• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

author:

Yang, Chunrong (Yang, Chunrong.) [1] | Wu, Huazhong (Wu, Huazhong.) [2] | Wang, Jianhua (Wang, Jianhua.) [3] (Scholars:王建华)

Indexed by:

EI Scopus SCIE

Abstract:

A multi-layer scaffold that incorporates bioglass, phosphatidylserine and steroidal saponins loaded collagen microparticles was prepared in this study. Combinatorial processing techniques involving porogen leaching protocol and freeze-drying were used. Drug distribution and microstructure could be controlled mainly by the concentrations of drug-loaded collagen microparticles and porogen as well as freezing temperature for different layers of the scaffolds. Morphological observation, measurement of swelling properties, examination of drug release kinetics, and analysis of cell bioactivity showed that the resultant scaffolds had highly interconnected pores, gradient drug distribution and graded porous micro-architecture, similar swelling ratio for different layers, better drug release kinetics in view of lower initial release and slower average release rate compared to the scaffolds with homogeneous structure, as well as approving support of cell ingrowth. This study suggests that the optimized scaffolds have promising potential for applications in bone tissue engineering.

Keyword:

drug distribution microstructure multi-layer scaffold

Community:

  • [ 1 ] [Yang, Chunrong]Fujian Univ Technol, Sch Mat Sci & Engn, Fuzhou, Fujian Province, Peoples R China
  • [ 2 ] [Yang, Chunrong]Fujian Prov Key Lab Adv Mat Proc & Applicat, Fuzhou, Fujian Province, Peoples R China
  • [ 3 ] [Wu, Huazhong]Univ Minjiang, Dept Chem & Chem Engn, Fuzhou, Fujian Province, Peoples R China
  • [ 4 ] [Wang, Jianhua]Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou, Fujian Province, Peoples R China

Reprint 's Address:

  • [Yang, Chunrong]Fujian Univ Technol, Sch Mat Sci & Engn, Fuzhou, Fujian Province, Peoples R China;;[Yang, Chunrong]Fujian Prov Key Lab Adv Mat Proc & Applicat, Fuzhou, Fujian Province, Peoples R China

Show more details

Related Keywords:

Source :

MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS

ISSN: 1516-1439

Year: 2017

Issue: 2

Volume: 20

Page: 349-355

1 . 1 0 3

JCR@2017

1 . 5 0 0

JCR@2023

ESI Discipline: MATERIALS SCIENCE;

ESI HC Threshold:306

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

Online/Total:236/10898603
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1