The　removal　of　highly　radioactive　and　long-lived　137Cs+　and　90Sr2+　from　solution　is　of　significance　for　radionuclide　remediation.　Herein　we　prepared　a　two-dimensionally　microporous　thiostannate,　namely　(Me2NH2)4/3(Me3NH)2/3Sn3S7·1.25H2O　(FJSM-SnS),　and　systematically　investigated　its　Cs+　and　Sr2+　ion-exchange　performance　in　different　conditions.　The　structural　stabilities　and　variation,　ion-exchange　kinetic　and　isothermal　behavior,　pH-dependent　distribution　coefficients　(Kd),　ion-exchange　in　simulated　groundwater　and　ion-exchange　applied　to　chromatography　have　been　investigated.　The　results　indicated　that　the　maximum　Cs+　and　Sr2+　ion-exchange　capacities　of　FJSM-SnS　were　408.91　mg　g-1　and　65.19　mg　g-1,　respectively.　In　particular,　FJSM-SnS　showed　quick　ion-exchange　ability　and　wide　pH　resistance　(0.7-12.7)　which　make　it　outstanding　among　the　ion-exchangers.　An　ion-exchange　chromatographic　column　was　firstly　studied　for　chalcogenido　ion-exchange　materials,　that　is,　a　column　filled　with　3.0　g　FJSM-SnS　could　remove　96-99%　of　Cs+　ion　and　near　100%　of　Sr2+　ion　at　low　ionic　concentrations　in　900　bed　volumes　solutions.　Furthermore,　the　title　material　could　be　synthesized　on　a　large　scale　by　a　facile,　one-pot　and　economical　solvothermal　method.　The　relatively　low　cost　but　remarkable　ion-exchange　performance　makes　it　promising　for　radionuclide　remediation.　This　journal　is　©　The　Royal　Society　of　Chemistry.