TiO2　hollow　spheres　modified　with　spatially　separated　Ag　species　and　RuO2　cocatalysts　have　been　prepared　via　an　alkoxide　hydrolysis-precipitation　method　and　a　facile　impregnation　method.　High-resolution　transmission　electron　microscopy　studies　indicate　that　Ag　species　and　RuO2　co-located　on　the　inner　and　outer　surface　of　TiO2　hollow　spheres,　respectively.　The　resultant　catalysts　show　significantly　enhanced　activity　in　photocatalytic　hydrogen　production　under　simulated　sunlight　attributed　to　spatially　separated　Ag　species　and　RuO2　cocatalysts　on　TiO2　hollow　spheres,　which　results　in　the　efficient　separation　and　transportation　of　photogenerated　charge　carriers.