This　paper　introduces　the　hardware　implementation　architecture　of　real-time　ECG　R-wave　detection　with　wavelet　transform　algorithm.　According　to　the　principle　of　mutation　point　detection　based　on　wavelet　transform,　we　determine　the　position　of　R-wave　by　the　modulus　maximum　of　the　wavelet　coefficients.　Moreover,　the　proposed　hardware　implementation　architecture　is　optimized　based　on　the　characteristics　of　the　wavelet　transform　algorithm.　The　clinical　data　of　MIT-BIH　arrhythmia　database　is　used　to　verify　the　proposed　algorithm　and　hardware　implementation　architecture.　©　2018　Copyright　is　held　by　the　owner/author(s).　Publication　rights　licensed　to　ACM.