This　study　proposes　a　new　structural　design　of　the　first-story　isolation　system　in　reinforced　concrete　(RC)　structures.　Compared　to　the　conditional　buildings　with　independent　columns,　this　new　design　integrates　the　independent　columns　with　beams　to　increase　the　seismic　capacity　of　the　building　by　increasing　the　integrated　stiffness　of　the　coupled　columns　and　the　stability　of　the　isolation　system.　The　seismic　responses　of　the　proposed　structure　and　the　corresponding　isolation　effect　were　investigated　by　performing　a　series　of　numerical　simulation　and　shaking　table　tests　on　a　typical　7-story　RC　frame　structure.　The　structure　models　were　subjected　to　four　earthquake　waves　with　two　PGAs　(peak　ground　acceleration)　of　0.30　g　and　0.40　g　for　seismic　analysis　regarding　the　peak　acceleration　and　inter-story　displacement.　Both　simulation　and　testing　results　showed　that　the　story　acceleration　and　inter-story　displacement　of　the　superstructure　in　the　isolated　model　decreased　significantly.　While　the　substructure　below　the　isolation　layer　had　a　negligible　decrease　of　acceleration.　The　connection　of　beams　with　concrete　columns　significantly　increases　the　seismic　capacity　of　the　RC　frame　buildings　compared　to　non-isolated　frame　buildings.　The　coupled　beam-column　connections　could　thus　be　potentially　adopted　in　the　practical　first-story　isolation　system　to　avoid　the　requirements　of　large　column　stiffness　and　large　column　size.