The　intensive　network　technology　that　is　one　of　the　key　technologies　of　5G　is　the　main　means　to　solve　the　explosive　growth　of　data　traffic　demands　in　the　future.　However,　with　the　implementation　of　network-inte-nsive　deployments,　serious　interference　problems　are　generated.　The　software-defined　network　(SDN)　allows　the　separation　of　the　control　plane　from　forward　plane,　which　provides　the　flexibility　of　dynamic　network　programming.　Combining　SDN　with　5G　is　an　effective　method　to　copy　with　the　interference　management.　This　paper　proposes　an　SDN-based　mobile　wireless　network　architecture　to　solve　the　problem　of　interference　coordination　in　mobile　wireless　networks.　Through　the　advantages　of　the　SDN　controller,　the　underlying　wireless　network　topology　information　is　centralized　to　the　control　layer　that　is　running　the　optimization　algorithm　of　resource　allocation,　which　solves　the　problem　of　interference　coordination.　We　introduces　an　Integer　Programming　to　sovle　the　problem　of　formulation.　A　Tabu　heuristic　algorithm　is　used　to　solve　the　problem　of　interference　coordination.　The　experimental　results　show　that　compared　with　the　algorithm　of　non　interference　coordination,　the　proposed　algorithm　evidently　reduces　the　interference　value　of　the　whole　network.　©　ICST　Institute　for　Computer　Sciences,　Social　Informatics　and　Telecommunications　Engineering　2019.