Enzymatic　reactive　distillation　which　combines　the　enzyme-catalyzed　reaction　with　distillation　process　can　be　used　to　break　the　limitation　of　reaction　equilibrium　and　improve　the　conversion　and　selectivity　effectively.　It　is　a　new　process　intensification　technology.　In　this　paper,　the　progress　of　enzymatic　reactive　distillation　coupling　technology　is　reviewed　from　the　enzyme　catalyst　and　its　catalytic　reaction　mechanism,　the　packing　method　of　enzyme　catalyst,　the　coupling　mode　of　enzyme　reaction　and　distillation　process　and　several　application　cases.　It　shows　that　current　development　of　enzyme　reactive　distillation　coupling　technique　is　not　mature.　The　enzyme-catalyzed　reactive　distillation　is　quite　different　with　the　reactive　distillation　catalyzed　by　chemical　catalyst.　And　the　influences　of　parameters　such　as　reaction　temperature,　substrate　concentration　on　enzyme　catalytic　activity　should　be　considered.　In　the　future,　the　strengthening　research　can　be　carried　out　from　the　research　system,　enzyme　immobilization　technology,　enzyme　catalyst　loading　mode,　enzyme　reactive　distillation　theory　research,　enzyme　reactive　distillation　coupling　process　development　and　so　on.　©　All　Right　Reserved.