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author:

Tang, Yun-dong (Tang, Yun-dong.) [1] (Scholars:汤云东) | Flesch, Rodolfo C. C. (Flesch, Rodolfo C. C..) [2] | Jin, Tao (Jin, Tao.) [3] (Scholars:金涛)

Indexed by:

EI Scopus SCIE

Abstract:

Magnetic hyperthermia ablates malignant cells by heating a tumor region when magnetic nanoparticles (MNPs) are subjected to a high-frequency magnetic field. The treatment effect for magnetic hyperthermia can be evaluated by the mortality of malignant cells, which is mainly determined by the temperature profile of therapeutic target, treatment duration, Arrhenius kinetic coefficients, and also the material of MNPs. Both of these interests should be designed properly for a clinical consideration. This paper evaluates the survival rate of malignant cells by using an improved Arrhenius model, in which both treatment temperature profile and therapeutic duration are all taken into consideration. The treatment temperature profile for a proposed geometric model is predicted by solving Pennes bio-heat transfer equation using finite element method, in which a heat source in form of a Gaussian distribution is used as the power dissipation of MNPs. In addition, a kind of MNPs with low Curie temperature is considered to further improve the therapeutic effect for magnetic hyperthermia in this paper. Simulation results demonstrate that the temperature profile considering the MNPs with low Curie temperature can be more homogeneous than the case using Fe3O4 particles if their power dissipation are increased properly with respect to a critical value for the Fe3O4 particles. This better distribution in treatment temperature will then result in an obviously positive effects in malignant ablation for magnetic hyperthermia. Meanwhile, results also show that the survival rate of tumor cells is not only relevant to the therapeutic temperature and duration, but also depends more on the kinetic parameters due to the individual characteristic of malignant cells.

Keyword:

Arrhenius model Magnetic hyperthermia The survival rate of malignant cells Treatment temperature profile

Community:

  • [ 1 ] [Tang, Yun-dong]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350116, Fujian, Peoples R China
  • [ 2 ] [Flesch, Rodolfo C. C.]Univ Fed Santa Catarina, Dept Automacao & Sistemas, BR-88040900 Florianopolis, SC, Brazil
  • [ 3 ] [Jin, Tao]Fuzhou Univ, Coll Elect Engn & Automat, Fuzhou 350116, Fujian, Peoples R China

Reprint 's Address:

  • 金涛

    [Jin, Tao]Fuzhou Univ, Coll Elect Engn & Automat, Fuzhou 350116, Fujian, Peoples R China

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Source :

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

ISSN: 0304-8853

Year: 2019

Volume: 490

2 . 7 1 7

JCR@2019

2 . 5 0 0

JCR@2023

ESI Discipline: PHYSICS;

ESI HC Threshold:138

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 19

SCOPUS Cited Count: 20

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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