A　hydrothermal　approach　was　used　to　prepare　B-doped　graphene　with　B2O3　as　reductant　and　boron　source.　Results　reveal　that　the　boron　atoms　have　been　successfully　embedded　into　graphene　with　a　high　content　of　a　total　B　species　(2.85　at.%).　Then,　B-doped　graphene　was　exfoliated　further　into　monolayer　nanosheet　by　impregnating　Au@AuPt　core-shell　nanoparticles　(Au@AuPt　NPs)　because　boron　atom　creates　a　net　positive　charge,　which　facilitates　Au@AuPt　NPs　adsorption　to　form　Au@AuPt　NPs/B-doped　graphene　hybrid　nanocatalysts.　After　that,　the　Au@AuPt　NPs/B-doped　hybrid　suspension　was　dropped　on　glassy　carbon　electrode　for　sensing　rutin.　In　this　way,　the　dispersed　carboxyl　units　of　B-doped　graphene　can　form　hydrogen　bonding　with　the　phenolic　hydroxyl　groups　of　rutin,　making　rutin　enrich　easily　on　modified　electrode　surface　to　enhance　the　electrochemical　response.　At　the　same　time,　its　electrochemical　mechanism　on　the　modified　electrode　was　elucidated　using　cyclic　voltammetry.　It　was　found　that　its　electrochemical　behavior　on　modified　electrode　surface　was　a　surface-controlled　quasi-reversible　process,　and　the　charge　transfer　coefficient　(a)　and　electron　transfer　number　(n)　were　0.296　and　2,　respectively.　This　electrochemical　sensor　for　rutin　provided　a　wide　linear　response　range　of　2.00　x　10(-9)-4.00　x　10(-6)　M　with　the　detection　limit　(SIN　=3)　of　2.84　x　10(-10)　M.　The　proposed　method　was　applied　successfully　to　selective　determination　of　rutin　in　Tablets　with　acceptable　recovery　range　(97.23-101.65%).　(C)　2017　Published　by　Elsevier　B.V.