The　organic　inorganic　nanohybrids　are　emerging　as　one　of　the　most　attractive　sensing　materials　in　the　area　of　gas　sensors　and　usually　exhibit　some　advanced　properties　because　of　synergetic/complementary　effects　between　organic　molecules　and　inorganic　components.　This　work　demonstrates　a　novel　class　of　organic-inorganic　nanohybrids,　Cu2+-doped　SnO2　nanograin/poly　pyrrole　nanospheres,　for　the　sensitive　room-temperature　H2S　gas　sensing.　Doping　Cu2+　in　SnO2　nanograins　remarkably　enhances　the　surface　potential　barrier　by　tailoring　surface　defects.　After　polymerizing　pyrrole　surrounded　nanograins　in　aqueous　media　to　form　the　organic-inorganic　nanohybrids,　the　resulting　nano-heterojunctions　further　improve　the　sensitivity.　Additionally,　the　nano　hybrids-based　sensor　provides　high　surface　area　and　abounding　reaction　sites　to　accelerate　gas　diffusion　and　adsorption　as　well　as　the　electron　transfer.　Compare　with　pristine　SnO2　nanograins　alone,　the　sensitivity　of　using　the　nanohybrids　increases　7　times　for　the　detection　of　50-ppm　of　H2S.　The　response　and　recovery　rate　can　increase　27　and　22　times　at　room　temperature,　respectively.　Significantly,　this　work　provides　an　attractive　material　for　the　real-time　monitoring　of　H2S,　whereas　the　insights　into　organic-inorganic　composite　interactions　within　the　sensing　mechanism　may　pave　the　way　for　designing　functional　materials　with　tailored　properties.