Aiming　at　the　rational　design　and　controllable　preparation　of　highly　selective　fluid　catalytic　cracking　(FCC)　naphtha　hydrodesulfurization　(HDS)　catalyst,　a　two-dimensional　lattice　Boltzmann　method　with　multi-relaxation-time　collision　operator　was　developed　to　simulate　the　intraparticle　diffusivities　in　alumina　supports.　The　simulation　results　showed　that,　in　a　series　of　virtual　alumina　supports　with　the　identical　mesoporous　structure　but　different　macroporous　structures,　which　were　constructed　via　the　random　generation　of　macro-mesopores,　the　intraparticle　diffusivity　increases　sharply　with　the　increasing　macropore　volume　and　diameter,　with　the　one　having　macropore　volume　0.55　cm3/g　and　macropore　diameter　500　nm　simultaneously　guaranteeing　both　satisfactory　intraparticle　diffusion　performance　and　suitable　crushing　strength.　Based　on　the　simulation　results,　five　γ-Al2O3　supports　with　the　identical　mesoporous　structure　but　different　macroporous　structures　were　synthesized　from　the　same　pseudo-boehmite　precursor　by　using　sodium　polyacrylate　and　different　amounts　of　water　during　shaping,　from　which　five　CoMo/γ-Al2O3　catalysts　were　prepared.　The　HDS　assessment　results　obtained　using　a　real　FCC　naphtha　showed　that,　compared　with　the　reference　catalyst　prepared　from　an　alumina　without　macropores,　the　catalysts　prepared　from　the　aluminas　with　different　macroporous　structures　displayed　higher　HDS　selectivity　due　to　the　enhanced　diffusion　in　macropores.　The　systematic　characterization　results　demonstrated　that　the　enhanced　HDS　activities　and　selectivities　of　the　macroporous　alumina　supported　catalysts　are　mainly　attributed　to　the　enhanced　diffusion　in　macropores.　©　2020　Elsevier　B.V.