Uric　acid　(UA)　deposition　in　human　body　is　very　harmful,　since　it　may　induce　gout.　Therefore,　it　would　be　of　great　significance　to　catalyze　the　degradation　of　UA　in　human　body.　Herein,　platinum　nanoparticles　(PtNPs)　were　found　to　be　an　effective　mimic　of　uricase　in　the　oxidation　of　UA.　PtNPs　could　lower　the　activation　energy　of　UA　oxidation　(i.e.,　from　139.49　kJ　mol(-1)　to　61.73　kJ　mol(-1)),　and　thus　increase　the　reaction　rate　constant　dramatically　(e.　g.,　by　the　catalysis　of　2.63　mg　L-1　PtNPs,　the　reaction　rate　constant　of　UA　degradation　at　37　degrees　C　was　5.85　x　10(-4)　s(-1),　which　was　almost　29000　times　higher　than　that　of　without　PtNPs　(2.02　x　10(-8)　s(-1))).　Effects　of　degradation　conditions,　such　as　the　concentration　and　size　of　PtNPs,　concentration　of　dissolved　oxygen　and　pH　value　of　the　solution　on　the　catalytic　degradation　of　UA　have　been　studied.　Furthermore,　products　of　UA　degradation　were　analyzed　by　GC-MS　spectroscopy　and　FT-IR　spectrometry.　On　this　basis,　a　detailed　mechanism　was　finally　proposed　for　the　PtNPs-catalyzed　UA　degradation.