A　facile　polyhedral　oligomeric　silsesquioxane　(POSS)-based　hybrid　monolith　with　multiple　mechanisms　was　developed　by　an　in　situ　polymerization.　High　mechanical　stability　and　good　separation　capabilities　to　polar　and　hydrophobic　analytes　were　successfully　achieved.　An　ideal　versatile　organic-silica　hybrid　monolith　was　presented　for　easy　access　to　the　efficient　separation　of　various　analytes.