The　main　objective　of　this　paper　is　to　investigate　the　influence　of　Pile-Soil-Structure　Interaction　(PSSI)　on　pounding　responses　of　adjacent　buildings　earthquakes.　Firstly,　based　on　Penzien　PSSI　model　and　the　contact　element　of　Hertz-damp,　the　analytical　model　for　pounding　of　adjacent　buildings　considering　the　influence　of　PSSI　is　developed.　The　motion　equations　of　pounding　are　derived.　Secondly,　the　numerical　investigation　for　the　pounding　of　two　adjacent　frame　structures　with　pile-foundation　is　conducted　and　the　influence　of　PSSI　on　pounding　of　adjacent　buildings　is　studied.　Finally,　paramterical　studies　about　the　influences　of　soil　and　structural　property　on　the　response　of　pounding　are　examined.　The　results　show　that　the　PSSI　has　an　obvious　influence　on　pounding　of　adjacent　structures　with　pile　foundation.　The　property　of　soil　and　structures,　such　as　shear-wave　velocity　of　soil　and　stiffness　of　pile,　play　significant　roles　on　the　pounding　of　adjacent　buildings.