In　this　work,　the　electrochemical　catalytic　properties　of　the　topological　insulator　bismuth　selenide　(Bi2Se3)　were　first　studied.　In　the　presence　of　Bi2Se3　the　reduction　current　of　dissolved　O-2　could　be　significantly　enhanced.　The　electron　transfer　resistivity　(Rct)　was　greatly　reduced　at　the　Bi2Se3　PVP　modified　electrode　as　evidenced　by　the　electrochemical　impedance　spectrometry,　implying　that　the　topological　insulator　Bi2Se3　could　facilitate　the　electron　transfer　at　the　interface　due　to　the　excellent　surface　conductivity.　Based　on　the　high　electrochemical　catalytic　activity　for　the　reduction　of　dissolved　O-2,　the　Bi2Se3　PVP　modified　electrode　was　used　to　detect　glucose　with　the　modification　of　glucose　oxidase,　and　applied　for　the　detection　of　glucose　in　human　blood　serum.　(C)　2013　Elsevier　S.V.　All　rights　reserved.