In　this　report　a　fast　and　sensitive　electrochemical　sensor　for　simultaneous　determination　of　DA,　AC　and　Tyr　was　proposed　based　on　the　Au@Pd　HNRs/BG　hybrid　nanocomposites.　Firstly,　the　incorporation　of　B　atom　into　graphene　with　porous　framework　was　achieved　by　one-pot　hydrothermal　approach.　Secondly,　the　Au@Pd　hybrid　nanorods　(Au@Pd　HNRs)　were　encapsulated　in　B-doped　graphene　(BG)　to　form　Au@Pd　HNRs/BG　hybrid　nanocatalysts.　Interestingly,　boron-doping　effect　introduce　the　highly　dispersed　COOH　groups　and　abundant　defect　sites,　which　not　only　improve　the　interfacial　properties　of　Au@Pd　HNRs,　resulting　ultrathin　BG　effectively　enwrapped　most　of　individual　Au@Pd　HNRs　with　excellent　dispersibility,　but　the　-COOH　units　form　hydrogen　bonding　with　the　phenolic　hydroxyl　groups　of　DA,　AC　and　Tyr,　which　provide　a　large　specific　surface　area　to　increase　their　loading　amount　and　improve　the　excellent　electro-catalytic　effect　the　three　analytes.　Therefore,　high　enough　anodic　peaks　potential　separation　of　DA,　AC　and　Tyr　and　increased　peak　currents　at　Au@Pd　HNRs/BG/GCE　was　provided　a　simultaneous　sensitively　determination　of　them　with　extraordinary　stability　and　cost　effective　analysis,　the　detection　limits　(S/N=3)　for　determination　of　DA,　AC　and　Tyr　were　found　to　be　4.58,　6.35　and　3.71　mu　M,　respectively.　Finally,　the　as-fabricated　sensor　was　satisfactorily　used　for　the　determination　of　DA,　AC　and　Tyr　in　the　urine　sample　with　acceptable　recovery　range.