In　this　paper,　a　reactive　distillation　(RD)　column　was　applied　for　synthesis　n-butyl　acetate　from　n-butanol　and　acetic　acid.　The　Langmuir-Hinshelwood-Hougen-Watson　(LHEW)　kinetic　model　and　an　equilibrium　stage　model　for　separation　were　employed　to　study　the　RD　process.　The　results　obtained　from　the　equilibrium　stage　model　agreed　well　with　the　experiments.　The　effects　of　operating　variables　on　the　n-butanol　conversion　and　n-butyl　acetate　purity　were　further　investigated.　The　optimal　column　configuration　for　the　production　of　n-butyl　acetate　was　designed　with　5　rectifying　stages,　8　reaction　stages　and　13　stripping　stages　by　the　simulation　study.　According　to　the　simulation　results,　n-butanol　conversion　and　n-butyl　acetate　purity　all　reached　greater　than　96%.