The　defect　of　digital　PIP　controller　is　that　by　which　time-delay　system　can　not　be　effectively　controlled,　also　the　uncertain　interference　can　not　be　effectively　eliminated.　In　this　paper,　a　class　of　digital　PIP　controller　based　on　Smith　predictive　control　is　presented,　the　resulted　digital　PIP　controller　is　realized　by　single　neuron.　Simulation　research　of　this　resulted　neuron　digital　PIP　controller　used　in　paper-making　machine　is　done　with　MATLAB　soft.　The　simulation　results　show　that　with　this　resulted　neuron　digital　PIP　controller　the　large　time-delay　system　can　be　effectively　controlled,　the　characteristics　of　robustness　and　anti-interference　also　the　dynamic　characteristics　can　be　effectively　improved.