Magnetic　nanoparticle　(MNP)　hyperthermia　is　a　promising　emerging　therapy　for　cancer　treatment　that　is　minimally　invasive　and　has　been　successfully　used　to　treat　different　types　of　tumors.　The　power　dissipation　of　MNPs,　which　is　one　of　the　most　important　factors　during　a　hyperthermia　treatment,　is　determined　by　the　properties　of　MNPs　and　characteristics　of　the　magnetic　field.　This　paper　proposes　a　method　based　on　the　finite　element　analysis　for　determining　the　value　of　the　power　dissipation　of　particles　(PDP)　that　can　maximize　the　average　temperature　of　the　tumor　during　treatment　and　at　the　same　time　guarantee　that　the　maximum　temperature　is　within　the　therapeutic　range.　The　application　of　the　critical　PDP　value　can　improve　the　effectiveness　of　the　treatment　since　it　increases　the　average　temperature　in　the　tumor　region　while　limiting　the　damage　to　the　healthy　tissue　that　surrounds　it.　After　the　critical　PDP　is　determined　for　a　specific　model,　it　is　shown　how　the　properties　of　the　MNPs　can　be　chosen　to　achieve　the　desired　PDP　value.　The　transient　behavior　of　the　temperature　distribution　for　two　different　models　considering　blood　vessels　is　analyzed　as　a　case　study,　showing　that　the　presence　of　a　blood　vessel　inside　the　tumor　region　can　significantly　decrease　the　uniformity　of　the　temperature　field　and　also　increase　the　treatment　duration　given　its　cooling　effects.　To　present　a　solution　that　does　not　depend　upon　a　good　model　of　the　tumor　region,　an　alternative　method　that　uses　MNPs　with　low　Curie　temperature　is　proposed,　given　the　temperature　self-regulating　properties　of　such　MNPs.　The　results　demonstrate　that　the　uniformity　of　the　temperature　field　can　be　significantly　increased　by　combining　the　optimization　procedure　proposed　in　this　paper　with　the　use　of　low-Curie-temperature　MNPs.　Published　by　AIP　Publishing.