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Field amplified sample stacking (FASS) was combined with a simple, rapid, sensitive CE-ESI-MS method to achieve the on-line enrichment and simultaneous determination of Clenbuterol (CLE), Salbutamol (SAL), Terbutaline (TER) and Formoterol (FOR). Samples were diluted in deionized water, and electrokinetic injection (10 kV x 50 s) was employed to carry out FASS. With FASS, the four beta(2)-agonists had simultaneously baseline enhancement as much as 319, 332, 297 and 115 fold, respectively. Consequently, satisfactory LODs (S/N=3) of 0.08, 0.1, 0.1 and 0.5 ng/mL for CLE, SAL, TER and FOR were obtained. The separation of the four analytes was performed at 22 kV in ammonium acetate/ammonia (20 mmol/L, pH 9.0), using 7.5 mmol/L acetic acid in isopropanol/water 50/50% (v/v) as sheath liquid. In addition, an excellent linear response was obtained with RSD less than 1.3% for migration times and less than 6.7% for peak areas (n=5). The recoveries of spiked urine samples were in the range of 82.7-101% with RSD lower than 9.8%. The proposed method has been applied to analyze human urine samples successfully. (C) 2012 Elsevier B.V. All rights reserved.
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TALANTA
ISSN: 0039-9140
Year: 2013
Volume: 104
Page: 97-102
3 . 5 1 1
JCR@2013
5 . 6 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
JCR Journal Grade:1
CAS Journal Grade:2
Cited Count:
WoS CC Cited Count: 27
SCOPUS Cited Count: 25
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 2