A　new　enzyme-free　and　portable　photoelectrochemical　sensing　method　based　on　a　homemade　three-dimensional　(3D)　printing　device　was　developed　for　accurate　monitoring　of　a　low-abundance　cancer　biomarker　(carcinoembryonic　antigen,　CEA,　was　chosen　as　a　model　analyte　in　this　work),　coupling　glucose-encapsulated　liposomes　with　a　digital　multimeter　readout.