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author：

Chen, Xiufen (Chen, Xiufen.) [1] | Chen, Jianzhong (Chen, Jianzhong.) [2] | Li, Bowen (Li, Bowen.) [3] | Yang, Xiang (Yang, Xiang.) [4] | Zeng, Rongjie (Zeng, Rongjie.) [5] | Liu, Yajun (Liu, Yajun.) [6] | Li, Tao (Li, Tao.) [7] | Ho, Rodney J.Y. (Ho, Rodney J.Y..) [8] | Shao, Jingwei (Shao, Jingwei.) [9]

Indexed by：

EI

Abstract：

Poly　(D,L-lactide-co-glycolide)-poly　(ethylene　glycol)-poly　(D,L-lactide-co-glycolide)　triblock　copolymers　(PLGA-PEG-PLGA)　has　been　proven　to　be　desirable　for　anti-cancer　drug　delivery　by　intravenous　administration.　But　till　now　there　is　no　report　of　developing　this　micelle　as　a　sustained　oral　formulation　for　cancer　therapy.　3β-acetoxy-urs-12-en-28-oic　acid　hexamethylenediamine　(US597),　a　derivative　of　natural　product　ursolic　acid　has　been　developed　as　a　novel　cancer　metastasis　chemopreventive　agent　by　us.　Herein,　we　developed　a　new　oral　dosage　formulation　of　PLGA-PEG-PLGA　tri-block　micelles　loaded　with　US597　(US597@micelles).　US597@micelles　was　prepared　by　a　double　emulsion　solvent　evaporation　method,　and　characterized　in　regards　to　mean　diameter　( 　©　2016　Elsevier　Inc.

Keyword：

Biochemistry Cell death Cell proliferation Controlled drug delivery Diseases Emulsification Micelles Oncology Pharmacokinetics Polyethylene glycols Polyethylene oxides Targeted drug delivery

Community：

  • [ 1 ] [Chen, Xiufen]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 2 ] [Chen, Jianzhong]School of Renewable Natural Resources, LSU Agricultural Center, Louisiana State University, Baton Rouge; 70803, United States
  • [ 3 ] [Li, Bowen]Department of Bioengineering and Pharmaceutics, University of Washington, Seattle; WA; 98195, United States
  • [ 4 ] [Yang, Xiang]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 5 ] [Zeng, Rongjie]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 6 ] [Liu, Yajun]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 7 ] [Li, Tao]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350002, China
  • [ 8 ] [Ho, Rodney J.Y.]Department of Bioengineering and Pharmaceutics, University of Washington, Seattle; WA; 98195, United States
  • [ 9 ] [Shao, Jingwei]Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou; 350002, China

Reprint 's Address：

  • [shao, jingwei]cancer metastasis alert and prevention center, pharmaceutical photocatalysis of state key laboratory of photocatalysis on energy and environment, college of chemistry, fuzhou university, fuzhou; 350002, china

Email：


shaojingwei@fzu.edu.cn
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Source ：

Journal of Colloid and Interface Science

ISSN： 0021-9797

Year： 2017

Volume： 490

Page： 542-552

5 . 0 9 1

JCR@2017

9 . 4 0 0

JCR@2023

ESI HC Threshold：226

JCR Journal Grade：1

CAS Journal Grade：3

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 72

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 3

Affiliated Colleges：

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