The　macrocyclic　complex　catalyzed　Briggs-Rauscher　(BR)　oscillator　was　used　to　determine　the　antioxidants　activity　of　natural　polyphenolic　compounds　(tannic　acid,　chlorogenic　acid,　and　luteolin)　in　this　paper.　The　complex　Ni　catalyst　is　donated　by　NiL(ClO4)(2)　where　the　ligand　L　in　the　complex　is　5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene.　The　overall　reaction　pH　was　maintained　at　2,　which　is　similar　to　the　pH　of　the　human　stomach.　Experimental　results　have　shown　that　as　per　addition　of　the　above　antioxidants　into　the　BR　system,　the　temporarily　cessation　of　oscillation　was　noticed　and　inhibition　time　linearly　depends　on　the　concentration　of　antioxidants　added.　The　evaluation　of　natural　polyphenolic　compound,　antioxidants　activity　was　tested　successfully.　The　three　natural　polyphenolic　compounds　tested　are　tannic　acid,　chlorogenic　acid,　and　luteolin.　In　these　three　natural　compounds,　the　chlorogenic　acid　was　found　the　most　proficient　antioxidant.　The　perturbation　mechanism　involving　HOO　center　dot　radical　based　on　FCA　model　was　suggested.