• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
成果搜索

author:

Peng, Yiru (Peng, Yiru.) [1] | Lin, Zhipeng (Lin, Zhipeng.) [2] | Huang, Jinling (Huang, Jinling.) [3] | Chen, Naisheng (Chen, Naisheng.) [4]

Indexed by:

EI

Abstract:

An amphiphilic 2,10-di-sulfonato-18,26-di-phthalimidomethyl phthalocyanine zinc di-potassium salt (3) was synthesized by first direct condensation of hydrophilic precursor 4-sulfonic phthalic acid mono-potassium salt (1) with hydrophobic precursor 4-phthalimidomethyl phthalic acid (2). Then the condensed mixture was separated by reverse HPLC method and further purified by a membrane separation method. The composition of the title compound was characterized by elemental analysis, UV, 1H NMR, 13C NMR as well as TG and DTA, and its C4h-structure was identified according to the 1H NMR signal of submethyl protons of the phthalimidomethyl groups in the phthalocyanine ring, polarity and synthetic mechanism. In vivo antitumor activity of the title compound as photosensitizer showed that its inhibitory rate was up to 90.3%. This amphiphilic photosensitizer has a potential application in the photodynamic therapy of cancer. © 2004 Elsevier Ltd. All rights reserved.

Keyword:

Condensation Differential thermal analysis Hydrophilicity Hydrophobicity Molecular structure Nuclear magnetic resonance Photodynamic therapy Photosensitizers Potassium compounds Salts Separation Synthesis (chemical) Thermogravimetric analysis Tumors Zinc compounds

Community:

  • [ 1 ] [Peng, Yiru]College of Chemistry and Materials, Fujian Normal University, Fuzhou 350007, China
  • [ 2 ] [Lin, Zhipeng]Department of Chemistry, Fuzhou University, Fuzhou 350002, China
  • [ 3 ] [Huang, Jinling]Department of Chemistry, Fuzhou University, Fuzhou 350002, China
  • [ 4 ] [Chen, Naisheng]Department of Chemistry, Fuzhou University, Fuzhou 350002, China

Reprint 's Address:

Show more details

Related Keywords:

Source :

Dyes and Pigments

ISSN: 0143-7208

Year: 2005

Issue: 2

Volume: 67

Page: 145-151

1 . 6 9 4

JCR@2005

4 . 1 0 0

JCR@2023

JCR Journal Grade:1

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 14

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

Affiliated Colleges:

Online/Total:178/10012260
Address:FZU Library(No.2 Xuyuan Road, Fuzhou, Fujian, PRC Post Code:350116) Contact Us:0591-22865326
Copyright:FZU Library Technical Support:Beijing Aegean Software Co., Ltd. 闽ICP备05005463号-1