As　a　new　type　structure,　the　dynamic　behavior　of　the　irregular　concrete　filled　steel　tube　arch　bridge　under　moving　vehicles　was　rarely　studied.　In　this　paper,　taking　the　bridge　crossing　Yitong　river　in　Changchun　of　China　as　an　example,　the　dynamic　response　of　the　bridge　is　investigated　by　the　self-compiling　vehicle-bridge　coupled　vibration　analysis　program.　The　surface　roughness　and　vehicle　speed　are　considered　in　the　analysis.　The　results　show　that　impact　factors　of　the　bridge　increase　as　surface　roughness　deteriorated;　the　impact　factor　varies　obviously　for　the　different　component;　the　tension　impact　factor　of　the　short　suspender　is　larger　than　that　of　long　ones;　damping　ratio　of　structure　has　little　effect　on　the　impact　factors.　The　research　conclusions　can　be　referred　in　the　design　and　assessment　for　the　similar　bridges.　©　(2011)　Trans　Tech　Publications,　Switzerland.