Ketoreductase　(KRED)-catalyzed　dynamic　reductive　kinetic　resolution　(DYRKR)　of　alpha-substituted-beta-keto　arylphosphonates　was　developed　as　a　generic　and　stereoselective　approach　to　synthesize　chiral　alpha-substituted-beta-hydroxy　arylphosphonates,　with　moderate-to-excellent　isolated　yield　(up　to　96%),　good-to-excellent　diastereoselectivity　(up　to　＞99　:　＜1　dr),　and　excellent　enantioselectivity　(up　to　＞99%　ee)　being　achieved.