Silk fibroin/collagen/hyaluronic acid scaffold incorporating pilose antler polypeptides microspheres for cartilage tissue engineering - Details

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Abstract：

A　silk　fibroin/collagen/hyaluronic　acid　(SF/COL/HA)　composite　scaffold　was　prepared　via　admixing,　crosslinking,　and　lyophilizing　processes.　We　studied　its　physicochemical　and　biological　properties,　such　as　water　absorption,　porosity,　weight　loss,　and　biocompatibility.　The　optimal　ratio　of　SF/COL/HA　scaffold　was　3:6.5:0.5.　Then,　the　optimal　ratio　of　scaffold　incorporating　pilose　antler　polypeptides　(PAPs)–PLGA　microspheres　was　prepared,　and　their　compatibility　was　studied.　PAP-SF/COL/HA　scaffold　had　favorable　adhesion　and　proliferation.　A　rabbit　cartilage　defect　model　was　established.　The　repair　effect　of　cartilage　defects　was　observed　and　evaluated　among　PAP-SF/COL/HA,　SF/COL/HA,　and　sham　operation　groups.　The　defects　were　almost　completely　repaired　after　13　weeks　in　the　PAP-SF/COL/HA　group,　thereby　indicating　that　the　PAP-SF/COL/HA　composite　had　a　favorable　effect　on　articular　cartilage　repair.　©　2018　Elsevier　B.V.

Keyword：

Biocompatibility Cartilage Collagen Defects Hyaluronic acid Microspheres Physicochemical properties Repair Scaffolds (biology) Water absorption

Community：

[ 1 ] [Wang, Jianhua]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou; 350001, China
[ 2 ] [Wang, Jianhua]Bote Biotech. Co., Ltd., Fujian; 350014, China
[ 3 ] [Sun, Xiaomin]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou; 350001, China
[ 4 ] [Zhang, Zhihua]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou; 350001, China
[ 5 ] [Wang, Yingying]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou; 350001, China
[ 6 ] [Huang, Chenguang]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou; 350001, China
[ 7 ] [Yang, Chunrong]Department of Materials Science and Engineering, Fujian University of Technology, Fuzhou; 350118, China
[ 8 ] [Liu, Lingrong]Key Laboratory of Biomedical Materials of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin; 300192, China
[ 9 ] [Zhang, Qiqing]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou; 350001, China

Reprint 's Address：

[wang, jianhua]institute of biomedical and pharmaceutical technology, fuzhou university, fuzhou; 350001, china;;[wang, jianhua]bote biotech. co., ltd., fujian; 350014, china

Email：

ibptwjh@fzu.edu.cn

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Source ：

Materials Science and Engineering C

ISSN： 0928-4931

Year： 2019

Volume： 94

Page： 35-44

5 . 8 8

JCR@2019

8 . 1 0 0

JCR@2023

JCR Journal Grade：1

CAS Journal Grade：2

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WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 1

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