This　paper　presents　the　evaluation　of　the　loss-of-support　conditions　in　frictional　beam-to-column　connections　of　industrial　precast　concrete　buildings　under　seismic　actions.　This　type　of　connection　is　widespread　throughout　Southern　Europe　in　non-seismically　designed　industrial　precast　buildings.　First,　geometric　properties　of　industrial　precast　buildings　and　of　the　frictional　beam-to-column　connections,　together　with　reference　values　for　the　friction　coefficient,　are　reviewed.　Then,　earthquake　time　histories　taken　from　the　European　Strong-Motion　sets　and　recordings　of　the　two　major　shocks　of　the　2012　Emilia-Romagna　events　are　presented　and　discussed　showing　the　importance　of　the　vertical　component.　Two　dynamic　models　of　increasing　complexity　are　used　to　ascertain　loss-of-support　conditions　under　seismic　action.　The　first　model　is　an　elastic　one,　representing　a　single　frame　of　the　industrial　buildings.　Results　are　obtained　according　to:　(1)　2D　analyses,　disregarding　the　time　correlation　between　the　response　peaks　along　the　horizontal　and　vertical　directions,　(2)　2D　analyses　taking　into　account　time　correlation,　and　(3)　3D　analyses　to　evaluate　also　directionality　effects.　The　second　model　is　a　2D　non-linear　planar　frame　developed　within　the　OpenSees　framework.　Results　show　that　simplified　(linear)　models　are　a　good　proxy　to　more　refined　(non-linear)　ones.　However,　one　must　resort　to　non-linear　models　if　differential　displacements　between　beam　and　column　are　of　interest.　The　non-linear　numerical　investigations　show　that　friction　coefficient,　horizontal　and　vertical　periods　and　damping,　and　column　reinforcement　ratio　are　the　key　variables　in　estimating　the　loss-of-support　conditions.