Extracellular　hydrogen　peroxide　(H2O2)　plays　a　significant　role　in　regulating　a　variety　of　neural　functions,　such　as　atherosclerosis,　ischemia　and　so　on.　It　is　necessary　to　develop　a　sensing　platform　for　monitoring　H2O2　in　the　central　nervous　system,　especially　during　pathological　processes.　However,　the　design　and　synthesis　of　fluorescent　probes,　which　can　detect　H2O2　in　living　cells　or　tissue,　still　have　problems　with　toxicity.　Herein,　an　effective　and　biocompatible　H2O2　stimuli-responsive　chemical　sensing　platform　has　been　developed　based　on　mesoporous　silica　nanoparticles　(MSNPs).　Firstly,　MSNPs　were　functionalized　with　phenylboronic　acid　groups.　Then　the　functionalized　MSNPs　reacted　with　glucose　modified　Au　nanoparticles　(Au　NPs@glucose)　through　the　carbohydrate-boronic　acid　interaction,　encapsulating　the　molecular　cargo　inside　the　MSNPs.　Transmission　electron　microscopy　(TEM),　Brunauer-Emmett-Teller　(BET),　and　zeta　potential　were　employed　to　characterize　the　morphology　and　surface　properties　of　these　materials.　The　cargo　was　held　in　the　blocked　mesopores　of　the　MSNPs　with　high　efficiency　and　almost　no　leakage　was　detected.　The　target,　H2O2,　oxidized　the　arylboronic　esters,　causing　the　release　of　Au　NPs　from　MSNPs　and　thereby　resulting　in　the　release　of　cargo.　This　sensing　platform　can　be　used　to　monitor　the　extracellular　H2O2　concentration,　which　will　help　in　physiological　and　pathological　studies　associated　with　H2O2　in　the　rat　brain.