Diesel　production　with　low/no　sulfur　content　is　a　major　trend　in　world-wide　development　of　clean　fuels.　Among　many　alternative　technologies,　hydrogenation　desulfurization　(HDS)　is　most　effective　to　produce　clean　diesel　at　industrial　scale,　which　development　of　highly　active　catalysts　is　the　key.　In　this　study,　a　series　of　Mo/Al2O3-MgO　catalysts　were　prepared　by　metal　oxide　composites　of　MgAl-hydrotalcite　and　alumina　as　carriers　with　incipient-wetness　impregnation　method.　Their　catalytic　performance　was　evaluated　on　dibenzothiophene　(DBT)　solution　in　n-heptane　as　raw　material　in　a　fixed-bed　reactor.　The　results　showed　that　Mg/Al　molar　ratio,　calcination　temperature,　and　additive　amount　all　affected　acidity,　reduction　and　sulfidation　of　the　catalysts　and　stacking　degree　of　MoS2　crystallites.　When　Mg/Al　molar　ratio　was　3,　calcination　temperature　was　800,　and　hydrotalcite　was　10%　(mass),　the　obtained　catalyst　has　the　highest　HDS　activity　with　up　to　96.2%　desulfurization　rate.　Appropriate　catalyst　acidity　and　suitable　interaction　between　active　component　and　carrier　make　it　easier　to　sulfide　the　active　component,　which　is　beneficial　to　improve　stacking　degree　of　MoS2　crystallites　and　enhance　catalytic　performance.　©　All　Right　Reserved.