly　reduced.　The　horizontal　deformation　of　the　column　was　not　severe,　and　the　seismic　capacity　of　the　substructure　was　higher　than　that　of　the　superstructure.　It　is　suggested　that　to　guarantee　the　seismic　security　of　reinforced　concrete-framed　structures　with　the　first-story　column-top　isolation　under　extremely　rare　strong　earthquakes,　the　stiffness　of　columns　in　the　substructure　should　be　further　strengthened.　Moreover,　it　is　effective　and　reasonable　to　adopt　the　first-story　column-top　isolation　method　to　improve　the　seismic　capacity　of　reinforced　concrete-framed　structures　with　a　weak　first　story.