To　improve　the　cancer　targeting　and　anticancer　efficacy,　the　multifunctional　Eu-based　metal-organic　framework　(EuBTC)　is　post-synthetically　modified　with　a　targeting　moiety　folic　acid　and　a　zinc　phthalocyanine　photosensitizer.　In　addition,　this　nanosphere　is　also　applied　as　a　drug　delivery　system　to　load　the　chemical　drug　doxorubicin.　Electron　microscopy,　powder　X-ray　diffraction　and　infrared　spectometry　demonstrated　the　formation　of　these　multifunctional　nanospheres　(DOX).　Our　nanospheres　kept　the　high　singlet　oxygen　quantum　yield　of　zinc　phthalocyanine.　Additionally,　Cell　viability　experiments　demonstrated　the　biosafety　of　EuBTC　and　the　enhanced　anticancer　effect　of　DOX@FA-EuBTC-Pc　under　light　irradiation.　In　short,　these　well-arranged　DOX@FA-Eu-BTC-Pcs　exhibit　as　promising　drug　delivery　systems　for　enhanced　targeted　anticancer　therapy.