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author：

Wu, Lingling (Wu, Lingling.) [1] | Ding, Hongming (Ding, Hongming.) [2] | Qu, Xin (Qu, Xin.) [3] | Shi, Xianai (Shi, Xianai.) [4] | Yang, Jianmin (Yang, Jianmin.) [5] | Huang, Mengjiao (Huang, Mengjiao.) [6] | Zhang, Jialu (Zhang, Jialu.) [7] | Zhang, Huimin (Zhang, Huimin.) [8] | Song, Jia (Song, Jia.) [9] | Zhu, Lin (Zhu, Lin.) [10] | Song, Yanling (Song, Yanling.) [11] | Ma, Yuqiang (Ma, Yuqiang.) [12] | Yang, Chaoyong (Yang, Chaoyong.) [13]

Indexed by：

EI

Abstract：

The　ubiquitous　biomembrane　interface,　with　its　dynamic　lateral　fluidity,　allows　membrane-bound　components　to　rearrange　and　localize　for　high-affinity　multivalent　ligand-receptor　interactions　in　diverse　life　activities.　Inspired　by　this,　we　herein　engineered　a　fluidic　multivalent　nanointerface　by　decorating　a　microfluidic　chip　with　aptamer-functionalized　leukocyte　membrane　nanovesicles　for　high-performance　isolation　of　circulating　tumor　cells　(CTCs).　This　fluidic　biomimetic　nanointerface　with　active　recruitment-binding　afforded　significant　affinity　enhancement　by　4　orders　of　magnitude,　exhibiting　7-fold　higher　capture　efficiency　compared　to　a　monovalent　aptamer　functionalized-chip　in　blood.　Meanwhile,　this　soft　nanointerface　inherited　the　biological　benefits　of　a　natural　biomembrane,　minimizing　background　blood　cell　adsorption　and　maintaining　excellent　CTC　viability　(97.6%).　Using　the　chip,　CTCs　were　successfully　detected　in　all　cancer　patient　samples　tested　(17/17),　suggesting　the　high　potential　of　this　fluidity-enhanced　multivalent　binding　strategy　in　clinical　applications.　We　expect　this　bioengineered　interface　strategy　will　lead　to　the　design　of　innovative　biomimetic　platforms　in　the　biomedical　field　by　leveraging　natural　cell-cell　interaction　with　a　natural　biomaterial.　©　2020　American　Chemical　Society.

Keyword：

Biochips Biological membranes Biomimetics Blood Efficiency Fluidity Tumors

Community：

  • [ 1 ] [Wu, Lingling]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200127, China
  • [ 2 ] [Ding, Hongming]Center for Soft Condensed Matter Physics and Interdisciplinary Research, School of Physical Science and Technology, Soochow University, Suzhou; 215006, China
  • [ 3 ] [Qu, Xin]College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, Fujian; 350108, China
  • [ 4 ] [Shi, Xianai]College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, Fujian; 350108, China
  • [ 5 ] [Yang, Jianmin]College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou, Fujian; 350108, China
  • [ 6 ] [Huang, Mengjiao]MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 7 ] [Zhang, Jialu]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200127, China
  • [ 8 ] [Zhang, Huimin]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200127, China
  • [ 9 ] [Song, Jia]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200127, China
  • [ 10 ] [Zhu, Lin]MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 11 ] [Song, Yanling]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200127, China
  • [ 12 ] [Song, Yanling]MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China
  • [ 13 ] [Ma, Yuqiang]National Laboratory of Solid State Microstructures, Department of Physics, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing; 210093, China
  • [ 14 ] [Yang, Chaoyong]Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, School of Medicine, Shanghai; 200127, China
  • [ 15 ] [Yang, Chaoyong]MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen; 361005, China

Reprint 's Address：

  • [song, yanling]moe key laboratory of spectrochemical analysis and instrumentation, key laboratory for chemical biology of fujian province, state key laboratory of physical chemistry of solid surfaces, department of chemical biology, college of chemistry and chemical engineering, xiamen university, xiamen; 361005, china;;[song, yanling]institute of molecular medicine, renji hospital, school of medicine, shanghai jiao tong university, school of medicine, shanghai; 200127, china

Email：


ylsong@xmu.edu.cn
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Source ：

Journal of the American Chemical Society

ISSN： 0002-7863

Year： 2020

Issue： 10

Volume： 142

Page： 4800-4806

1 5 . 4 1 9

JCR@2020

1 4 . 5 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

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