With　the　complication　of　the　road　network,　the　phenomenon　of　traffic　accidents　caused　by　the　overloaded　information　of　the　guide　signs　present　serious　problems.　To　comprehensively　determine　the　reasonable　number　of　place　names　for　guide　signs　in　freeway　interchange　areas　and　propose　corresponding　suggestions　to　improve　the　setting　of　freeway　guide　signs,　we　studied　the　setting　of　guide　signs　on　the　driver＇s　response　efficiency　based　on　the　data　envelopment　analysis　(DEA)　method,　selected　representative　indicators　reflecting　the　driver＇s　cognitive　response　level　on　guide　signs,　and　constructed　a　macro　model　for　the　study　of　the　number　of　place　names　of　the　freeway　guide　signs.　We　used　the　eye　tracker　and　electroencephalogram　(　EEG)　while　performing　the　driving　simulation　experiments　in　relevant　scenes　and　obtained　eye　movement　parameters,　EEG　brain　wave　data,　and　driving　behavior　of　the　subjects　with　different　six　scenes.　Using　the　model　for　data　analysis,　the　average　efficiencies　of　the　driver＇s　cognitive　response　to　the　guide　signs　in　six　scenes　(divided　by　the　number　of　4,5,6,7,8,and　9　place　names)　were　observed　to　be　0.　983,0.　956,0.　902,0.　796,0.　699,and　0.　617,　respectively.　Then,　according　to　the　different　indicator　sets,　we　performed　the　indicator　sensitivity　analysis　to　obtain　the　comprehensive　efficiency　index　of　the　drivers　in　the　six　scenarios.　The　results　reveal　that　as　the　number　of　place　names　increases,　the　average　efficiency　of　the　driver＇s　cognitive　response　to　guide　signs　exhibits　a　downward　trend.　When　the　amount　of　information　exceeds　the　drivers＇　cognitive　threshold,　the　system＇s　overall　efficiency　value　decreases　rapidly.　The　drivers　have　different　level　of　cognitive　response　efficiency　in　different　place　names　scenarios,　leading　to　target　efforts　to　improve　the　response　efficiency　by　modifying　the　layout　design　on　the　guide　signs.　From　the　perspective　of　a　driver＇s　cognitive　response,　the　results　show　that　the　threshold　of　place　names　of　freeway　guidance　signs　is　suggested　at　6.　This　study　used　the　DEA　method　to　construct　a　comprehensive　index　system　to　analyze　the　number　of　place　names　of　the　guide　signs　from　the　perspective　of　a　driver＇s　cognitive　response　to　the　guiding　signs,　and　provided　a　practical　reference　for　the　layout　of　the　guide　signs　for　freeway　interchange　areas　in　China.　©　2020,　Editorial　Department　of　China　Journal　of　Highway　and　Transport.　All　right　reserved.