Chitosan　was　selected　as　organic　matrix　to　synthetize　nano　hydroxyapatite　in　situ.　By　the　high　voltage　static　micro　capsule　forming　device,　a　kind　of　novel　composite　microsphere-chitosan/hydroxyapatite　loading　ircaiin　was　prepared,　sustaining　release　drug　for　bone　tissue　recovery.　Results　indicate　that　the　morphology　of　composite　microspheres　are　round,　and　the　particle　size　is　about　200　µm.　Nano　hydroxyapatite　is　formed　in　situ　and　composite　microspheres　provide　a　good　coating　for　ircaiin.　In　conclusion,　the　composite　microspheres　can　promote　osteoblast　proliferation.　©,　2015,　Science　Press.　All　right　reserved.