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author:

Huang, Ying (Huang, Ying.) [1] | Jiang, Xiuyan (Jiang, Xiuyan.) [2] | Wang, Wei (Wang, Wei.) [3] | Duan, Jianping (Duan, Jianping.) [4] | Chen, Guonan (Chen, Guonan.) [5]

Indexed by:

EI

Abstract:

A method of capillary electrophoresis with wall-jet amperometric detection (AD) has been developed for separation and determination of l-tyrosine (Tyr) and its metabolites, such as Tyramine (TA), p-hydroxyphenylpyruvic (pHPP), homogentisic acid (HGA) and some dipeptides containing Tyr, such as Tyr-Gly-Gly (YGG), Tyr-Arg (YR) and Tyr-d-Arg (Y-d-R). A carbon disk electrode was used as the working electrode and the optimal detection potential was 1.00 V (versus Ag/AgCl). At 18 kV of applied voltage, the seven compounds were completely separated within 20 min in 110 × 10-3 mol/L Na2HPO4-NaH2PO4 buffer (pH 7.10) containing 3 × 10-3 mol/L β-cyclodextrin (β-CD). Good linear relationship was obtained for all analytes and the detection limits of seven analytes were in the range of 0.95-4.25 ng/mL. The proposed method has been applied to examine the metabolic process of l-tyrosine in rabbit's urine. © 2006 Elsevier B.V. All rights reserved.

Keyword:

Drug products Electric potential Electrophoresis Metabolites Pharmacokinetics Separation

Community:

  • [ 1 ] [Huang, Ying]The MOE Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China
  • [ 2 ] [Huang, Ying]College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian 350007, China
  • [ 3 ] [Jiang, Xiuyan]The MOE Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China
  • [ 4 ] [Wang, Wei]The MOE Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China
  • [ 5 ] [Duan, Jianping]The MOE Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China
  • [ 6 ] [Chen, Guonan]The MOE Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China

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Source :

Talanta

ISSN: 0039-9140

Year: 2006

Issue: 5

Volume: 70

Page: 1157-1163

2 . 8 1

JCR@2006

5 . 6 0 0

JCR@2023

JCR Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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