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Abstract：
The di-sulfonated di-phthalimidomethyl phthalocyanine zinc(ZnPcS2P2) was an amphiphilic photosensitizer for photodynamic therapy of cancer. According to fluorescence analytical method, extracting efficiencies of 2.0% SDS(Wt%), 1.5% Triton X-100 (phi) and DMF for ZnPcS2P2 in K562 cells were compared. The results showed that 1.5% Triton X-100 was the most efficient reagent for the first time extracting. Using 1.5% Triton X-100 as extracting reagent, the kinetic curves of cellular uptake of ZnPcS2P2 as well as LDL-ZnPc2P2 complex by K562 cells were determined. Compared with ZnPcS2P2, the maximum cellular uptake of LDL-ZnPcS2P2 by K562 was doubled, which indicated that LDL was an effective targeting delivery vehicle for ZnPcS2P2.
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SPECTROSCOPY AND SPECTRAL ANALYSIS
ISSN： 1000-0593
CN： 11-2200/O4
Year： 2004
Issue： 11
Volume： 24
Page： 1415-1418
0 . 3 5
JCR@2004
0 . 7 0 0
JCR@2023
ESI Discipline： CHEMISTRY;
JCR Journal Grade：4
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SCOPUS Cited Count：
ESI Highly Cited Papers on the List： 0 Unfold All
WanFang Cited Count：
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30 Days PV： 2
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