Improvement　of　mechanical　and　thermal　properties　is　always　the　goal　of　high-performance　general　plastic　for　engineering　applications.　Herein,　isotactic　polypropylene/glass　fiber/tetrapod-shaped　zinc　oxide　(iPP/GF/T-ZnOw)　composites　are　developed　via　melt-extrusion　on　twin-screw　extruder.　To　improve　the　distribution　of　T-ZnOw　in　iPP　matrix,　T-ZnOw　is　first　modified　by　various　silane　coupling　agents　and　its　structure　is　characterized　by　scanning　electron　microscopy,　Fourier　transform　infrared　spectra,　and　X-ray　diffraction　(XRD).　The　optimized　treatment　condition　is　determined　via　comparison　of　activation　index.　The　introduction　of　GF　and　T-ZnOw　could　improve　the　mechanical　properties　including　tensile　strength,　elastic　modulus,　flexural　strength,　flexural　modulus,　and　impact　strength,　indicating　that　the　surface　modification　and　compatibilizer　could　enhance　the　interfacial　interaction　of　iPP/GF/T-ZnOw　composites.　Moreover,　XRD　and　differential　scanning　calorimentryresults　show　that　T-ZnOw　as　a　novel　β-nucleating　agent　could　induce　the　formation　of　β-crystal　and　the　existence　of　GF　counteracts　the　formation　of　β-crystal　induced　by　T-ZnOw.　©　2016　Wiley　Periodicals,　Inc.　J.　Appl.　Polym.　Sci.　2016,　133,　44217.　©　2016　Wiley　Periodicals,　Inc.